Disaster debris estimation using high-resolution polarimetric stereo-SAR

AbstractThis paper addresses the problem of debris estimation which is one of the most important initial challenges in the wake of a disaster like the Great East Japan Earthquake and Tsunami. Reasonable estimates of the debris have to be made available to decision makers as quickly as possible. Current approaches to obtain this information are far from being optimal as they usually rely on manual interpretation of optical imagery. We have developed a novel approach for the estimation of tsunami debris pile heights and volumes for improved emergency response. The method is based on a stereo-synthetic aperture radar (stereo-SAR) approach for very high-resolution polarimetric SAR. An advanced gradient-based optical-flow estimation technique is applied for optimal image coregistration of the low-coherence non-interferometric data resulting from the illumination from opposite directions and in different polarizations. By applying model based decomposition of the coherency matrix, only the odd bounce scattering contributions are used to optimize echo time computation. The method exclusively considers the relative height differences from the top of the piles to their base to achieve a very fine resolution in height estimation. To define the base, a reference point on non-debris-covered ground surface is located adjacent to the debris pile targets by exploiting the polarimetric scattering information. The proposed technique is validated using in situ data of real tsunami debris taken on a temporary debris management site in the tsunami affected area near Sendai city, Japan. The estimated height error is smaller than 0.6m RMSE. The good quality of derived pile heights allows for a voxel-based estimation of debris volumes with a RMSE of 1099m3. Advantages of the proposed method are fast computation time, and robust height and volume estimation of debris piles without the need for pre-event data or auxiliary information like DEM, topographic maps or GCPs

Gravitational waves from a test particle scattered by a neutron star: Axial mode case

Using a metric perturbation method, we study gravitational waves from a test particle scattered by a spherically symmetric relativistic star. We calculate the energy spectrum and the waveform of gravitational waves for axial modes. Since metric perturbations in axial modes do not couple to the matter fluid of the star, emitted waves for a normal neutron star show only one peak in the spectrum, which corresponds to the orbital frequency at the turning point, where the gravitational field is strongest. However, for an ultracompact star (the radius $R \lesssim 3M$), another type of resonant periodic peak appears in the spectrum. This is just because of an excitation by a scattered particle of axial quasinormal modes, which were found by Chandrasekhar and Ferrari. This excitation comes from the existence of the potential minimum inside of a star. We also find for an ultracompact star many small periodic peaks at the frequency region beyond the maximum of the potential, which would be due to a resonance of two waves reflected by two potential barriers (Regge-Wheeler type and one at the center of the star). Such resonant peaks appear neither for a normal neutron star nor for a Schwarzschild black hole. Consequently, even if we analyze the energy spectrum of gravitational waves only for axial modes, it would be possible to distinguish between an ultracompact star and a normal neutron star (or a Schwarzschild black hole).Comment: 21 pages, revtex, 11 figures are attached with eps files Accepted to Phys. Rev.

Gravitational Waves in Brans-Dicke Theory : Analysis by Test Particles around a Kerr Black Hole

Analyzing test particles falling into a Kerr black hole, we study gravitational waves in Brans-Dicke theory of gravity. First we consider a test particle plunging with a constant azimuthal angle into a rotating black hole and calculate the waveform and emitted energy of both scalar and tensor modes of gravitational radiation. We find that the waveform as well as the energy of the scalar gravitational waves weakly depends on the rotation parameter of black hole $a$ and on the azimuthal angle. Secondly, using a model of a non-spherical dust shell of test particles falling into a Kerr black hole, we study when the scalar modes dominate. When a black hole is rotating, the tensor modes do not vanish even for a ``spherically symmetric" shell, instead a slightly oblate shell minimizes their energy but with non-zero finite value, which depends on Kerr parameter $a$. As a result, we find that the scalar modes dominate only for highly spherical collapse, but they never exceed the tensor modes unless the Brans-Dicke parameter \omega_{BD} \lsim 750 for $a/M=0.99$ or unless \omega_{BD} \lsim 20,000 for $a/M=0.5$, where $M$ is mass of black hole. We conclude that the scalar gravitational waves with \omega_{BD} \lsim several thousands do not dominate except for very limited situations (observation from the face-on direction of a test particle falling into a Schwarzschild black hole or highly spherical dust shell collapse into a Kerr black hole). Therefore observation of polarization is also required when we determine the theory of gravity by the observation of gravitational waves.Comment: 24 pages, revtex, 18 figures are attached with ps file

