1,079 research outputs found
A semismooth newton method for the nearest Euclidean distance matrix problem
The Nearest Euclidean distance matrix problem (NEDM) is a fundamentalcomputational problem in applications such asmultidimensional scaling and molecularconformation from nuclear magnetic resonance data in computational chemistry.Especially in the latter application, the problem is often large scale with the number ofatoms ranging from a few hundreds to a few thousands.In this paper, we introduce asemismooth Newton method that solves the dual problem of (NEDM). We prove that themethod is quadratically convergent.We then present an application of the Newton method to NEDM with -weights.We demonstrate the superior performance of the Newton method over existing methodsincluding the latest quadratic semi-definite programming solver.This research also opens a new avenue towards efficient solution methods for the molecularembedding problem
Assessment of the kidneys: magnetic resonance angiography, perfusion and diffusion
Renal magnetic resonance (MR) imaging has undergone major improvements in the past several years. This review focuses on the technical basics and clinical applications of MR angiography (MRA) with the goal of enabling readers to acquire high-resolution, high quality renal artery MRA. The current role of contrast agents and their safe use in patients with renal impairment is discussed. In addition, an overview of promising techniques on the horizon for renal MR is provided. The clinical value and specific applications of renal MR are critically discussed
On the Schoenberg Transformations in Data Analysis: Theory and Illustrations
The class of Schoenberg transformations, embedding Euclidean distances into
higher dimensional Euclidean spaces, is presented, and derived from theorems on
positive definite and conditionally negative definite matrices. Original
results on the arc lengths, angles and curvature of the transformations are
proposed, and visualized on artificial data sets by classical multidimensional
scaling. A simple distance-based discriminant algorithm illustrates the theory,
intimately connected to the Gaussian kernels of Machine Learning
Interplay of size and Landau quantizations in the de Haas-van Alphen oscillations of metallic nanowires
We examine the interplay between size quantization and Landau quantization in
the De Haas-Van Alphen oscillations of clean, metallic nanowires in a
longitudinal magnetic field for `hard' boundary conditions, i.e. those of an
infinite round well, as opposed to the `soft' parabolically confined boundary
conditions previously treated in Alexandrov and Kabanov (Phys. Rev. Lett. {\bf
95}, 076601 (2005) (AK)). We find that there exist {\em two} fundamental
frequencies as opposed to the one found in bulk systems and the three
frequencies found by AK with soft boundary counditions. In addition, we find
that the additional `magic resonances' of AK may be also observed in the
infinite well case, though they are now damped. We also compare the numerically
generated energy spectrum of the infinite well potential with that of our
analytic approximation, and compare calculations of the oscillatory portions of
the thermodynamic quantities for both models.Comment: Title changed, paper streamlined on suggestion of referrees, typos
corrected, numerical error in figs 2 and 3 corrected and final result
simplified -- two not three frequencies (as in the previous version) are
observed. Abstract altered accordingly. Submitted to Physical Review
Geometrical Insights for Implicit Generative Modeling
Learning algorithms for implicit generative models can optimize a variety of
criteria that measure how the data distribution differs from the implicit model
distribution, including the Wasserstein distance, the Energy distance, and the
Maximum Mean Discrepancy criterion. A careful look at the geometries induced by
these distances on the space of probability measures reveals interesting
differences. In particular, we can establish surprising approximate global
convergence guarantees for the -Wasserstein distance,even when the
parametric generator has a nonconvex parametrization.Comment: this version fixes a typo in a definitio
Ginzburg-Landau-Gor'kov Theory of Magnetic oscillations in a type-II 2-dimensional Superconductor
We investigate de Haas-van Alphen (dHvA) oscillations in the mixed state of a
type-II two-dimensional superconductor within a self-consistent Gor'kov
perturbation scheme. Assuming that the order parameter forms a vortex lattice
we can calculate the expansion coefficients exactly to any order. We have
tested the results of the perturbation theory to fourth and eight order against
an exact numerical solution of the corresponding Bogoliubov-de Gennes
equations. The perturbation theory is found to describe the onset of
superconductivity well close to the transition point . Contrary to
earlier calculations by other authors we do not find that the perturbative
scheme predicts any maximum of the dHvA-oscillations below . Instead we
obtain a substantial damping of the magnetic oscillations in the mixed state as
compared to the normal state. We have examined the effect of an oscillatory
chemical potential due to particle conservation and the effect of a finite
Zeeman splitting. Furthermore we have investigated the recently debated issue
of a possibility of a sign change of the fundamental harmonic of the magnetic
oscillations. Our theory is compared with experiment and we have found good
agreement.Comment: 39 pages, 8 figures. This is a replacement of supr-con/9608004.
