CMS search plans and sensitivity to new physics with dijets

CMS will use dijets to search for physics beyond the standard model during early LHC running. The inclusive jet cross section as a function of jet transverse momentum, with 10 inverse picobarns of integrated luminosity, is sensitive to contact interactions beyond the reach of the Tevatron. The dijet mass distribution will be used to search for dijet resonances coming from new particles, for example an excited quark. Additional sensitivity to the existence of contact interactions or dijet resonances can be obtained by comparing dijet rates in two distinct pseudorapidity regions.Comment: 10 pages, 4 figures, accepted for publication in J. Phys. G: Nucl. Part. Phy

Gold and Silver Extraction from Leach Solutions

There has been carried out an investigation on the extraction of gold and silver from thiosulfate solutions: standard test and technological solutions of chemical and electrochemical leaching. The influence of related metals on the process of extracting gold from solution was studied. There has been conducted a comparative study of the IR spectra of solutions after the sorption of gold, silver and related metals

Sentinel Lymph Node Biopsy in Pure DCIS: Is It Necessary?

Introduction. Sentinel lymph node biopsy (SLNB) in patients with pure ductal carcinoma in situ (DCIS) has been a matter of debate due to very low rate of axillary metastases. We therefore aimed to identify factors in a single institutional series to select patients who may benefit from SLNB. Material and Methods. Patients, diagnosed with pure DCIS (n = 63) between July 2000 and March 2011, were reviewed. All the sentinel lymph nodes were examined by serial sectioning (50 μm) of the entire lymph node and H&E staining, and by cytokeratin immunostaining in suspicious cases. Results. Median age was 51 (range, 30–79). Of 63 patients, 40 cases (63.5%) with pure DCIS underwent SLN, and 2 of them had a positive SLN (5%). In both 2 cases with SLN metastases, only one sentinel lymph node was involved with tumor cells. Patients who underwent SLNB were more likely to have a tumor size >30 mm or DCIS with intermediate and high nuclear grade or a mastectomy in univariate and multivariate analyses. Conclusion. In our series, we found a slightly higher rate of SLNB positivity in patients with pure DCIS than the large series reported elsewhere. This may either be due to the meticulous examination of SLNs by serial sectioning technique or due to our patient selection criteria or both

Androgen receptor mutations in prostate cancer

We analyzed the frequency and relevance of mutations in the coding region of the androgen receptor (AR) in genomic DNA extracted from 137 specimens of prostate cancer. The specimens were obtained from the primary tumors of patients affected by stage B disease [15 nonmicrodissected (group 1A) and 84 microdissected (group 1B)] and from the metastatic deposits of individuals with stage D1 disease [8 nonmicrodissected (group 2A) and 30 microdissected (group 2B)] who had not undergone androgen ablation therapy. The study was conducted by PCR-single strand conformational polymorphism (SSCP) analysis of exons 2-8 in the four groups and direct sequence analysis of exon 1 in group 1B. As positive and negative controls, we used genomic DNA extracted from genital skin fibroblasts of patients affected by various forms of androgen resistance with known mutations in the AR. To control for genetic instability, PCR-SSCP analysis of exon 2 of the human progesterone receptor was carried out on each specimen. The overall number of mutations detected was 11 (8%). No mutations were detected in any of the 99 patients with stage B disease. Eleven mutations were detected in exons 2-8 in 8 of the 38 patients with stage D1 disease (all in group 2B). Simultaneous analysis of exon 2 of the progesterone receptor was carried out, and no SSCP changes were identified. These data suggest that AR mutations are rare and presumably do not play a role in the initial phase of prostatic carcinogenesis. The presence of a significant number of AR mutations in metastatic disease indicates that mutations of this molecule may play a role in the most advanced phases of the natural history of this disease, either by facilitating growth or acquisition of the metastatic phenotype

Type‐I interferons suppress microglial production of the lymphoid chemokine, CXCL13

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108063/1/glia22692.pd

Early growth performances of various seed sources of black (Prunus serotina Erhr.) and wild cherry (Prunus avium L.) seedlings on low and high elevation sites in the western Black Sea Region of Turkey

The growth performances of one-year old seedlings of various black cherry (BC) and wild cherry (WC) seed sources (SSs) that were planted on low elevation sites (LES) and high elevation sites (HES) in the western Black Sea Region (BSR) of Turkey were assessed one and five years after planting (YAP). Significance between and within-species variations were found for seedling growth. On species basis, WC was superior to BC for seedling groundline diameter and height growth for the low elevation sites(LES) of one and five years after planting (YAP), whereas no substantial survival and growth differences were found between the species for the high elevation sites (HES) of five YAP. Generally, seedlings averaged a greater survival on the LES, when compared with those on the HES. Local WC SSs (Tefen, Yayla and Dirgine) demonstrated an enhanced seedling survival and growth on LES than the other SSs. Unlike the LES results, a collection of BC (Michigan 1 and Ukraine) and WC SSs (Dirgine, Germany, and Tefen) displayed the best seedling growth over five years. The HES seedlings frequently experienced diebacks and forking due to heavy snow fall and wildlife browsing. Selection of the local WC SSs was vital for the LES. However, BC SSs may present a potential for planting on the HES with harsher environmental conditions.Keywords: Black cherry, provenance test, seedling growth and survival, wild cherry