Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both passively and/or actively. Polylactide-co-glycolide (PLGA), a biodegradable polyester approved for human use, has been used extensively. Here we report on recent developments concerning PLGA nanoparticles prepared for cancer treatment. We review the methods used for the preparation and characterization of PLGA nanoparticles and their applications in the delivery of a number of active agents. Increasing experience in the field of preparation, characterization, and in vivo application of PLGA nanoparticles has provided the necessary momentum for promising future use of these agents in cancer treatment, with higher efficacy and fewer side effects

Green chemistry and coronavirus

The novel coronavirus pandemic has rapidly spread around the world since December 2019. Various techniques have been applied in identification of SARS-CoV-2 or COVID-19 infection including computed tomography imaging, whole genome sequencing, and molecular methods such as reverse transcription polymerase chain reaction (RT-PCR). This review article discusses the diagnostic methods currently being deployed for the SARS-CoV-2 identification including optical biosensors and point-of-care diagnostics that are on the horizon. These innovative technologies may provide a more accurate, sensitive and rapid diagnosis of SARS-CoV-2 to manage the present novel coronavirus outbreak, and could be beneficial in preventing any future epidemics. Furthermore, the use of green synthesized nanomaterials in the optical biosensor devices could leads to sustainable and environmentally-friendly approaches for addressing this crisis. © 202

Poly(lactic-co-glycolic) acid drug delivery systems through transdermal pathway : an overview

In past few decades, scientists have made tremendous advancement in the field of drug delivery systems (DDS), through transdermal pathway, as the skin represents a ready and large surface area for delivering drugs. Efforts are in progress to design efficient transdermal DDS that support sustained drug release at the targeted area for longer duration in the recommended therapeutic window without producing side-effects. Poly(lactic-co-glycolic acid) (PLGA) is one of the most promising Food and Drug Administration approved synthetic polymers in designing versatile drug delivery carriers for different drug administration routes, including transdermal drug delivery. The present review provides a brief introduction over the transdermal drug delivery and PLGA as a material in context to its role in designing drug delivery vehicles. Attempts are made to compile literatures over PLGA-based drug delivery vehicles, including microneedles, nanoparticles, and nanofibers and their role in transdermal drug delivery of different therapeutic agents. Different nanostructure evaluation techniques with their working principles are briefly explained.RL thanks the funding support from Singapore National Research Foundation under its Translational and Clinical Research Flagship Programme (NMRC/TCR/008-SERI/2013) and administered by the Singapore Ministry of Health’s National Medical Research Council and Co-operative Basic Research Grant from the Singapore National Medical Research Council (Project No. NMRC/CBRG/0048/2013).info:eu-repo/semantics/publishedVersio

Investigation into effects of work-related quality of life and some related factors on cognitive failures among nurses

Objective. Cognitive failure is one of the factors which can be influenced by personal and professional characteristics. This research was carried out to study the effect of work-related quality of life (WRQoL) and some related factors on cognitive failures (CF) among nurses. Methods. This cross-sectional study was conducted among nurses working in intensive care units, critical care units and emergency units in 2014. Results. In total, 750 nurses participated in the study. The mean +/- SD for the total CF and WRQoL was 40.5 +/- 12.7 and 75.8 +/- 13.7 respectively. The results show that CF have a statistically significant difference among the age groups, experience groups and working units. Multiple regression tests show that age, income and WRQoL have a significant effect on CF. Based on the results, for a unit increase in WRQoL we expect a 0.26 unit decrease in CF. Analysis of variance results show that the emergency ward had changed the overall effect of WRQoL on CF, after the effect of WRQoL was controlled. Conclusions. Overall results from the present research indicated that, despite the high level of WRQoL among the studied nurses, the rate of CF was not at an appropriate level. Development of supportive and interventional strategies is highly recommended