Interleukins Associated with Brews Cancer

A tumor consists of a group of cells with abnormal growth, capable of acquiring unique characteristics that provide them with the ability to display mercurial migration patterns, adapting to microenvironments and their chemical and physical factors. Interleukins are small proteins secreted mainly by CD3+ and CD4+ T lymphocytes that mediate the “essential for cancer progression” interactions between cells. Interleukins are implicated in both the development and differentiation of different cells (NK, B, and T leukocytes) and, in general, play a major role in many diseases, including breast cancer, due to their unique participation in systemic inflammation and immune system modulation. During the past decade, interleukins proved to be decisive for future immunotherapy, predisposing a more reliable treatment with fewer side effects on normal proliferating cells. The aim of this review is to provide an overview of the role of interleukins implicated in breast cancer progression

The devastating effects of neoplasia in the vulnerable childhood

Cancer accounts for 20% of the causes of death and occupies the second place as a reason of mortality after cardiovascular disease, but the incidence of childhood cancer is little (less than 1% of new cases in western populations). However, in many countries, it is the second or third cause of death in children. All around the world, the main reasons causing death in children are accidents and inadequate nutrition. In countries where this trend has declined, cancer has become the leading cause of death in this young population. Almost 50% of malignancies occur in children aged 0-5 years.Today, cancer is considered a threatening disease for both children and adolescents, but not always fatal. However, not only is it essential to cure the biological cognition but also the psychological (i.e. to know that the child or teenager is suffering from cancer) and the social aspect (the reintegration of the child and adolescent into society without stigma). The scope of this study is to investigate the current clinical and psychological management of young patients and children in order to reintegrate children and adolescents into the social life smoothly

Objective assessment of instability indices for operational hail forecasting in Greece

Summarization: This paper examines the performance of several atmospheric instability indices for operational hail forecasting in the Greek National Hail Suppression Program (GNHSP). These indices are part of the adopted forecasting procedure in the GNHSP, which also involves a synoptic index of convection and a synoptic scale typing scheme. The assessment of the indices is accomplished objectively through a multivariate statistical technique, namely factor analysis. The analysis resulted in grouping of the indices into three factors. The indices with high loading and scores are considered to best detect convection for hail forecasting in the GNHSP.Presented on: Meteorology and Atmospheric Physic

The Role of microRNAs Identified in the Amniotic Fluid.

AIM: The study aimed to provide an overall view of current data considering the presence of microRNAs in amniotic fluid. METHODS: The available literature in MEDLINE, regarding the role of the amniotic fluid in pregnancy and fetal development, was searched for related articles including terms such as "microRNA", "Amniotic fluid", "Adverse outcome" and others. RESULTS: The amniotic fluid has an undoubtedly significant part in fetal nutrition, with a protecting and thermoregulatory role alongside. MicroRNAs have proven to be highly expressed during pregnancy in many body liquids including amniotic fluid and are transferred between cells loaded in exosomes, while they are also implicated in many processes during fetal development and could be potential biomarkers for early prediction of adverse outcomes. CONCLUSION: Current knowledge reveals that amniotic fluid microRNAs participate in many developmental and physiological processes of pregnancy including proliferation of fibroblasts, fetal development, angiogenesis, cardioprotection, activation of signaling pathways, differentiation and cell motility, while the expression profile of specific microRNAs has a potential prognostic role in the prediction of Down syndrome, congenital hydronephrosis and kidney fibrosis

Association of Pregestational Maternal Sleeping Disorders and Preeclampsia: A Retrospective Cohort Study and Review of the Literature

In this retrospective cohort study, primigravidas with normal pregnancies and women who developed preeclampsia (PE) were assigned to complete sleeping disorder questionnaires. The Crown-Rump length (CRL) of the first prenatal screening was used to determine the gestational age and the participants were assigned to complete the following questionnaires according to their everyday life before pregnancy: (1) Pittsburgh Sleep Quality Index (PSQI), (2) Epworth Sleepiness Scale (ESS), and (3) Athens Insomnia Scale (AIS). Women were also asked to evaluate their stress before pregnancy with the Beck Anxiety Inventory (BAI). The results of the women developing preeclampsia were analyzed to test the primary hypothesis that women with preexisting to pregnancy sleep disorders are more likely to develop preeclampsia. Statistically significant differences were found between women who developed preeclampsia and women in the control group concerning sleeping disorder features before pregnancy of all three research tools, namely AIS (p< 0.001), PSQI (p< 0.001), and ESS (p=0.012<0.05). The results support that there is a possible statistical effect of pre-existing to pregnancy sleep disorders on the development of preeclampsia and women with pregestational sleep disorders request strict monitoring during pregnancy, however, further investigation with larger studies is needed to reach safe conclusions