1,739 research outputs found
E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I
p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified. Further, the p62-mediated protein aggregation's effect on autophagy is unclear. We systemically analyzed the interactions of p62 with all known Atg proteins involved in LC3 lipidation. We find that p62 does not interact with LC3 at the stages when it is being processed by Atg4B or when it is complexed or conjugated with Atg3. p62 does interact with LC3-I and LC3-I:Atg7 complex and is preferentially recruited by LC3-II species under autophagic stimulation. Given that Atg4B, Atg3 and LC3-Atg3 are indispensable for LC3-II conversion, our study reveals a protective mechanism for Atg4B, Atg3 and LC3-Atg3 conjugate from being inappropriately sequestered into p62 aggregates. Our findings imply that p62 could potentially impair autophagy by negatively affecting LC3 lipidation and contribute to the development of protein aggregate diseases. © 2013 Gao et al
Chiral symmetry breaking and stability of strangelets
We discuss the stability of strangelets by considering dynamical chiral
symmetry breaking and confinement. We use a
symmetric Nambu--Jona-Lasinio model for chiral symmetry breaking supplemented
by a boundary condition for confinement. It is shown that strangelets with
baryon number can stably exist. For the observables, we
obtain the masses and the charge-to-baryon number ratios of the strangelets.
These quantities are compared with the observed data of the exotic particles.Comment: 10 pages, 9 figures, submitted to Physical Review
Method of extending hyperfine coherence times in Pr^3+:Y_2SiO_5
In this letter we present a method for increasing the coherence time of
praseodymium hyperfine ground state transitions in Pr^3+:Y_2SiO_5 by the
application of a specific external magnetic field. The magnitude and angle of
the external field is applied such that the Zeeman splitting of a hyperfine
transition is at a critical point in three dimensions, making the first order
Zeeman shift vanishingly small for the transition. This reduces the influence
of the magnetic interactions between the praseodymium ions and the spins in the
host lattice on the transition frequency. Using this method a phase memory time
of 82ms was observed, a value two orders of magnitude greater than previously
reported. It is shown that the residual dephasing is amenable quantum error
correction
Theory of the beta-type Organic Superconductivity under Uniaxial Compression
We study theoretically the shift of the superconducting transition
temperature (Tc) under uniaxial compression in beta-type organic
superconductors, beta-(BEDT-TTF)2I3 and beta-(BDA-TTP)2X[X=SbF6,AsF6], in order
to clarify the electron correlation, the spin frustration and the effect of
dimerization. The transfer integrals are calculated by the extended Huckel
method assuming the uniaxial strain and the superconducting state mediated by
the spin fluctuation is solved using Eliashberg's equation with the
fluctuation-exchange approximation. The calculation is carried out on both the
dimerized (one-band) and nondimerized (two-band) Hubbard models. We have found
that (i) the behavior of Tc in beta-(BEDT-TTF)2I3 with a stronger dimerization
is well reproduced by the dimer model, while that in weakly dimerized
beta-BDA-TTP salts is rather well reproduced by the two-band model, and (ii)
the competition between the spin frustration and the effect induced by the
fluctuation is important in these materials, which causes nonmonotonic shift of
Tc against uniaxial compression.Comment: 18 pages, 16 figures, 2 tabl
Spin-density-wave transition of (TMTSF)PF at high magnetic fields
The transverse magnetoresistance of the Bechgaard salt (TMTSF)PF has
been measured for various pressures, with the field up to 24 T parallel to the
lowest conductivity direction c. A quadratic behavior is observed in
the magnetic field dependence of the spin-density-wave (SDW) transition
temperature . With increasing pressure,
decreases and the coefficient of the quadratic term increases. These results
are consistent with the prediction of the mean-field theory based on the
nesting of the quasi one-dimensional Fermi surface. Using a mean field theory,
for the perfect nesting case is estimated as about 16 K. This
means that even at ambient pressure where is 12 K, the SDW
phase of (TMTSF)PF is substantially suppressed by the
two-dimensionality of the system.Comment: 11pages,6figures(EPS), accepted for publication in PR
First-Principles Study on Peierls Instability in Infinite Single-Row Al Wires
We present the relation between the atomic and spin-electronic structures of
infinite single-row atomic wires made of Al atoms during their elongation using
first-principles molecular-dynamics simulations. Our study reveals that the
Peierls transition indeed occurs in the wire with magnetic ordering: it
ruptures to form a trimerized structure with antiferromagnetic ordering and
changes from a conductor to an insulator just before forming a linear wire of
equally-spaced atoms. The formation of the trimerized wire is discussed in
terms of the behavior of the -symmetry bands of the Al wire.Comment: 10 pages, 4 figure
Two-step contribution to the spin-longitudinal and spin-transverse cross sections of the quasielastic (p,n) reactions
The two-step contribution to the spin-longitudinal and the spin-transverse
cross sections of ^{12}C,^{40}Ca(p,n) reactions at 494 MeV and 346 MeV is
calculated. We use a plane-wave approximation and evaluate the relative
contributions from the one-step and the two-step processes. We found that the
ratios of the two-step to the one-step processes are larger in the
spin-transverse cross sections than in the spin-longitudinal ones. Combining
these results with the distorted-wave impulse approximation (DWIA) results we
obtained considerable two-step contributions to the spin-longitudinal and the
spin-transverse cross sections. The two-step processes are important in
accounting for the underestimation of the DWIA results for the
spin-longitudinal and the spin-transverse cross sections.Comment: LaTeX 11 pages, 10 figure
Measurement of ICRF waves in the GAMMA10 tandem mirror using reflectometers
科研費報告書収録論文(課題番号:07458088・基盤研究(B)(2)・H7~H8/研究代表者:犬竹, 正明/マイクロ波反射計とプローブ計測による密度および磁場揺動径方向分布の比較
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