357 research outputs found
Magnetization precession due to a spin polarized current in a thin nanoelement: numerical simulation study
In this paper a detailed numerical study (in frames of the Slonczewski
formalism) of magnetization oscillations driven by a spin-polarized current
through a thin elliptical nanoelement is presented. We show that a
sophisticated micromagnetic model, where a polycrystalline structure of a
nanoelement is taken into account, can explain qualitatively all most important
features of the magnetization oscillation spectra recently observed
experimentally (S.I. Kiselev et al., Nature, vol. 425, p. 380 (2003), namely:
existence of several equidistant spectral bands, sharp onset and abrupt
disappearance of magnetization oscillations with increasing current, absence of
the out-of-plane regime predicted by a macrospin model and the relation between
frequencies of so called small-angle and quasichaotic oscillations. However, a
quantitative agreement with experimental results (especially concerning the
frequency of quasichaotic oscillations) could not be achieved in the region of
reasonable parameter values, indicating that further model refinement is
necessary for a complete understanding of the spin-driven magnetization
precession even in this relatively simple experimental situation.Comment: Submitted to Phys. Rev. B; In this revised version figure positions
on the page have been changed to ensure correct placements of the figure
caption
The Projective Line Over the Finite Quotient Ring GF(2)[]/ and Quantum Entanglement I. Theoretical Background
The paper deals with the projective line over the finite factor ring
GF(2)[]/. The line is endowed with 18
points, spanning the neighbourhoods of three pairwise distant points. As
is not a local ring, the neighbour (or parallel) relation is
not an equivalence relation so that the sets of neighbour points to two distant
points overlap. There are nine neighbour points to any point of the line,
forming three disjoint families under the reduction modulo either of two
maximal ideals of the ring. Two of the families contain four points each and
they swap their roles when switching from one ideal to the other; the points of
the one family merge with (the image of) the point in question, while the
points of the other family go in pairs into the remaining two points of the
associated ordinary projective line of order two. The single point of the
remaining family is sent to the reference point under both the mappings and its
existence stems from a non-trivial character of the Jacobson radical, , of the ring. The factor ring is isomorphic to GF(2)
GF(2). The projective line over features nine
points, each of them being surrounded by four neighbour and the same number of
distant points, and any two distant points share two neighbours. These
remarkable ring geometries are surmised to be of relevance for modelling
entangled qubit states, to be discussed in detail in Part II of the paper.Comment: 8 pages, 2 figure
Structure peculiarities of cementite and their influence on the magnetic characteristics
The iron carbide is studied by the first-principle density functional
theory. It is shown that the crystal structure with the carbon disposition in a
prismatic environment has the lowest total energy and the highest energy of
magnetic anisotropy as compared to the structure with carbon in an octahedron
environment. This fact explains the behavior of the coercive force upon
annealing of the plastically deformed samples. The appearance of carbon atoms
in the octahedron environment can be revealed by Mossbauer experiment.Comment: 10 pages, 3 figures, 3 tables. submitted to Phys.Rev.
Inequality and Macroeconomic Factors: A Time-Series Analysis for a Set of OECD Countries
Reduced diversity and increased virulence-gene carriage in intestinal enterobacteria of coeliac children
<p>Abstract</p> <p>Background</p> <p>Coeliac disease is an immune-mediated enteropathology triggered by the ingestion of cereal gluten proteins. This disorder is associated with imbalances in the composition of the gut microbiota that could be involved in its pathogenesis. The aim of the present study was to determine whether intestinal <it>Enterobacteriaceae </it>populations of active and non-active coeliac patients and healthy children differ in diversity and virulence-gene carriage, so as to establish a possible link between the pathogenic potential of enterobacteria and the disease.</p> <p>Methods</p> <p><it>Enterobacteriaceae </it>clones were isolated on VRBD agar from faecal samples of 31 subjects (10 active coeliac patients, 10 symptom-free coeliac patients and 11 healthy controls) and identified at species level by the API 20E system. <it>Escherichia coli </it>clones were classified into four phylogenetic groups A, B1, B2 and D and the prevalence of eight virulence-associated genes (type-1 fimbriae [<it>fimA</it>], P fimbriae [<it>papC</it>], S fimbriae [<it>sfaD/E</it>], Dr haemagglutinin [<it>draA</it>], haemolysin [<it>hlyA</it>], capsule K1 [<it>neuB</it>], capsule K5 [<it>KfiC</it>] and aerobactin [<it>iutA</it>]) was determined by multiplex PCR.</p> <p>Results</p> <p>A total of 155 <it>Enterobacteriaceae </it>clones were isolated. Non-<it>E. coli </it>clones were more commonly isolated in healthy children than in coeliac patients. The four phylogenetic <it>E. coli </it>groups were equally distributed in healthy children, while in both coeliac patients most commensal isolates belonged to group A. Within the virulent groups, B2 was the most prevalent in active coeliac disease children, while D was the most prevalent in non-active coeliac patients. <it>E coli </it>clones of the virulent phylogenetic groups (B2+D) from active and non-active coeliac patients carried a higher number of virulence genes than those from healthy individuals. Prevalence of P fimbriae (<it>papC</it>), capsule K5 (<it>sfaD/E</it>) and haemolysin (<it>hlyA</it>) genes was higher in <it>E. coli </it>isolated from active and non-active coeliac children than in those from control subjects.</p> <p>Conclusion</p> <p>This study has demonstrated that virulence features of the enteric microbiota are linked to coeliac disease.</p