Epithelial p38α Controls Immune Cell Recruitment in the Colonic Mucosa

Intestinal epithelial cells (IECs) compose the first barrier against microorganisms in the gastrointestinal tract. Although the NF-κB pathway in IECs was recently shown to be essential for epithelial integrity and intestinal immune homeostasis, the roles of other inflammatory signaling pathways in immune responses in IECs are still largely unknown. Here we show that p38α in IECs is critical for chemokine expression, subsequent immune cell recruitment into the intestinal mucosa, and clearance of the infected pathogen. Mice with p38α deletion in IECs suffer from a sustained bacterial burden after inoculation with Citrobacter rodentium. These animals are normal in epithelial integrity and immune cell function, but fail to recruit CD4+ T cells into colonic mucosal lesions. The expression of chemokines in IECs is impaired, which appears to be responsible for the impaired T cell recruitment. Thus, p38α in IECs contributes to the host immune responses against enteric bacteria by the recruitment of immune cells

Receptor for Activated Protein Kinase C: Requirement for Efficient MicroRNA Function and Reduced Expression in Hepatocellular Carcinoma

MicroRNAs (miRNAs) are important regulators of gene expression that control physiological and pathological processes. A global reduction in miRNA abundance and function is a general trait of human cancers, playing a causal role in the transformed phenotype. Here, we sought to newly identify genes involved in the regulation of miRNA function by performing a genetic screen using reporter constructs that measure miRNA function and retrovirus-based random gene disruption. Of the six genes identified, RACK1, which encodes “receptor for activated protein kinase C” (RACK1), was confirmed to be necessary for full miRNA function. RACK1 binds to KH-type splicing regulatory protein (KSRP), a member of the Dicer complex, and is required for the recruitment of mature miRNAs to the RNA-induced silencing complex (RISC). In addition, RACK1 expression was frequently found to be reduced in hepatocellular carcinoma. These findings suggest the involvement of RACK1 in miRNA function and indicate that reduced miRNA function, due to decreased expression of RACK1, may have pathologically relevant roles in liver cancers

DEAD-Box Protein Ddx46 Is Required for the Development of the Digestive Organs and Brain in Zebrafish

Spatially and temporally controlled gene expression, including transcription, several mRNA processing steps, and the export of mature mRNA to the cytoplasm, is essential for developmental processes. It is well known that RNA helicases of the DExD/H-box protein family are involved in these gene expression processes, including transcription, pre-mRNA splicing, and rRNA biogenesis. Although one DExD/H-box protein, Prp5, a homologue of vertebrate Ddx46, has been shown to play important roles in pre-mRNA splicing in yeast, the in vivo function of Ddx46 remains to be fully elucidated in metazoans. In this study, we isolated zebrafish morendo (mor), a mutant that shows developmental defects in the digestive organs and brain, and found that it encodes Ddx46. The Ddx46 transcript is maternally supplied, and as development proceeds in zebrafish larvae, its ubiquitous expression gradually becomes restricted to those organs. The results of whole-mount in situ hybridization showed that the expression of various molecular markers in these organs is considerably reduced in the Ddx46 mutant. Furthermore, splicing status analysis with RT-PCR revealed unspliced forms of mRNAs in the digestive organ and brain tissues of the Ddx46 mutant, suggesting that Ddx46 may be required for pre-mRNA splicing during zebrafish development. Therefore, our results suggest a model in which zebrafish Ddx46 is required for the development of the digestive organs and brain, possibly through the control of pre-mRNA splicing

The p250GAP Gene Is Associated with Risk for Schizophrenia and Schizotypal Personality Traits

BACKGROUND: Hypofunction of the glutamate N-Methyl-d-aspartate (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. p250GAP is a brain-enriched NMDA receptor-interacting RhoGAP. p250GAP is involved in spine morphology, and spine morphology has been shown to be altered in the post-mortem brains of patients with schizophrenia. Schizotypal personality disorder has a strong familial relationship with schizophrenia. Several susceptibility genes for schizophrenia have been related to schizotypal traits. METHODS: We first investigated the association of eight linkage disequilibrium-tagging single-nucleotide polymorphisms (SNPs) that cover the p250GAP gene with schizophrenia in a Japanese sample of 431 schizophrenia patients and 572 controls. We then investigated the impact of the risk genetic variant in the p250GAP gene on schizotypal personality traits in 180 healthy subjects using the Schizotypal Personality Questionnaire. RESULTS: We found a significant difference in genotype frequency between the patients and the controls in rs2298599 (χ(2) = 17.6, p = 0.00015). The minor A/A genotype frequency of rs2298599 was higher in the patients (18%) than in the controls (9%) (χ(2) = 15.5, p = 0.000083). Moreover, we found that subjects with the rs2298599 risk A/A genotype, compared with G allele carriers, had higher scores of schizotypal traits (F(1,178) = 4.08, p = 0.045), particularly the interpersonal factor (F(1,178) = 5.85, p = 0.017). DISCUSSION: These results suggest that a genetic variation in the p250GAP gene might increase susceptibility not only for schizophrenia but also for schizotypal personality traits. We concluded that the p250GAP gene might be a new candidate gene for susceptibility to schizophrenia