Significado do turismo de peregrinación para o desenvolvemento local. Caso das peregrinacións á Basílica Nacional da Nosa Señora da Pura e Limpa Concepción do Río Luján, provincia de Bos Aires, Arxentina

[Resumen] Entre las características culturales que contribuyeron a forjar el valor turístico de la actual ciudad de Luján de la Provincia de Buenos Aires, Argentina, descuella, en particular, la religiosa, factor que constituye un elemento clave de la concepción de cualquier estrategia de desarrollo local que se asuma. El significado de la virgen de Luján, Nuestra Señora de la Pura y Limpia Concepción del río Luján, su historia, prácticamente, hilvana el relato científicamente edificado acerca del asentamiento y de la sociedad, lujanenses, en una amalgama permanentemente renovada por el fenómeno singular, por la diversidad de sus expresiones, de las peregrinaciones a Virgen y a la Basílica Nacional Nuestra Señora de Luján.[Resumo] Entre as características culturais que contribuíron a forzar o valor turístico da actual cidade de Luján da provincia de Bos Aires, Arxentina, sobresae, en particular, a relixiosa, factor que constitúe un elemento clave da concepción de calquera estratexia de desenvolvemento local que se asuma. O significado da virxe de Luján, A Nosa Señora da Pura e Limpa concepción do río Luján, a súa historia, practicamente ganduxa o relato cientificamente edificado acerca do asentamento e da sociedade lujanenses, nunha amálgama permanentemente renovada polo fenómeno singular, pola diversidade das súas expresións, das peregrinacións á Virxe e á Basílica Nacional da Nosa Señora de Luján.[Abstract] This includes an analysis of the promotion of the Camino de Santiago over the last few decades, the context in which this was carried out, the parties involved in the process, the promotional strategies to attract tourists and travel agencies, sponsorship, and collaboration with the private sector, with the political institutions, with the media and with civil society. It also examines the communication activities carried out, the materials used with their identifying symbols (mascot, logotype, credentials), the changes of image under the Xacobeo brand, and the link between the communication carried out (image projected), the confirmed initial image and the a posteriori image perceived by visitors

Luján (provincia de Buenos Aires, Argentina): imagen y destino turístico. Contribución al análisis de una perspectiva el patrimonio territorial

XII Coloquio de Geografía del Turismo, Ocio y Recreación de la Asociación de Geógrafos Españoles. Colmenarejo (Madrid), del 17 al 19 de junio de 2010

Effect of Temperature and Pressure on Surface Tension of Polystyrene in Supercritical Carbon Dioxide

This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry B., 111, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/jp065851tThe surface tension of polymers in a supercritical fluid is one of the most important physicochemical parameters in many engineering processes, such as microcellular foaming where the surface tension between a polymer melt and a fluid is a principal factor in determining cell nucleation and growth. This paper presents experimental results of the surface tension of polystyrene in supercritical carbon dioxide, together with theoretical calculations for a corresponding system. The surface tension is determined by Axisymmetric Drop Shape Analysis-Profile (ADSA-P), where a high pressure and temperature cell is designed and constructed to facilitate the formation of a pendant drop of polystyrene melt. Self-consistent field theory (SCFT) calculations are applied to simulate the surface tension of a corresponding system, and good qualitative agreement with experiment is obtained. The physical mechanisms for three main experimental trends are explained using SCFT, and none of the explanations quantitatively depend on the configurational entropy of the polymer constituents. These calculations therefore rationalize the use of simple liquid models for the quantitative prediction of surface tensions of polymers. As pressure and temperature increase, the surface tension of polystyrene decreases. A linear relationship is found between surface tension and temperature, and between surface tension and pressure; the slope of surface tension change with temperature is dependent on pressure.Natural Sciences and Engineering Research Council of Canada (NSERC) Canadian Foundation for Innovation (CFI) Canada Research Chairs (CRC) Progra

FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis

Mutations in the SOD1 and TARDBP genes have been commonly identified in Amyotrophic Lateral Sclerosis (ALS). Recently, mutations in the Fused in sarcoma gene (FUS) were identified in familial (FALS) ALS cases and sporadic (SALS) patients. Similarly to TDP-43 (coded by TARDBP gene), FUS is an RNA binding protein. Using the zebrafish (Danio rerio), we examined the consequences of expressing human wild-type (WT) FUS and three ALS–related mutations, as well as their interactions with TARDBP and SOD1. Knockdown of zebrafish Fus yielded a motor phenotype that could be rescued upon co-expression of wild-type human FUS. In contrast, the two most frequent ALS–related FUS mutations, R521H and R521C, unlike S57Δ, failed to rescue the knockdown phenotype, indicating loss of function. The R521H mutation caused a toxic gain of function when expressed alone, similar to the phenotype observed upon knockdown of zebrafish Fus. This phenotype was not aggravated by co-expression of both mutant human TARDBP (G348C) and FUS (R521H) or by knockdown of both zebrafish Tardbp and Fus, consistent with a common pathogenic mechanism. We also observed that WT FUS rescued the Tardbp knockdown phenotype, but not vice versa, suggesting that TARDBP acts upstream of FUS in this pathway. In addition we observed that WT SOD1 failed to rescue the phenotype observed upon overexpression of mutant TARDBP or FUS or upon knockdown of Tardbp or Fus; similarly, WT TARDBP or FUS also failed to rescue the phenotype induced by mutant SOD1 (G93A). Finally, overexpression of mutant SOD1 exacerbated the motor phenotype caused by overexpression of mutant FUS. Together our results indicate that TARDBP and FUS act in a pathogenic pathway that is independent of SOD1