Thermal induced structural and magnetic transformations in Fe_{73.5βx}Ce_{x=0,3,5,7}Si_{13.5}B_9Nb_3Cu_1 amorphous alloy
Structural and magnetic properties of amorphous and partly crystallized Fe_{73.5βx}Ce_{x=0,3,5,7}Si_{13.5}B_9Nb_3Cu_1 alloys, were analysed in the temperature ranging from RT to 800 Β°C with scanning calorimetry and magnetometry. The Fe(Si) and Fe(B) structures were identified and characterised with set of crystallization temperatures and activation energies. Also, Curie temperatures for amorphous and for crystalline structures were determined and analysed as functions of Ce content
Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity
BACKGROUND: There is a large body of evidence which suggests that bile acids increase the risk of colon cancer and act as tumor promoters, however, the mechanism(s) of bile acids mediated tumorigenesis is not clear. Previously we showed that deoxycholic acid (DCA), a tumorogenic bile acid, and ursodeoxycholic acid (UDCA), a putative chemopreventive agent, exhibited distinct biological effects, yet appeared to act on some of the same signaling molecules. The present study was carried out to determine whether there is overlap in signaling pathways activated by tumorogenic bile acid DCA and chemopreventive bile acid UDCA. METHODS: To determine whether there was an overlap in activation of signaling pathways by DCA and UDCA, we mutagenized HCT116 cells and then isolated cell lines resistant to UDCA induced growth arrest. These lines were then tested for their response to DCA induced apoptosis. RESULTS: We found that a majority of the cell lines resistant to UDCA-induced growth arrest were also resistant to DCA-induced apoptosis, implying an overlap in DCA and UDCA mediated signaling. Moreover, the cell lines which were the most resistant to DCA-induced apoptosis also exhibited a greater capacity for anchorage independent growth. CONCLUSION: We conclude that UDCA and DCA have overlapping signaling activities and that disregulation of these pathways can lead to a more advanced neoplastic phenotype
Impaired Spleen Formation Perturbs Morphogenesis of the Gastric Lobe of the Pancreas
Despite the extensive use of the mouse as a model for studies of pancreas development and disease, the development of the gastric pancreatic lobe has been largely overlooked. In this study we use optical projection tomography to provide a detailed three-dimensional and quantitative description of pancreatic growth dynamics in the mouse. Hereby, we describe the epithelial and mesenchymal events leading to the formation of the gastric lobe of the pancreas. We show that this structure forms by perpendicular growth from the dorsal pancreatic epithelium into a distinct lateral domain of the dorsal pancreatic mesenchyme. Our data support a role for spleen organogenesis in the establishment of this mesenchymal domain and in mice displaying perturbed spleen development, including Dh +/β, Bapx1β/β and Sox11β/β, gastric lobe development is disturbed. We further show that the expression profile of markers for multipotent progenitors is delayed in the gastric lobe as compared to the splenic and duodenal pancreatic lobes. Altogether, this study provides new information regarding the developmental dynamics underlying the formation of the gastric lobe of the pancreas and recognizes lobular heterogeneities regarding the time course of pancreatic cellular differentiation. Collectively, these data are likely to constitute important elements in future interpretations of the developing and/or diseased pancreas
Role of Intraspecies Recombination in the Spread of Pathogenicity Islands within the Escherichia coli Species
Horizontal gene transfer is a key step in the evolution of bacterial pathogens. Besides phages and plasmids, pathogenicity islands (PAIs) are subjected to horizontal transfer. The transfer mechanisms of PAIs within a certain bacterial species or between different species are still not well understood. This study is focused on the High-Pathogenicity Island (HPI), which is a PAI widely spread among extraintestinal pathogenic Escherichia coli and serves as a model for horizontal transfer of PAIs in general. We applied a phylogenetic approach using multilocus sequence typing on HPI-positive and -negative natural E. coli isolates representative of the species diversity to infer the mechanism of horizontal HPI transfer within the E. coli species. In each strain, the partial nucleotide sequences of 6 HPIβencoded genes and 6 housekeeping genes of the genomic backbone, as well as DNA fragments immediately upstream and downstream of the HPI were compared. This revealed that the HPI is not solely vertically transmitted, but that recombination of large DNA fragments beyond the HPI plays a major role in the spread of the HPI within E. coli species. In support of the results of the phylogenetic analyses, we experimentally demonstrated that HPI can be transferred between different E. coli strains by F-plasmid mediated mobilization. Sequencing of the chromosomal DNA regions immediately upstream and downstream of the HPI in the recipient strain indicated that the HPI was transferred and integrated together with HPIβflanking DNA regions of the donor strain. The results of this study demonstrate for the first time that conjugative transfer and homologous DNA recombination play a major role in horizontal transfer of a pathogenicity island within the species E. coli
- β¦