The Rise of Human Rights Education: Opportunities, Challenges, and Future Possibilities

Human rights education (HRE) has gained increasing support as a tool for promoting social responsibility and global respect for international human rights standards. Many schools and universities include HRE in their curricula in an attempt to foster a sense of global citizenship among students, yet educators still grapple with how to most effectively include human rights in undergraduate programs. In an attempt to provide resources and to promote effective HRE, this article examines the rise of human rights education and analyzes its potential for positive change. In particular, high impact learning practices (such as community partnerships and short-term study abroad trips) and service learning offer tools for effective HRE. The article also considers inherent challenges facing HRE educators, especially within higher education. It argues that the future of HRE requires critical consideration of core human rights values and practices that are often taken for granted. While growing support for HRE has built a solid foundation for undergraduate education, we must critically consider opportunities, challenges, and future possibilities for effective and widely-available human rights education

Facilitating student engagement: Social responsibility and freshmen learning communities

Human rights education is advanced as a method for promoting social responsibility, with an emphasis on promoting ideals of “global citizenship” among undergraduate students. At the same time, the practice of learning communities is widespread on college campuses for retaining freshmen and promoting student success. However, there is limited research on the effectiveness of combining these approaches. In response to this literature gap, this article first provides an overview of key concepts—social responsibility, human rights education, and learning communities—and outlines how these terms are currently understood within higher education. Second, the methods and initial findings of a longitudinal study within Webster University’s Social Engagement Learning Community focus on gauging and assessing human rights knowledge and social engagement. Initial findings suggest that most freshmen respondents lack basic human rights knowledge and an activist orientation, yet their empathy and perspective-taking abilities provide foundations for building awareness of human rights issues and social responsibility. Lastly, recommendations are outlined for addressing learning goals related to identity awareness, helping students step outside of their “comfort zones,” and promoting awareness and solutions

The structure of glucose-fructose oxidoreductase from Zymomonas mobilis: an osmoprotective periplasmic enzyme containing non-dissociable NADP

AbstractBackground The organism Zymomonas mobilis occurs naturally in sugar-rich environments. To protect the bacterium against osmotic shock, the periplasmic enzyme glucose-fructose oxidoreductase (GFOR) produces the compatible, solute sorbitol by reduction of fructose, coupled with the oxidation of glucose to gluconolactone. Hence, Z. mobilis can tolerate high concentrations of sugars and this property may be useful in the development of an efficient microbial process for ethanol production. Each enzyme subunit contains tightly associated NADP which is not released during the catalytic cycle.Results The structure of GFOR was determined by X-ray crystallography at 2.7 å resolution. Each subunit of the tetrameric enzyme comprises two domains, a classical dinucleotide-binding domain, and a C-terminal domain based on a predominantly antiparallel nine-stranded β sheet. In the tetramer, the subunits associate to form two extended 18-stranded β sheets, which pack against each other in a face to face fashion, creating an extensive interface at the core of the tetramer. An N-terminal arm from each subunit wraps around the dinucleotide-binding domain of an adjacent subunit, covering the adenine ring of NADP.Conclusions In GFOR, the NADP is found associated with a classical dinucleotide-binding domain in a conventional fashion. The NADP is effectively buried in the protein-subunit interior as a result of interactions with the N-terminal arm from an adjacent subunit in the tetramer, and with a short helix from the C-terminal domain of the protein. This accounts for NADP's inability to dissociate. The N-terminal arm may also contribute to stabilization of the tetramer. The enzyme has an unexpected structural similarity with the cytoplasmic enzyme glucose-6-phosphate dehydrogenase (G6PD). We hypothesize that both enzymes have diverged from a common ancestor. The mechanism of catalysis is still unclear, but we have identified a conserved structural motif (Glu–Lys–Pro) in the active site of GFOR and G6PD that may be important for catalysis

Statelessness as a Lack of Functioning Citizenship

Central to the issue of statelessness is the concept of ‘functioning citizenship’, which requires an active and mutually-beneficial relationship between the state and the individual. This relationship is essential for the protection and promotion of international human rights. In cases of both 'de facto' and 'de jure' statelessness, however, this robust form of political membership is limited or missing entirely. Expanding on Elizabeth F. Cohen’s concept of ‘semi-citizenship’, this article contends that membership exists along a spectrum and requires not only the granting of formal citizenship, but also attention to the functionality of that relationship. Government-sponsored identities will continue to be important prerequisites for rights protection within the modern ‘society of states’, but truly functioning citizenship requires us to expand our understandings of responsibility and membership. The international community must critically examine the ways that individuals are recognized as worthy of human rights

