Project report: Evaluation of two post-graduate pre-registration nursing modules ‘Finding the Blend’: An evaluation of the balance between online and face to face learning and teaching in a blended curriculum

In the School of Health Sciences we have adopted a blended learning approach for the delivery of the current nursing curriculum. It is intended to enhance and extend the learning opportunities for students. This approach makes full use of available learning technologies whilst recognising the value of face to face interaction and facilitation. It fosters supportive and collaborative learning networks amongst students and encourages deep learning by engaging students in incremental learning tasks and, student directed learning. It also enables students to self- pace their learning. As our nursing programme is being implemented we have engaged both academics and students in a systematic and iterative evaluation of the blended aspects of the programme. Our aims were to: a) Investigate how students experience the current balance between their classroom and online activities b) Evaluate the effectiveness of the range of activities, both online and face to face c) Identify points of good practice based on project evaluation and available literature. In this paper we share the results of our evaluation and highlight key messages for further development and improvement of designing the ‘blend’. Our recommendations may be beneficial for design teams who may need to engage in similar projects in the future

The importance of radio sources in accounting for the highest mass black holes

The most massive black holes lie in the most massive elliptical galaxies, and at low-z all radio-loud AGNs lie in giant ellipticals. This strongly suggests a link between radio-loudness and black hole mass. We argue that the increase in the radio-loud fraction with AGN luminosity in optically-selected quasar samples is consistent with this picture. We also use the ratio of black holes today to quasars at z~2 to conclude that the most bolometrically-luminous AGN, either radio-loud or radio quiet, are constrained to have lifetimes <~10^8 yr. If radio sources are associated with black holes of >~10^9 M_sun at all redshifts, then the same lifetime constraint applies to all radio sources with luminosities above L_5GHz ~ 10^24 W/Hz/sr.Comment: 6 pages, 2 figures. To appear in "Lifecycles of Radio Galaxies", ed J. Biretta et al., New Astronomy Review

On Star Formation and the Non-Existence of Dark Galaxies

We investigate whether a baryonic dark galaxy or `galaxy without stars' could persist indefinitely in the local universe, while remaining stable against star formation. To this end, a simple model has been constructed to determine the equilibrium distribution and composition of a gaseous protogalactic disk. Specifically, we determine the amount of gas that will transit to a Toomre unstable cold phase via the H2 cooling channel in the presence of a UV--X-ray cosmic background radiation field. All but one of the models are predicted to become unstable to star formation. Moreover, we find that all our model objects would be detectable via HI line emission, even in the case that star formation is potentially avoided. These results are consistent with the non-detection of isolated extragalactic HI clouds with no optical counterpart (galaxies without stars) by HIPASS. Additionally, where star formation is predicted to occur, we determine the minimum interstellar radiation field required to restore gravothermal stability, which we then relate to a minimum global star formation rate. This leads to the prediction of a previously undocumented relation between HI mass and star formation rate that is observed for a wide variety of dwarf galaxies in the HI mass range 10^8--10^10 M_sun. The existence of such a relation strongly supports the notion that the well observed population of dwarf galaxies represent the minimum rates of self-regulating star formation in the universe. (Barely abridged)Comment: 19 pages, 8 figures, TeX using emulateapj.cls, v2 accepted for publication in ApJ (16/8/5) with one figure deleted and a number of minor clarifying revision

Variation in the activities of late stage filaggrin processing enzymes, calpain-1 and bleomycin hydrolase, together with pyrrolidone carboxylic acid levels, corneocyte phenotypes and plasmin activities in non-sun-exposed and sun-exposed facial stratum corneum of different ethnicities

