8 research outputs found

    Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis

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    This study reveals novel roles for the focal adhesion proteins paxillin and Hic-5 in regulating breast cancer invasion strategies and metastasis. Depletion of paxillin promotes a hypermesenchymal phenotype while dysregulating 3D adhesion dynamics. In contrast, RNAi of Hic-5 induces a hyperamoeboid phenotype with dysregulated RhoA/pMLC signaling

    Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression

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    Genome-Wide Activities of RNA Binding Proteins That Regulate Cellular Changes in the Epithelial to Mesenchymal Transition (EMT)

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