What we have learned about policy-research linkage from providing a rapid response facility for international healthcare comparisons to the Department of Health in England

In this paper we reflect on our experience of providing a rapid response facility for international healthcare policy comparisons to the English Department of Health. We examine the challenges of developing sustained relationships with policy officials while providing an 'on-demand' service in an environment with high turnover of policies and staff. It may be easier for policy makers to draw on researchers in such a setting than for researchers to foster 'linkage and exchange' relationships with policy makers. Under the facility, knowledge transfer has mostly been from researchers to policy officials, affording us little insight into the policy process or the impact of our work

Observation of supersymmetric scattering in photonic lattices

Supersymmetric (SUSY) optical structures display a number of intriguing properties that can lead to a variety of potential applications, ranging from perfect global phase matching to highly efficient mode conversion and novel multiplexing schemes. Here, we experimentally investigate the scattering characteristics of supersymmetric photonic lattices. We directly observe the light dynamics in such systems and compare the reflection/transmission properties of SUSY partner structures. In doing so, we demonstrate that discrete settings constitute a promising testbed for studying the different facets of optical supersymmetry.Comment: 8 pages, 4 figure

Supersymmetric mode converters

Originally developed in the context of quantum field theory, the concept of supersymmetry (SUSY) can be used to systematically design a new class of optical structures. In this work, we demonstrate how key features arising from optical supersymmetry can be exploited to control the flow of light for mode division multiplexing applications. Superpartner configurations are experimentally realized in coupled optical networks, and the corresponding light dynamics in such systems are directly observed. We show that SUSY can be judiciously utilized to remove the fundamental mode of a multimode optical structure, while establishing global phase matching conditions for the remaining set of modes. Along these lines, supersymmetry may serve as a promising platform for a new generation of versatile optical components with novel properties and functionalities.Comment: 14 pages, 4 figure

Drosophila simulans: a species with improved resolution in evolve and resequence studies

The combination of experimental evolution with high-throughput sequencing of pooled individuals-i.e., evolve and resequence (E&R)-is a powerful approach to study adaptation from standing genetic variation under controlled, replicated conditions. Nevertheless, E&R studies in Drosophila melanogaster have frequently resulted in inordinate numbers of candidate SNPs, particularly for complex traits. Here, we contrast the genomic signature of adaptation following ∼60 generations in a novel hot environment for D. melanogaster and D. simulans For D. simulans, the regions carrying putatively selected loci were far more distinct, and thus harbored fewer false positives, than those in D. melanogaster We propose that species without segregating inversions and higher recombination rates, such as D. simulans, are better suited for E&R studies that aim to characterize the genetic variants underlying the adaptive response.Neda Barghi, Raymond Tobler, Viola Nolte and Christian Schlöttere