Several sections changed or added, including a section on the effect of spin
and the effect of a conserved number of particles. To be published in Phys.
Rev.
Placement of an aortomonoiliac stent graft without femorofemoral revascularization in endovascular aneurysm repair: a case report
<p>Abstract</p> <p>Introduction</p> <p>Endovascular aortic repair, if technically feasible, is the treatment of choice for patients with a contained ruptured aortic aneurysm who are unfit for open surgery.</p> <p>Case presentation</p> <p>We report the case of an 80-year-old Caucasian man who presented with an unusually configured, symptomatic infrarenal aortic aneurysm. His aneurysm showed an erosion of the fourth lumbar vertebra and a severely arteriosclerotic pelvic axis. A high thigh amputation of his right leg had been performed 15 months previously. On his right side, occlusion of his external iliac artery, common femoral artery, and deep femoral artery had occurred. His aneurysm was treated by a left-sided aortomonoiliac stent graft without femorofemoral revascularization, resulting in occlusions of both internal iliac arteries. No ischemic symptoms appeared, although perfusion of his right side was maintained only over epigastric collaterals.</p> <p>Conclusions</p> <p>The placement of aortomonoiliac stent grafts for endovascular treatment of infrarenal aortic aneurysms without contralateral revascularization is a feasible treatment option in isolated cases. In this report, access problems and revascularization options in endovascular aneurysm repair are discussed.</p
Splenomegaly, elevated alkaline phosphatase and mutations in the SRSF2/ASXL1/RUNX1 gene panel are strong adverse prognostic markers in patients with systemic mastocytosis
We evaluated the impact of clinical and molecular characteristics on overall survival (OS) in 108 patients with indolent (n=41) and advanced SM (advSM, n=67). Organomegaly was measured by magnetic resonance imaging (MRI)-based volumetry of liver and spleen. In multivariate analysis of all patients, an increased spleen volume greater than or equal to450?ml (hazard ratio [HR], 5.2; 95% confidence interval [CI], [2.1–13.0]; P=0.003) and an elevated alkaline phosphatase (AP; HR 5.0 [1.1–22.2]; P=0.02) were associated with adverse OS. The 3-year OS was 100, 77, and 39%, respectively (P<0.0001), for patients with 0 (low-risk, n=37), 1 (intermediate-risk, n=32) or 2 (high-risk, n=39) parameters. For advSM patients with fully available clinical and molecular data (n=60), univariate analysis identified splenomegaly greater than or equal to1200?ml, elevated AP and mutations in the SRSF2/ASXL1/RUNX1 (S/A/R) gene panel as significant prognostic markers. In multivariate analysis, mutations in S/A/R (HR, 3.2 [1.1–9.6]; P=0.01) and elevated AP (HR 2.6 [1.0–7.1]; P=0.03) remained predictive adverse prognostic markers for OS. The 3-year OS was 76% and 38%, respectively (P=0.0003), for patients with 0-1 (intermediate-risk, n=28) or 2 (high-risk, n=32) parameters. We conclude that splenomegaly, elevated AP and mutations in the S/A/R gene panel are independent of the WHO classification and provide the most relevant prognostic information in SM patient
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