Space station attitude disturbance arising from internal motions

A source of space station attitude disturbances is identified. The attitude disturbance is driven by internal space station motions and is a direct result of conservation of angular momentum. Three examples are used to illustrate the effect: a planar three link system, a rigid carrier body with two moveable masses, and a nonplanar five link system. Simulation results are given to show the magnitude of the attitude change in each example. Factors which accentuate or attenuate this disturbance effect are discussed

The effect of an hypoxic cell sensitizer on tumour growth delay and cell survival. Implications for cell survival in situ and in vitro.

A comparison has been made of the effects of the 2-nitroimidazole Ro-07-0582 on tumour growth delay after irradiation and tumour cell survival in vitro after irradiation in vivo. This compound has previously been shown to be a specific sensitizer of hypoxic cells. A dose of 1 mg/g body weight gave an enhancement ratio of 2-2 for both growth delay and cell survival in a system where high pressure oxygen has been shown to have no effect. However, while the hypoxic fraction in the tumour was estimated to be less then 10% from the growth delay curves, the survival curves gave a value in excess of 50%. This discrepancy probably reflects differences in the response of cells left in situ or removed and assayed in vitro

Cytotoxicity of adriamycin to tumour cells in vivo and in vitro.

Two mouse sarcomas have been used to assess the sensitivity to Adriamycin of tumour cells in vivo and in vitro. Both tumours were tissue-culture adapted so that cell survival could be assayed in vitro after treatment either in vivo or in vitro. For both tumours (WHFIB and CBSAF) cells were highly sensitive when treated in vitro yet very resistant to treatment in vivo, whether assayed by cell survival or regrowth delay. Cells from both tumours treated in vitro with Adriamycin immediately after excision were slightly more resistant than the cells maintained in vitro. However, this was not adequate to explain the marked discrepancy between in vivo resistance and in vitro sensitivity. The discrepancy was not due to a failure of drug delivery. Phase of cell growth was the factor was most significantly affecting chemosensitivity in vitro, plateau-phase cells being much more resistant than log-phase cells. Hypoxia was also an important factor leading to reduced chemosensitivity. Tumour diameter, in the range 2-8 mm, did not appear to be important

Rossby wave instability does not require sharp resistivity gradients

Context. Rossby wave instability (RWI) at dead zone boundaries may play an important role in planet formation. Viscous hydrodynamics results suggest RWI is excited only when the viscosity changes over a radial distance less than two density scale heights. However in the disks around Solar-mass T Tauri stars, it is not viscosity but magnetic forces that provide the accretion stress beyond about 10 AU, where surface densities are low enough so stellar X-rays and interstellar cosmic rays can penetrate. Aims. We explore the conditions for RWI in the smooth transition with increasing distance, from resistive and magnetically-dead to conducting and magnetically-active. Methods. We perform 3D unstratified MHD simulations with the Pencil code, using static resistivity profiles. Results. We find that in MHD, contrary to viscous models, the RWI is triggered even with a gradual change in resistivity extending from 10 to 40 AU (i.e., spanning 15 scale heights for aspect ratio 0.1). This is because magneto-rotational turbulence sets in abruptly when the resistivity reaches a threshold level. At higher resistivities the longest unstable wavelength is quenched, resulting in a sharp decline of the Maxwell stress towards the star. The sharp gradient in the magnetic forces leads to a localized density bump, that is in turn Rossby wave unstable. Conclusions. Even weak gradients in the resistivity can lead to sharp transitions in the Maxwell stress. As a result the RWI is more easily activated in the outer disk than previously thought. Rossby vortices at the outer dead zone boundary thus could underlie the dust asymmetries seen in the outer reaches of transition disks

Advancing the digital and computational capabilities of healthcare providers: A qualitative study of a hospital organisation in the NHS

Objective: Healthcare systems require transformation to meet societal challenges and projected health demands. Digital and computational tools and approaches are fundamental to this transformation, and hospitals have a key role to play in their development and implementation. This paper reports on a study with the objective of exploring the challenges encountered by hospital leaders and innovators as they implement a strategy to become a data-driven hospital organisation. In doing so, this paper provides guidance to future leaders and innovators seeking to build computational and digital capabilities in complex clinical settings. Methods: Interviews were undertaken with 42 participants associated with a large public hospital organisation within England's National Health Service. Using the concept of institutional readiness as an analytical framework, the paper explores participants’ perspectives on the organisation's capacity to support the development of, and benefit from, digital and computational approaches. Results: Participants’ accounts reveal a range of specific institutional readiness criteria relating to organisational vision, technical capability, organisational agility, and talent and skills that, when met, enhance the organisations’ capacity to support the development and implementation of digital and computational tools. Participant accounts also reveal challenges relating to these criteria, such as unrealistic expectations and the necessary prioritisation of clinical work in resource-constrained settings. Conclusions: The paper identifies a general set of institutional readiness criteria that can guide future hospital leaders and innovators aiming to improve their organisation's digital and computational capability. The paper also illustrates the challenges of pursuing digital and computational innovation in resource-constrained hospital environments

The effect of radiosensitizers on the pharmacokinetics of melphalan and cyclophosphamide in the mouse.

Misonidazole (MISO) has been shown to affect the pharmacokinetics of both cyclophosphamide (CY) and melphalan (MEL) in WHT mice resulting in increased plasma levels of the cytotoxic drugs. The effect is not solely due to the reduction in body temperature observed with large single doses of MISO, as a change in MEL pharmacokinetics was still observed when the mice were maintained at 37 degrees C. Inhibition of cytotoxic drug metabolism may also be a possible mechanism. Such a pharmacokinetic effect could account for part of the potentiation of MEL and CY action observed in tumours with large single doses of MISO. However, a chronic low dosing schedule of MISO did not affect the plasma half-life of either cytotoxic drug, although a significant potentiation of each drug in combination with a chronic MISO dose has been obtained in some tumours. These results suggest that potentiation of chemotherapeutic drug action by MISO in the clinical situation is unlikely to be due to changes in drug pharmacokinetics