Visual phototransduction components in cephalopod chromatophores suggest dermal photoreception

Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of The Company of Biologists for personal use, not for redistribution. The definitive version was published in Journal of Experimental Biology 218 (2015): 1596-1602, doi: 10.1242/​jeb.117945.Cephalopod molluscs are renowned for their colorful and dynamic body patterns, produced by an assemblage of skin components that interact with light. These may include iridophores, leucophores, chromatophores, and (in some species) photophores. Here, we present molecular evidence suggesting that cephalopod chromatophores, small dermal pigmentary organs that reflect various colors of light, are photosensitive. RT-PCR revealed the presence of transcripts encoding rhodopsin and retinochrome within the retinas and skin of the squid Doryteuthis pealeii, and the cuttlefish Sepia officinalis and Sepia latimanus. In D. pealeii, Gqα and squid TRP channel transcripts were present in the retina and in all dermal samples. Rhodopsin, retinochrome, and Gqα transcripts were also found in RNA extracts from dissociated chromatophores isolated from D. pealeii dermal tissues. In D. pealeii, immunohistochemical staining labeled rhodopsin, retinochrome, and Gqα proteins in several chromatophore components, including pigment cell membranes, radial muscle fibers, and sheath cells. This is the first evidence that cephalopod dermal tissues, and specifically chromatophores, may possess the requisite combination of molecules required to respond to light.This research was supported by the Office of Naval Research Basic Research Challenge [grant number N00014-10-0989] via a subcontract to T.W.C. and R.T.H.2016-05-1

Symmetry classification of third-order nonlinear evolution equations. Part I: Semi-simple algebras

We give a complete point-symmetry classification of all third-order evolution equations of the form $u_t=F(t,x,u,u_x, u_{xx})u_{xxx}+G(t,x,u,u_x, u_{xx})$ which admit semi-simple symmetry algebras and extensions of these semi-simple Lie algebras by solvable Lie algebras. The methods we employ are extensions and refinements of previous techniques which have been used in such classifications.Comment: 53 page

Responding to the increased genetic risk associated with customary consanguineous marriage among minority ethnic populations: lessons from local innovations in England.

Populations practising customary consanguineous marriage have a higher incidence of autosomal recessive genetic disorders than those in which reproductive partners are usually unrelated. In the absence of any national-level response, English service developments to address the additional needs of families living with or at risk of such disorders have been locally led. These interventions remain in their infancy here, as elsewhere in Europe, and important questions remain regarding how appropriate, effective and sustainable responses can be operationalised in practice. This formative service review employed four local case studies together with wider consultation exercises over a 4-year period (2011-2015) to document recent responses to this area of need, issues arising and lessons to inform future work. Service components included the following: enhancements to genetic services to provide family-centred, culturally competent approaches to counselling and testing; community genetic literacy approaches; and capacity development among health professionals. Local approaches were, however, very varied in their detail, scope, level of investment and longevity. The provisions of culturally competent genetic counselling services and community-level genetic literacy interventions were generally well received by those who accessed them. Coordinated action across all service components appeared important for an effective service, but healthcare professionals, particularly general practitioners, were often difficult to engage in this agenda. An evaluative culture and engagement in a wider community of practice had supported service development across sites. However, sustaining investment was challenging, particularly where new services were not well integrated into core provision and where commissioning was driven by expectations of short-term reductions in infant mortality and disability

Detection and classification of Bacteria using Raman Spectroscopy Combined with Multivariate Analysis

Vibrational spectroscopic techniques have advantages over conventional microbiological approaches towards identification & detection of pathogens. Since unique spectral fingerprint is obtained, one can identify very closely related bacteria using such methods. In this study Raman microspectroscopy in combination with chemometric method has been used to classify four strains of E. coli (two pathogenic & two non-pathogenic). Different multivariate approaches such as hierarchical cluster analysis, principal component analysis & linear discriminant analysis were explored to obtain efficient classification of the Raman signals obtained from the four strains of E.coli. It was observed that multivariate analysis was able to classify the bacteria at strain level. Linear discrimination analysis using PC scores (PC-LDA) was found to give very good result with as high as 100% accuracy. This hybrid technique (Raman spectroscopy & multivariate analysis) has tremendous potential to be developed as a tool for bacterial identification.