Interspecies reactivity and intraspecies specificity of antilymphoid globulin

Horse antihuman and antidog antilymphocyte globulins were shown to possess leukoagglutinating antibodies when tested against the white cells from a number of other divergent species. In addition, the white cells of individuals within the species against which immunization was originally conducted were variably affected by the immune globulin. The latter observation suggests that these globulins could be more effective in some cases than in others if they were used therapeutically for their immunosuppressive qualities. © 1967

An Evaluation Method for Context-Aware Systems in U-Health

Proceedings of: 3rd International Symposium on Ambient Intelligence (ISAmI 2012) Salamanca, March 28-30, 2012Evaluations for context-aware systems can not be conducted in the same manner evaluation is understood for other software systems where the concept of large corpus data, the establishment of ground truth and the metrics of precision and recall are used. Evaluation for changeable systems like context-aware and specially developed for AmI environments needs to be conducted to assess the impact and awareness of the users. E-Health represents a challenging domain where users(patients, patients' relatives and healthcare professionals) are very sensitive to systems' response. If system failure occurs it can conducts to a bad diagnosis or medication, or treatment. So a user-centred evaluation system is need to provide the system with users' feedback. In this paper, we present an evaluation method for context aware systems in AmI environments and specially to u-Heatlh domainFunded by projects CICYT TIN2008-06742-C02-02/TSI, CICYTTEC2008-06732 C02-02/TEC, SINPROB, CAM MADRINET S-0505/TIC/0255 and DPS2008-07029-C02-02.Publicad

Pathogenesis, risk factors and therapeutic options for autoimmune haemolytic anaemia in the post-transplant setting

Autoimmune haemolytic anaemia (AIHA) is a rare complication of allogeneic haematopoietic stem cell transplantation (HSCT), observed with an incidence of 1–5%. Paediatric age, diagnosis of non-malignant disease, lympho-depleting agents in the conditioning regimen, use of unrelated donor, graft versus host disease and infections have been associated with a higher risk of AIHA post HSCT. Post-HSCT AIHA is associated with high mortality and morbidity, and it is often very difficult to treat. Steroids and rituximab are used with a response rate around 30–50%. These and other therapeutic strategies are mainly derived from data on primary AIHA, although response rates in post-HSCT AIHA have been generally lower. Here we review the currently available data on risk factors and therapeutic options. There is a need for prospective studies in post-HSCT AIHA to guide clinicians in managing these complex patients

Alteration of post harvest diseases of mango Mangifera indica through production practices and climatic factors

Mango production in Senegal takes place over the two seasons of dry and humid conditions between April and November. The increasing demand for fresh mangoes has led to an increase in land areaallocated to that crop. Mango production suffers, however, from fruit rotting due to post-harvest diseases during ripening. These diseases reduce the fruit quality and cause severe losses. A surveywas carried out in 2004 to detect fungi involved in post-harvest rot of mangoes (cv. Kent) produced in the Niayes area of Senegal in relation with the production practices and the climatic conditions. Theresults showed that at first harvest during the dry season, a broader species range of fungi including Alternaria sp., Botryodiplodia theobromae, Dothiorella sp., Aspergillus niger and non-identified fungiwere responsible for mango rotting. The fruits harvested during the humid season, however, were more heavily infested but a smaller number of fungal agents were involved; Colletotrichum gloeosporioidesand secondarily Phoma mangiferae played the main role. The cultural practices played an important role on mango infection whereby orchard sanitation and particularly cleaning and pruning reduced theinfection rates. Orchards with no care, in contrast, yielded the most heavily infested mango samples. In addition, the harvest practice of inversion of fruits in soil for sap elimination increases contaminationwith pathogenic fungi

Funkcional za tvorbu vezanih stanja u QED

The manifestly Lorentz covariant formulation of quantum electrodynamics disregards Coulomb instantaneous interaction and its consequence - instantaneous bound states (IBS\u27s). In this article we consider the way of construction the IBS generating functional using the operator generalization of the initial data in the Dirac Hamiltonian approach to QED.Očito Lorentz-kovariantna formulacija kvantne elektrodinamike zanemaruje trenutno Coulombovo međudjelovanje i njegovu posljedicu – trenutna vezana stanja. U ovom se radu razmatra postavljanje tvorbenog funkcionala za trenutno vezana stanja primjenom operatora poopćenih početnih stanja u Dirac-Hamiltonovom pristupu QED

Impact of Kidney Function on Cardiovascular Risk and Mortality: A Comparison of South Asian and European Cohorts

BACKGROUND: Evidence is limited on ethnic differences in associations between kidney function markers and mortality or cardiovascular disease (CVD). METHODS: Baseline cross-sectional analysis and longitudinal follow-up study of a UK population-based cohort of 1,116 Europeans and 1,104 South Asians of predominantly Indian descent, age 52 ± 7 years at baseline (1988-1991). Kidney function was estimated using Cystatin C and creatinine-based chronic kidney disease (CKD) Epidemiology Collaboration estimated glomerular filtration rate (eGFR) equations, and urinary albumin-creatinine ratio (ACR). Mortality was captured at 27 years, and incident CVD at 22 years, from death certification, medical records and participant report. Longitudinal associations between eGFR/ACR and mortality/incident CVD were examined using Cox models. RESULTS: eGFRcys was lower and ACR higher in South Asians than Europeans. eGFRcys and -eGFRcreat were more strongly associated with outcomes in Europeans than South Asians. Conversely, associations between ACR and outcomes were greater in South Asians than Europeans, for example, for CVD mortality: HRs (95% CI) adjusted for CVD risk factors and ACR/eGFRcys as appropriate, p for ethnicity interaction: eGFRcys: Europeans: 0.76 (0.62-0.92), South Asians: 0.92 (0.78-1.07), p = 0.05, eGFRcreat: Europeans 0.81 (0.67-0.99), South Asians 1.18 (0.97-1.41), p = 0.002, ACR: -Europeans: 1.24 (1.08-1.42), South Asians: 1.39 (1.25-1.57), p= 0.23. Addition of all CKD measures to a standard CVD risk factor model modestly improved prediction capability in -Europeans; in South Asians only ACR contributed to improvement. CONCLUSIONS: Strong associations between ACR and outcomes in South Asians of predominantly Indian origin, and null associations for eGFRcys and eGFRcreat, suggest that ACR may have greater utility in CVD risk prediction in South Asians. Further work is needed to validate these findings

Applications of Satellite Earth Observations section - NEODAAS: Providing satellite data for efficient research

The NERC Earth Observation Data Acquisition and Analysis Service (NEODAAS) provides a central point of Earth Observation (EO) satellite data access and expertise for UK researchers. The service is tailored to individual users’ requirements to ensure that researchers can focus effort on their science, rather than struggling with correct use of unfamiliar satellite data

Funkcional za tvorbu vezanih stanja u QED

The manifestly Lorentz covariant formulation of quantum electrodynamics disregards Coulomb instantaneous interaction and its consequence - instantaneous bound states (IBS\u27s). In this article we consider the way of construction the IBS generating functional using the operator generalization of the initial data in the Dirac Hamiltonian approach to QED.Očito Lorentz-kovariantna formulacija kvantne elektrodinamike zanemaruje trenutno Coulombovo međudjelovanje i njegovu posljedicu – trenutna vezana stanja. U ovom se radu razmatra postavljanje tvorbenog funkcionala za trenutno vezana stanja primjenom operatora poopćenih početnih stanja u Dirac-Hamiltonovom pristupu QED