Vibrophonocardiograph Patent

Vibrophonocardiograph comprising low weight and small volume piezoelectric microphone with amplifier having high imput impedance for high sensitivity and low frequency respons

What's the evidence that NICE guidance has been implemented? Results from a national evaluation using time series analysis, audit of patients' notes, and interviews

OBJECTIVES: To assess the extent and pattern of implementation of guidance issued by the National Institute for Clinical Excellence (NICE). DESIGN: Interrupted time series analysis, review of case notes, survey, and interviews. SETTING: Acute and primary care trusts in England and Wales. PARTICIPANTS: All primary care prescribing, hospital pharmacies; a random sample of 20 acute trusts, 17 mental health trusts, and 21 primary care trusts; and senior clinicians and managers from five acute trusts. MAIN OUTCOME MEASURES: Rates of prescribing and use of procedures and medical devices relative to evidence based guidance. RESULTS: 6308 usable patient audit forms were returned. Implementation of NICE guidance varied by trust and by topic. Prescribing of some taxanes for cancer (P <0.002) and orlistat for obesity (P <0.001) significantly increased in line with guidance. Prescribing of drugs for Alzheimer’s disease and prophylactic extraction of wisdom teeth showed trends consistent with, but not obviously a consequence of, the guidance. Prescribing practice often did not accord with the details of the guidance. No change was apparent in the use of hearing aids, hip prostheses, implantable cardioverter defibrillators, laparoscopic hernia repair, and laparoscopic colorectal cancer surgery after NICE guidance had been issued. CONCLUSIONS: Implementation of NICE guidance has been variable. Guidance seems more likely to be adopted when there is strong professional support, a stable and convincing evidence base, and no increased or unfunded costs, in organisations that have established good systems for tracking guidance implementation and where the professionals involved are not isolated. Guidance needs to be clear and reflect the clinical context

Synthetic magnetism for photon fluids

We develop a theory of artificial gauge fields in photon fluids for the cases of both second-order and third-order optical nonlinearities. This applies to weak excitations in the presence of pump fields carrying orbital angular momentum, and is thus a type of Bogoliubov theory. The resulting artificial gauge fields experienced by the weak excitations are an interesting generalization of previous cases and reflect the PT-symmetry properties of the underlying non-Hermitian Hamiltonian. We illustrate the observable consequences of the resulting synthetic magnetic fields for examples involving both second-order and third-order nonlinearities

Evidence for extended IR emission in NGC2798 and NGC6240

Extended emission at 10 and 20 microns can be used to distinguish starbursts from monsters as the underlying energy source driving the luminous infrared emission in the central regions of galaxies. The spatial extent of the mid infrared emission in the interacting galaxy NCG 2798 and the merger NGC 6240 were investigated. The 10 and 20 micron profiles of the IR source in NGC 2798 are significantly wider than beam profiles measured on a standard star, supporting a starburst interpretation of its IR luminosity. For NGC 6240 there is marginal evidence for an extended 10 micron source, suggesting that a significant fraction of its IR luminosity could be produced by a burst of star formation

Space station integrated wall design and penetration damage control

A methodology was developed to allow a designer to optimize the pressure wall, insulation, and meteoroid/debris shield system of a manned spacecraft for a given spacecraft configuration and threat environment. The threat environment consists of meteoroids and orbital debris, as specified for an arbitrary orbit and expected lifetime. An overall probability of no penetration is calculated, as well as contours of equal threat that take into account spacecraft geometry and orientation. Techniques, tools, and procedures for repairing an impacted and penetrated pressure wall were developed and tested. These techniques are applied from the spacecraft interior and account for the possibility of performing the repair in a vacuum. Hypervelocity impact testing was conducted to: (1) develop and refine appropriate penetration functions, and (2) determine the internal effects of a penetration on personnel and equipment