8 research outputs found
Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK
No full textApoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK
No full textLoss of anchorage primarily induces non-apoptotic cell death in a human mammary epithelial cell line under atypical focal adhesion kinase signaling
No full textLIM kinase regulation of cytoskeletal dynamics is required for salivary gland branching morphogenesis
No full textDistinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis
No full textThis study reveals novel roles for the focal adhesion proteins paxillin and Hic-5 in regulating breast cancer invasion strategies and metastasis. Depletion of paxillin promotes a hypermesenchymal phenotype while dysregulating 3D adhesion dynamics. In contrast, RNAi of Hic-5 induces a hyperamoeboid phenotype with dysregulated RhoA/pMLC signaling
Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression
No full text