BACKGROUND: Knowledge of the ethnic differences and effects of photodamage on the relative amounts of natural moisturizing factor (NMF) together with filaggrin processing enzymes in facial stratum corneum is limited. Our aim was to characterize the activities of calpain-1 (C-1), bleomycin hydrolase (BH) and the levels of pyrrolidone carboxylic acid (PCA) as a marker for total NMF levels and to relate them to plasmin activities and corneocyte maturation. METHODS: Enzyme activities, PCA levels and corneocyte maturation were determined from facial tape strippings of photoexposed cheek and photoprotected post-auricular areas (PA) of healthy Caucasian (C), Black African (BA) and albino African (AA) female subjects living in South Africa. RESULTS: PCA concentration levels were of the order AA > BA > C subjects, and the highest activities of BH were present in the AA subjects. BH activities were greater on the photoexposed sites for the BA and C subjects, but they were only numerically elevated in the AA subjects. Photoprotected sites had an increase in C-1 activity in pigmented groups (C and BA), whereas in the AA subjects, the opposite was measured. Plasmin activities were greater on the cheek compared with the PA site for the AA and C subjects, but the activity was low in the BA subjects. In both test sites, the AA, but not the BA and C subjects, had smaller, parakeratotic and less mature corneocytes. CONCLUSION: Variation in PCA levels has been found for different ethnic groups in this study (AA > BA > C subjects). The values in the AA subjects are surprising as one might expect that the lack of pigmentation, and thereby increased photodamage, might lead to lower levels. Increased BH, but not C-1 activity, was observed in the AA subjects indicating that BH is associated with PCA production to a greater extent. Surprisingly, corneocyte maturation is still impaired with elevated PCA levels in AA subjects. The higher levels of plasmin and BH activities on the cheeks, especially for AA and C subjects, suggest that they can be used as markers for epidermal photodamage

Shocked Molecular Hydrogen in the 3C 326 Radio Galaxy System

The Spitzer spectrum of the giant FR II radio galaxy 3C 326 is dominated by very strong molecular hydrogen emission lines on a faint IR continuum. The H2 emission originates in the northern component of a double-galaxy system associated with 3C 326. The integrated luminosity in H2 pure-rotational lines is 8.0E41 erg/s, which corresponds to 17% of the 8-70 micron luminosity of the galaxy. A wide range of temperatures (125-1000 K) is measured from the H2 0-0 S(0)-S(7) transitions, leading to a warm H2 mass of 1.1E9 Msun. Low-excitation ionic forbidden emission lines are consistent with an optical LINER classification for the active nucleus, which is not luminous enough to power the observed H2 emission. The H2 could be shock-heated by the radio jets, but there is no direct indication of this. More likely, the H2 is shock-heated in a tidal accretion flow induced by interaction with the southern companion galaxy. The latter scenario is supported by an irregular morphology, tidal bridge, and possible tidal tail imaged with IRAC at 3-9 micron. Unlike ULIRGs, which in some cases exhibit H2 line luminosities of comparable strength, 3C 326 shows little star-formation activity (~0.1 Msun/yr). This may represent an important stage in galaxy evolution. Starburst activity and efficient accretion onto the central supermassive black hole may be delayed until the shock-heated H2 can kinematically settle and coolComment: 27 pages, 7 figures, accepted for publication in the Astrophysical Journa

A fundamental investigation into aspects of the physiology and biochemistry of the stratum corneum in subjects with sensitive skin

