Bacterial isolates from neutropenic febrile pediatric patients and their sensitivity patterns to antibiotics

Patients on cytotoxic therapy often develop neutropenia and fever. Our interest was to identify the common pathogens isolated from such patients and to study the sensitivity patterns of these organisms to the antibiotics used in their treatment. Thus, guidelines can be established by hospitals to identify which antibiotics can be used in the treatment of these patients when the results of cultures and sensitivities are not available. We conducted a retrospective study of neutropenic pediatrics presenting to AKUH from July, 1990 to June, 1996. A total of 153 isolates in 35 different patients were studied. Samples for culture were taken from the sites at risk. The majority of samples consisted of blood, stool, pus and urine. Twenty stool samples were also sent for microscopy. Malignancies were both hematological and non-hematological. Gram negatives were isolated in 52.9%, gram positives in 33.9% and parasites in 13.2%. Salmonella paratyphi B was the most commonly isolated organism, followed by Pseudomonas aeroginosa, Giardia lamblia was the most common parasite. Sensitivity patterns of these organisms to antibiotics studied showed that Escheria coli had the lowest sensitivity rate being only 40% sensitive to Aztreonam and 64% sensitive to Ofloxacillin. A comparison was made between our findings and those reported in literature, as well as the risk factors for developing neutropenia. A guide to management is also discussed

Mucinous cystic neoplasms of the mesentery: a case report and review of the literature

<p>Abstract</p> <p>Background</p> <p>Mucinous cystic neoplasms arise in the ovary and various extra-ovarian sites. While their pathogenesis remains conjectural, their similarities suggest a common pathway of development. There have been rare reports involving the mesentery as a primary tumour site.</p> <p>Case presentation</p> <p>A cystic mass of uncertain origin was demonstrated radiologically in a 22 year old female with chronic abdominal pain. At laparotomy, the mass was fixed within the colonic mesentery. Histology demonstrated a benign mucinous cystadenoma.</p> <p>Methods and results</p> <p>We review the literature on mucinous cystic neoplasms of the mesentery and report on the pathogenesis, biologic behavior, diagnosis and treatment of similar extra-ovarian tumors. We propose an updated classification of mesenteric cysts and cystic tumors.</p> <p>Conclusion</p> <p>Mucinous cystic neoplasms of the mesentery present almost exclusively in women and must be considered in the differential diagnosis of mesenteric tumors. Only full histological examination of a mucinous cystic neoplasm can exclude a borderline or malignant component. An updated classification of mesenteric cysts and cystic tumors is proposed.</p

Evaluation of Deltamethrin induced reproductive toxicity in male Swiss Albino mice

Objective: To assess the adverse effect of Deltamethrin (DM) (technical grade) on reproductive organs and fertility indices of male Swiss albino mice, Mus musculus. Methods: Forty male mice were divided into four experimental groups: control, vehicle control (peanut oil), high dose DM treated and low dose DM treated group. An oral dose of 3 mg/kg b.wt (low dose) and 6 mg/kg b.wt (high dose) of Deltamethrin was administered for a period of 45 days to male Swiss albino mice. Results: DM caused a significant reduction in body and organ weights, sperm count, sperm motility percent, sperm viability, serum testosterone level, sialic acid content of cauda epididymis and fructose level of seminal vesicle. DM-treated groups also showed a significant decline in testicular 3β and 17β Hydroxysteroid Dehydrogenase (HSD) activities. Histological examinations revealed significant alterations in the testes of dosed groups. Conclusion: Deltamethrin is a toxic pyrethroid pesticide that produced significant reproductive toxicity in treated male mice as revealed by the severely affected parameters and the altered gravimetric indices

Bone marrow in Hodgkin lymphoma and mimickers.

the chapter describes the features of bone marrow involvement by Hodgkin lymphom