515 research outputs found
158: Relapse of Acute Myeloid Leukmia after Allogeneic Stem-Cell Transplantation (SCT) with Myeloablative Conditioning is Associated with Longer Survival than Relapse after Reduced-Intensity Conditioning (RIC)
Electromigration-Induced Flow of Islands and Voids on the Cu(001) Surface
Electromigration-induced flow of islands and voids on the Cu(001) surface is
studied at the atomic scale. The basic drift mechanisms are identified using a
complete set of energy barriers for adatom hopping on the Cu(001) surface,
combined with kinetic Monte Carlo simulations. The energy barriers are
calculated by the embedded atom method, and parameterized using a simple model.
The dependence of the flow on the temperature, the size of the clusters, and
the strength of the applied field is obtained. For both islands and voids it is
found that edge diffusion is the dominant mass-transport mechanism. The rate
limiting steps are identified. For both islands and voids they involve
detachment of atoms from corners into the adjacent edge. The energy barriers
for these moves are found to be in good agreement with the activation energy
for island/void drift obtained from Arrhenius analysis of the simulation
results. The relevance of the results to other FCC(001) metal surfaces and
their experimental implications are discussed.Comment: 9 pages, 13 ps figure
Electromigration-Induced Propagation of Nonlinear Surface Waves
Due to the effects of surface electromigration, waves can propagate over the
free surface of a current-carrying metallic or semiconducting film of thickness
h_0. In this paper, waves of finite amplitude, and slow modulations of these
waves, are studied. Periodic wave trains of finite amplitude are found, as well
as their dispersion relation. If the film material is isotropic, a wave train
with wavelength lambda is unstable if lambda/h_0 < 3.9027..., and is otherwise
marginally stable. The equation of motion for slow modulations of a finite
amplitude, periodic wave train is shown to be the nonlinear Schrodinger
equation. As a result, envelope solitons can travel over the film's surface.Comment: 13 pages, 2 figures. To appear in Phys. Rev.
A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases
© 2015 Macmillan Publishers Limited. All rights reserved. Fast and reliable DNA sequencing is a long-standing target in biomedical research. Recent advances in graphene-based electrical sensors have demonstrated their unprecedented sensitivity to adsorbed molecules, which holds great promise for label-free DNA sequencing technology. To date, the proposed sequencing approaches rely on the ability of graphene electric devices to probe molecular-specific interactions with a graphene surface. Here we experimentally demonstrate the use of graphene field-effect transistors (GFETs) as probes of the presence of a layer of individual DNA nucleobases adsorbed on the graphene surface. We show that GFETs are able to measure distinct coverage-dependent conductance signatures upon adsorption of the four different DNA nucleobases; a result that can be attributed to the formation of an interface dipole field. Comparison between experimental GFET results and synchrotron-based material analysis allowed prediction of the ultimate device sensitivity, and assessment of the feasibility of single nucleobase sensing with graphene
Allogeneic Hematopoietic Stem Cell Transplantation With Reduced-Intensity Conditioning In Patients With Refractory And Relapsing Multiple Myeloma: Long-Term Follow-Up
Necessity of Superposition of Macroscopically Distinct States for Quantum Computational Speedup
For quantum computation, we investigate the conjecture that the superposition
of macroscopically distinct states is necessary for a large quantum speedup.
Although this conjecture was supported for a circuit-based quantum computer
performing Shor's factoring algorithm [A. Ukena and A. Shimizu, Phys. Rev. A69
(2004) 022301], it needs to be generalized for it to be applicable to a large
class of algorithms and/or other models such as measurement-based quantum
computers. To treat such general cases, we first generalize the indices for the
superposition of macroscopically distinct states. We then generalize the
conjecture, using the generalized indices, in such a way that it is
unambiguously applicable to general models if a quantum algorithm achieves
exponential speedup. On the basis of this generalized conjecture, we further
extend the conjecture to Grover's quantum search algorithm, whose speedup is
large but quadratic. It is shown that this extended conjecture is also correct.
Since Grover's algorithm is a representative algorithm for unstructured
problems, the present result further supports the conjecture.Comment: 18 pages, 5 figures. Fixed typos throughout the manuscript. This
version has been publishe
A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer's disease
1,1′-(4,4′-Bipiperidine-1,1′-diÂyl)bisÂ(2,2,2-trifluoroÂethanone)
The title compound, C14H18F6N2O2, has a central center of symmetry with both piperidine rings occurring in regular chair conformations. Even though the structure is fairly compact with no sizable voids, the shortest H⋯O distance is as long as 2.58 Å
Wheat (Triticum aestivum L.) [gamma]-Gliadin Accumulates in Dense Protein Bodies within the Endoplasmic Reticulum of Yeast
- …