BACKGROUND: Sensitive skin is a poorly understood skin condition. Defects in stratum corneum (SC) barrier function and/or extrasensory neuronal networks in the epidermis are believed to be involved in the problem. OBJECTIVES: This study aimed to unravel the relationships between bleomycin hydrolase (BH) and calpain-1 (C-1), pyrrolidone carboxylic acid (PCA) levels, corneocyte maturation, transglutaminase (TG) and plasmin activities on the cheeks of subjects with sensitive skin. METHODS: Forty-eight female Caucasian subjects, Fitzpatrick skin phototypes II-III, with self - perceived sensitive facial skin were assessed and underwent a capsaicin reactivity test. Expert grading of skin condition was conducted as well as measurement of transepidermal water loss (TEWL), skin capacitance, SC cohesion and SC integrity. BH, C-1 and plasmin activities were measured as well as PCA levels, plasmin and TG activity. Differential Nile red and involucrin immunostaining was performed to assess corneocyte maturation and size. RESULTS: 52% of the subjects reacted to capsaicin. There were no significant differences between the capsaicin-sensitive and non-capsaicin-sensitive subjects with reference to skin grading, TEWL, skin capacitance and SC cohesion. PCA levels and BH activity were lowest in the capsaicin-sensitive panel (p<0.05) and were correlated in non-capsaicin-sensitive subjects (r = 0.72). The activity of TG was significantly lower (48%) in the capsaicin-sensitive subjects (p<0.001) and their corneocytes were less mature and smaller (p ≤ 0.03). SC was estimated to be thinner (6.87 ± 0.28 vs. 8.68 ± 0.26 μm; p=0.001) in the capsaicin-sensitive subjects with a corresponding shorter SC path length (83.2± 4.4 μm and. 113.1 ± 4.5 μm; p=0.001). CONCLUSIONS: Despite the physiological similarities between the two groups of sensitive skin subjects, differences in their biochemistry were clearly evident. Lower levels of PCA, BH and TG activities together with a greater number of smaller and immature corneocytes indicate inferior SC maturation in the capsaicin-sensitive subjects. The reduced maturation of corneocytes and thinner SC likely contributes to a greater penetration of capsaicin and the associated increased skin sensitivity

Photobase Generator Enabled Pitch Division: A Progress Report

Pitch division lithography (PDL) with a photobase generator (PBG) allows printing of grating images with twice the pitch of a mask. The proof-of-concept has been published in the previous paper[1, 2] and demonstrated by others[1]. Forty five nm half-pitch (HP) patterns were produced using a 90nm HP mask, but the image had line edge roughness (LER) that does not meet requirements. Efforts have been made to understand and improve the LER in this process. Challenges were summarized toward low LER and good performing pitch division. Simulations and analysis showed the necessity for an optical image that is uniform in the z direction in order for pitch division to be successful. Two-stage PBGs were designed for enhancement of resist chemical contrast. New pitch division resists with polymer-bound PAGs and PBGs, and various PBGs were tested. This paper focuses on analysis of the LER problems and efforts to improve patterning performance in pitch division lithography.Chemical Engineerin

HST, radio and infrared observations of 28 3CR radio galaxies at redshift z ~ 1: I. Old stellar populations in central cluster galaxies

Hubble Space Telescope images of 3CR radio galaxies at redshifts 0.6 < z < 1.8 have shown a remarkable variety of structures, generally aligned along the radio axis, indicating that the radio source strongly influences the optical appearance of these galaxies. In this paper we investigate the host galaxies underlying this aligned emission, combining the HST data with ground-based infrared images. An investigation of the spectral energy distributions of the galaxies shows that the contribution of the aligned blue component to the K--band light is generally small (about 10%). The radial intensity profiles of the galaxies are well matched at radii <~ 35 kpc by de Vaucouleurs' law, demonstrating that the K--band light is dominated by that of an elliptical galaxy. There is no evidence for a nuclear point source, in addition to the de Vaucouleurs profile, with a contribution >~15% of the total K--band flux density, except in two cases, 3C22 and 3C41. Large characteristic radii are derived, indicating that the 3CR galaxies must be highly evolved dynamically, even at a redshift of one. At radii > 35 kpc, a combined galaxy profile clearly shows an excess of emission reminiscent of cD--type halos. This supports other independent evidence for the hypothesis that the distant 3CR galaxies lie in moderately rich (proto--)clusters. Since the nearby FR II galaxies in the 3CR catalogue lie in more diffuse environments and do not possess cD halos, the galactic environments of the 3CR galaxies must change with redshift. The K-z relation of the 3CR galaxies cannot, therefore, be interpreted using a standard `closed-box, passive stellar evolution' model. We offer a new interpretation, and compare the model with the K-z relations of lower power radio galaxies and brightest cluster galaxies. (abridged)Comment: 21 pages including 13 figures, LaTeX. To appear in MNRA