33 research outputs found
Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary âVoxToxâ research programme
The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.JES was supported by Cancer Research UK through the Cambridge Cancer Centre. NGB, ASP and MG are supported by the National Institute of Health Research Cambridge Biomedical Research Centre. KH, MR AMB, EW and SJB were supported by the VoxTox Research Programme, funded by Cancer Research UK. DJN is supported by Addenbrookeâs Charitable Trust and Cancer Research UK through the Cambridge Cancer Centre. FMB was supported by the Science and Technology Facilities Council. MPDS was part supported by the VoxTox Research Programme, funded by Cancer Research UK. RJ was part supported by the VoxTox Research Programme, funded by Cancer Research UK. LS is supported by the Armstrong Trust. XC was supported by the Isaac Newton Trust. CBS acknowledges support from the EPSRC Centre for Mathematical and Statistical Analysis of Multimodal Clinical Imaging, the Leverhulme Trust, the EU-RISE project CHiPS and the Cantab Capital Institute for the Mathematics of Information. NT was supported by a Gates-Cambridge Scholarship, funded by the Bill and Melinda Gates Foundation, PLY and SYKS by the Singapore Government
Unique patterns of transcript and miRNA expression in the South American strong voltage electric eel (Electrophorus electricus)
The role of 90Y-radioembolization in downstaging primary and secondary hepatic malignancies: a systematic review
A comparison of repeat cross-sectional and longitudinal results from the COMPASS study: design considerations for analysing surveillance data over time
Competitive swarm optimizer with mutated agents for finding optimal designs for nonlinear regression models with multiple interacting factors
Synthesis and Structural Properties of Niobium Pentoxide Powders: A Comparative Study of the Growth Process
Powders Nb2 O5 were prepared by two different synthesis method, Sol-Gel and polymeric precursors (Pechini). In the Pechini method before adding the citric acid in the process, four different solutions were used to get the samples. For Sol-gel method, two different processes were also used in obtaining powders. The precursor was completely solubilized in ethanol and then hydrolyzed with ammonia and water. The calcination of the samples was between 500 and 750°C. The resulting powders were characterized by Scanning Electron Microscopy (SEM), Brunauer, Emmett and Teller (BET) surface area measurements, UV-visible and Raman spectroscopy. The formation of T−Nb2 O5 orthorhombic took place upon calcination at 7500C. Crystallite sizes were determined using the Scherrer method which resulted in an uniformed size of about 25 − 65nm. Ultraviolet-Visible diffuse reflectance spectroscopy indicated a variation in the optical band gap values (3.32-3.40 eV) in crystal growth process. The Raman vibrational modes indicate the presence of the orthorhombic phase of the material