7,613 research outputs found
Recommended from our members
Service users as peer research interviewers: why bother?
Drawing on two studies completed within the social housing sector, this chapter asks if there are advantages to peer interviewing, whereby those currently or recently receiving services interview their peers as part of a research project. Contribution is made to the broader methodological debate of how service users should be involved in research about their lives. Along with contributions from a peer interviewer, we examine the benefits to peer interviewers themselves, and whether there are any positive differences for the people being interviewed. This chapter argues that there are clear methodological advantages to peer interviewing as it can lend vital insights from rapport with those often regarded as âhardest to reachâ. The chapter also discusses peer interviewing in terms of strategic risk and limitations, as well as practical and ethical considerations. Ways of developing peer research in general are also suggested
G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling
Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths and limitations of this new model system. G-protein coupled receptors (GPCRs) are key regulators of stem cell maintenance and differentiation and have an important role in cardiovascular cell signaling. In this review, we will therefore describe the state of knowledge concerning the regulatory role of GPCRs in both the generation and function of pluripotent stem cell derived-cardiomyocytes, -endothelial, and -vascular smooth muscle cells. We will consider how far the in vitro disease models recapitulate authentic GPCR signaling and provide a useful basis for discovery of disease mechanisms or design of therapeutic strategies
Constraints on the Growth and Spin of the Supermassive Black Hole in M32 From High Cadence Visible Light Observations
We present 1-second cadence observations of M32 (NGC221) with the CHIMERA
instrument at the Hale 200-inch telescope of the Palomar Observatory. Using
field stars as a baseline for relative photometry, we are able to construct a
light curve of the nucleus in the g-prime and r-prime band with 1sigma=36
milli-mag photometric stability. We derive a temporal power spectrum for the
nucleus and find no evidence for a time-variable signal above the noise as
would be expected if the nuclear black hole were accreting gas. Thus, we are
unable to constrain the spin of the black hole although future work will use
this powerful instrument to target more actively accreting black holes. Given
the black hole mass of (2.5+/-0.5)*10^6 Msun inferred from stellar kinematics,
the absence of a contribution from a nuclear time-variable signal places an
upper limit on the accretion rate which is 4.6*10^{-8} of the Eddington rate, a
factor of two more stringent than past upper limits from HST. The low mass of
the black hole despite the high stellar density suggests that the gas liberated
by stellar interactions was primarily at early cosmic times when the low-mass
black hole had a small Eddington luminosity. This is at least partly driven by
a top-heavy stellar initial mass function at early cosmic times which is an
efficient producer of stellar mass black holes. The implication is that
supermassive black holes likely arise from seeds formed through the coalescence
of 3-100 Msun mass black holes that then accrete gas produced through stellar
interaction processes.Comment: 8 pages, 3 figures, submitted to the Astrophysical Journal, comments
welcom
Striatal D1 and D2 receptor binding in patients with Huntington's disease and other choreas. A PET study
Resistance of superconducting nanowires connected to normal metal leads
We study experimentally the low temperature resistance of superconducting
nanowires connected to normal metal reservoirs. We find that a substantial
fraction of the nanowires is resistive, down to the lowest temperature
measured, indicative of an intrinsic boundary resistance due to the
Andreev-conversion of normal current to supercurrent. The results are
successfully analyzed in terms of the kinetic equations for diffusive
superconductors
Antimatter spectra from a time-dependent modeling of supernova remnants
We calculate the energy spectra of cosmic rays (CR) and their secondaries
produced in a supernova remnant (SNR), taking into account the time-dependence
of the SNR shock. We model the trajectories of charged particles as a random
walk with a prescribed diffusioncoefficient, accelerating the particles at each
shock crossing. Secondary production by CRs colliding with gas is included as a
Monte Carlo process. We find that SNRs produce less antimatter than suggested
previously: The positron/electron ratio and the antiproton/proton ratio are a
few percent and few , respectively. Both ratios do not rise
with energy.Comment: 4 pages, 4 eps figures; v2: results for time-dependent magnetic field
adde
Exposure of benthic invertebrates to sediment vibration: From laboratory experiments to outdoor simulated pile-driving
Activities directly interacting with the seabed, such as pile-driving, can produce vibrations that have the potential to impact benthic invertebrates within their vicinity. This stimuli may interfere with crucial behaviors such as foraging and predator avoidance, and the sensitivity to vibration is largely unknown. Here, the responsiveness of benthic invertebrates to sediment vibration is discussed in relation to laboratory and semi-field trials with two marine species: the mussel (Mytilus edulis) and hermit crab (Pagurus bernhardus). Sensory threshold curves were produced for both species in controlled laboratory conditions, followed by small-scale pile-driving exposures in the field. The merits of behavioral indicators are discussed, in addition to using physiological measures, as a method of determining reception and measuring responses. The measurement and sensors required for sediment vibration quantification are also discussed. Response and threshold data were related to measurements taken in the vicinity of anthropogenic sources, allowing a link between responsiveness and actual operations. The impact of pile-driving on sediment-dwelling invertebrates has received relatively little research, yet the data here suggest that such activities are likely to impact key coastal species which play important roles within the marine environment
Superfluid Friction and Late-time Thermal Evolution of Neutron Stars
The recent temperature measurements of the two older isolated neutron stars
PSR 1929+10 and PSR 0950+08 (ages of and yr,
respectively) indicate that these objects are heated. A promising candidate
heat source is friction between the neutron star crust and the superfluid it is
thought to contain. We study the effects of superfluid friction on the
long-term thermal and rotational evolution of a neutron star. Differential
rotation velocities between the superfluid and the crust (averaged over the
inner crust moment of inertia) of rad s for PSR
1929+10 and rad s for PSR 0950+08 would account for their
observed temperatures. These differential velocities could be sustained by
pinning of superfluid vortices to the inner crust lattice with strengths of
1 MeV per nucleus. Pinned vortices can creep outward through thermal
fluctuations or quantum tunneling. For thermally-activated creep, the coupling
between the superfluid and crust is highly sensitive to temperature. If pinning
maintains large differential rotation ( rad s), a feedback
instability could occur in stars younger than yr causing
oscillations of the temperature and spin-down rate over a period of . For stars older than yr, however, vortex creep occurs
through quantum tunneling, and the creep velocity is too insensitive to
temperature for a thermal-rotational instability to occur. These older stars
could be heated through a steady process of superfluid friction.Comment: 26 pages, 1 figure, submitted to Ap
- âŠ