Genomic characterisation of human monkeypox virus in Nigeria

Monkeypox virus (MPXV) is a large, double-stranded DNA virus belonging to the Orthopox genus in the family Poxviridae. First identified in 1958, MPXV has caused sporadic human outbreaks in central and west Africa, with a mortality rate between 1% and 10%.1 Viral genomes from west Africa and the Congo Basin separate into two clades, the latter being more virulent.2 Recently, MPXV outbreaks have occurred in Sudan (2005), the Republic of the Congo and Democratic Republic of the Congo (2009), and the Central African Republic (2016).3 A suspected outbreak of human MPXV was reported to WHO on Sept 26, 2017, by the Nigeria Centre for Disease Control (NCDC) after a cluster of suspected cases had occurred in Yenagoa Local Government Area, Bayelsa State, Nigeria.4 Since the onset of the outbreak, 155 cases have been reported by the NCDC, of which 56 were confirmed.4 A subset of these samples was sent to the WHO Collaborating Center at the Institut Pasteur de Dakar (IPD) in Senegal for confirmation by PCR

Pathology of common diseases of the thyroid gland in Port Harcourt

Background: Thyroid diseases are rare in this environment but are more frequent in Western and Northern parts of Nigeria. These diseases present with neck swellings, pains and resulting in high morbidity and mortality rate as well as posing cosmetic problems. Aim: To study the frequency, age distribution and histological types of thyroid diseases. Design/ Setting: A ten-year (1994-2003) retrospective study in Port Harcourt, Nigeria. Methods: Histologic slides were reviewed to ascertain the type of diseases in all cases. The age, sex and clinical presentations were extracted from the histology consultation forms, surgical notes, day books, radiological reports and patient's case file. Results: Thyroid disease accounted for 0.9% of biopsies received during the period under review. The lowest frequency occurred in the ages 0 - 10 and 61 -70 years, with one case (1.3%) each. The highest occurred in the age group 31-40 years, which recorded 31 cases (38.8%). The youngest was a 10 - year old male while the oldest was a 70-year-old female. Eight cases (10.0%) occurred in males while 72 (90.0%) occurred in females giving a female to male sex ratio of 9:1. Metabolic disease (colloid goitre) was the most common, occurring in 42 (52.0%) cases. The least common was inflammatory diseases, 3 (3.8%) cases. The most common clinical presentation was neck mass, 64 (80.0%) cases. Conclusion: This study confirmed the rarity of thyroid diseases in the Port Harcourt environment and colloid goitre was the most frequent disease. The predominance of females needs an elaborate population based study.   Key words:  Thyroid diseases, Goitre, Tumours, Port Harcour

Genomic characterisation of human monkeypox virus in Nigeria

Monkeypox virus (MPXV) is a large, double-stranded DNA virus belonging to the Orthopox genus in the family Poxviridae. First identified in 1958, MPXV has caused sporadic human outbreaks in central and west Africa, with a mortality rate between 1% and 10%.1 Viral genomes from west Africa and the Congo Basin separate into two clades, the latter being more virulent.2 Recently, MPXV outbreaks have occurred in Sudan (2005), the Republic of the Congo and Democratic Republic of the Congo (2009), and the Central African Republic (2016).3 A suspected outbreak of human MPXV was reported to WHO on Sept 26, 2017, by the Nigeria Centre for Disease Control (NCDC) after a cluster of suspected cases had occurred in Yenagoa Local Government Area, Bayelsa State, Nigeria.4 Since the onset of the outbreak, 155 cases have been reported by the NCDC, of which 56 were confirmed.4 A subset of these samples was sent to the WHO Collaborating Center at the Institut Pasteur de Dakar (IPD) in Senegal for confirmation by PCR