Design and Construction of A 50kg Capacity Furnace

The design and development of a 50Kg charcoal fired crucible furnace for melting aluminium and its alloys are presented. Importance of Metal melting furnaces cannot be overemphasized in industrialized and under industrialized countries. A detailed designed analysis was conducted to determine the various component sizes of the crucible furnace so to pave way for its construction. Majority of the materials used for the furnace construction were obtained locally. The blower capacity was determined to be air to ratio of 400:1 and 0.05m3/min. The designed furnace of overall volumetric capacity of 0.57m3 accommodates a crucible pot which had a height and volume of 0.577m and 0.0155m3 respectively. The designed operating temperature of the furnace was 1200oC and maintained a heat transfer rate of 494.2W/m2 across the wall. The designed efficiency of the charcoal fired furnace was 59.35%. Keywords: Crucible, furnace, Charcoal, Volumetric capacity, Design, Efficiency DOI: 10.7176/ISDE/12-2-03 Publication date: April 30th 202

Attributions to Discrimination and Self-Esteem: The Role of Group Identification and Appraisals

This study tested the hypothesis that appraisals of discrimination (i.e. its perceived severity, global aspects, stability, and uncontrollability) mediate the relationship between attributions to discrimination and personal self-esteem. It also tested three models of how ethnic group identification is related to discrimination attributions, discrimination appraisals, and personal self-esteem. In a cross-sectional study of 160 Latino-American students, group identification was positively related to attributing ambiguous negative events to discrimination. Discrimination attributions were related to appraising discrimination as more global and severe. These latter appraisals, in turn, were related to lower self-esteem. No direct relationships were observed between self-esteem and either group identification or discrimination attributions. Results illustrate the importance of appraisals in understanding the relationship between perceived discrimination and self-esteem

About the dynamics and thermodynamics of trapped ions

This tutorial introduces the dynamics of charged particles in a radiofrequency trap in a very general manner to point out the differences between the dynamics in a quadrupole and in a multipole trap. When dense samples are trapped, the dynamics is modified by the Coulomb repulsion between ions. To take into account this repulsion, we propose to use a method, originally developed for particles in Penning trap, that model the ion cloud as a cold fluid. This method can not reproduce the organisation of cold clouds as crystals but it allows one to scale the size of large samples with the trapping parameters and the number of ions trapped, for different linear geometries of trap.Comment: accepted for publication in the "Modern Applications of Trapped Ions" special issu

Prospecting for an HIV Vaccine

Human immunodeficiency virus (HIV) sets several challenges for the development of a preventative HIV vaccine. Predictable, protective natural immunity against HIV does not occur and so unlike most other diseases for which vaccines exist, there are few guideposts from natural infection. Nonetheless, six vaccine efficacy trials have occurred. One in particular, the Thai trial called RV144, showed partial protective efficacy and potential ways ahead to a better vaccine approach. This coupled with other lessons from studies of acute infections as well as an increasingly complex knowledge of HIV-related vaccine immunology bring hope that a vaccine solution might be reached for this pervasive and deadly pandemic

The Effect of Patient Weight and Provider Training and Experience on Dosing of Rocuronium

Introduction. Maintenance dosing of neuromuscular blocking agents is complex and varies with patient, procedure, and clinical situation. With this in mind, we sought to identify factors impacting the maintenance dosing of neuromuscular blockers as a step toward identifying best practice with respect to minimizing residual neuromuscular blockade. Methods. Cases utilizing rocuronium from July 1, 2010, to June 30, 2014, at the sponsoring institution were analyzed. Using a mixed model to account for repeated measures, patients were analyzed by dose and weight category as defined by the World Health Organization (eight categories ranging from very severely underweight to very severely obese) as well as by the administering provider’s level of experience. Results. The study included 12,671 patients with a mean age of 49.7 (SD 16.7). Increasing weight category and higher levels of provider experience were associated with higher doses for rocuronium. There were no differences in initial dose or in frequency of maintenance dosing by weight category after controlling for case length. Discussion. The two dosing patterns identified, higher doses for overweight patients and higher doses administered by experienced providers, are modifiable factors that could enhance patient safety

Conceptual design study for heat exhaust management in the ARC fusion pilot plant

The ARC pilot plant conceptual design study has been extended beyond its initial scope [B. N. Sorbom et al., FED 100 (2015) 378] to explore options for managing ~525 MW of fusion power generated in a compact, high field (B_0 = 9.2 T) tokamak that is approximately the size of JET (R_0 = 3.3 m). Taking advantage of ARC's novel design - demountable high temperature superconductor toroidal field (TF) magnets, poloidal magnetic field coils located inside the TF, and vacuum vessel (VV) immersed in molten salt FLiBe blanket - this follow-on study has identified innovative and potentially robust power exhaust management solutions.Comment: Accepted by Fusion Engineering and Desig

Penning traps as a versatile tool for precise experiments in fundamental physics

This review article describes the trapping of charged particles. The main principles of electromagnetic confinement of various species from elementary particles to heavy atoms are briefly described. The preparation and manipulation with trapped single particles, as well as methods of frequency measurements, providing unprecedented precision, are discussed. Unique applications of Penning traps in fundamental physics are presented. Ultra-precise trap-measurements of masses and magnetic moments of elementary particles (electrons, positrons, protons and antiprotons) confirm CPT-conservation, and allow accurate determination of the fine-structure constant alpha and other fundamental constants. This together with the information on the unitarity of the quark-mixing matrix, derived from the trap-measurements of atomic masses, serves for assessment of the Standard Model of the physics world. Direct mass measurements of nuclides targeted to some advanced problems of astrophysics and nuclear physics are also presented

Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy

Background: Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients. Methods: We invited patients who had participated in clinical trials in which they received recent or long-term treatment with natalizumab for multiple sclerosis, Crohn's disease, or rheumatoid arthritis to participate. The clinical history, physical examination, brain magnetic resonance imaging (MRI), and testing of cerebrospinal fluid for JC virus DNA were used by an expert panel to evaluate patients for PML. We estimated the risk of PML in patients who completed at least a clinical examination for PML or had an MRI. Results: Of 3417 patients who had recently received natalizumab while participating in clinical trials, 3116 (91 percent) who were exposed to a mean of 17.9 monthly doses underwent evaluation for PML. Of these, 44 patients were referred to the expert panel because of clinical findings of possible PML, abnormalities on MRI, or a high plasma viral load of JC virus. No patient had detectable JC virus DNA in the cerebrospinal fluid. PML was ruled out in 43 of the 44 patients, but it could not be ruled out in one patient who had multiple sclerosis and progression of neurologic disease because data on cerebrospinal fluid testing and follow-up MRI were not available. Only the three previously reported cases of PML were confirmed (1.0 per 1000 treated patients; 95 percent confidence interval, 0.2 to 2.8 per 1000). Conclusions: A detailed review of possible cases of PML in patients exposed to natalizumab found no new cases and suggested a risk of PML of roughly 1 in 1000 patients treated with natalizumab for a mean of 17.9 months. The risk associated with longer treatment is not known