Seagull and pion-in-flight currents in neutrino-induced 1N1N and 2N2N knockout

[Background] The neutrino-nucleus ($\nu A$) cross section is a major source of systematic uncertainty in neutrino-oscillation studies. A precise $\nu A$ scattering model, in which multinucleon effects are incorporated, is pivotal for an accurate interpretation of the data. [Purpose] In $\nu A$ interactions, meson-exchange currents (MECs) can induce two-nucleon ($2N$) knockout from the target nucleus, resulting in a two-particle two-hole (2p2h) final state. They also affect single nucleon ($1N$) knockout reactions, yielding a one-particle one-hole (1p1h) final state. Both channels affect the inclusive strength. We present a study of axial and vector, seagull and pion-in-flight currents in muon-neutrino induced $1N$ and $2N$ knockout reactions on $^{12}$C. [Method] Bound and emitted nucleons are described as Hartree-Fock wave functions. For the vector MECs, the standard expressions are used. For the axial current, three parameterizations are considered. The framework developed here allows for a treatment of MECs and short-range correlations (SRCs). [Results] Results are compared with electron-scattering data and with literature. The strengths of the seagull, pion-in-flight and axial currents are studied separately and double differential cross sections including MECs are compared with results including SRCs. A comparison with MiniBooNE and T2K data is presented. [Conclusions] In the 1p1h channel, the effects of the MECs tend to cancel each other, resulting in a small effect on the double differential cross section. $2N$ knockout processes provide a small contribution to the inclusive double differential cross section, ranging from the $2N$ knockout threshold into the dip region. A fair agreement with the MiniBooNE and T2K data is reached.Comment: 16 pages, 10 figure

Impact of low-energy nuclear excitations on neutrino-nucleus scattering at MiniBooNE and T2K kinematics

[Background] Meticulous modeling of neutrino-nucleus interactions is essential to achieve the unprecedented precision goals of present and future accelerator-based neutrino-oscillation experiments. [Purpose] Confront our calculations of charged-current quasielastic cross section with the measurements of MiniBooNE and T2K, and to quantitatively investigate the role of nuclear-structure effects, in particular, low-energy nuclear excitations in forward muon scattering. [Method] The model takes the mean-field (MF) approach as the starting point, and solves Hartree-Fock (HF) equations using a Skyrme (SkE2) nucleon-nucleon interaction. Long-range nuclear correlations are taken into account by means of the continuum random-phase approximation (CRPA) framework. [Results] We present our calculations on flux-folded double differential, and flux-unfolded total cross sections off $^{12}$C and compare them with MiniBooNE and (off-axis) T2K measurements. We discuss the importance of low-energy nuclear excitations for the forward bins. [Conclusions] The CRPA predictions describe the gross features of the measured cross sections. They underpredict the data (more in the neutrino than in the antineutrino case) because of the absence of processes beyond pure quasielastic scattering in our model. At very forward muon scattering, low-energy nuclear excitations ($\omega <$ 50 MeV) account for nearly 50% of the flux-folded cross section.Comment: 8 pages, 9 figures. Version published in Physical Review

Nuclear Structure Physics in Coherent Elastic Neutrino-Nucleus Scattering

The prospects of extracting new physics signals in a coherent elastic neutrino-nucleus scattering (CE$\nu$NS) process are limited by the precision with which the underlying nuclear structure physics, embedded in the weak nuclear form factor, is known. We present microscopic nuclear structure physics calculations of charge and weak nuclear form factors and CE$\nu$NS cross sections on $^{12}$C, $^{16}$O, $^{40}$Ar, $^{56}$Fe and $^{208}$Pb nuclei. We obtain the proton and neutron densities, and charge and weak form factors by solving Hartree-Fock equations with a Skyrme (SkE2) nuclear potential. We validate our approach by comparing $^{208}$Pb and $^{40}$Ar charge form factor predictions with elastic electron scattering data. In view of the worldwide interest in liquid-argon based neutrino and dark matter experiments, we pay special attention to the $^{40}$Ar nucleus and make predictions for the $^{40}$Ar weak form factor and the CE$\nu$NS cross sections. Furthermore, we attempt to gauge the level of theoretical uncertainty pertaining to the description of the $^{40}$Ar form factor and CE$\nu$NS cross sections by comparing relative differences between recent microscopic nuclear theory and widely-used phenomenological form factor predictions. Future precision measurements of CE$\nu$NS will potentially help in constraining these nuclear structure details that will in turn improve prospects of extracting new physics.Comment: 12 pages, 14 figure

PPP1R8 (protein phosphatase 1, regulatory (inhibitor) subunit 8)

Review on PPP1R8 (protein phosphatase 1, regulatory (inhibitor) subunit 8), with data on DNA, on the protein encoded, and where the gene is implicated

Dutch outcome in implantable cardioverter-defibrillator therapy (DO-IT)

Background Implantable cardioverter-defibrillators (ICDs) are widely used for the prevention of sudden cardiac death. At present, both clinical benefit and cost-effectiveness of ICD therapy in primary prevention patients are topics of discussion, as only a minority of these patients will eventually receive appropriate ICD therapy. Methods/design The DO-IT Registry is a nationwide prospective cohort with a target enrolment of 1,500 primary prevention ICD patients with reduced left ventricular function in a setting of structural heart disease. The primary outcome measures are death and appropriate ICD therapy for ventricular tachyarrhythmias. Secondary outcome measures are inappropriate ICD therapy, death of any cause, hospitalisation for ICD related complications and for cardiovascular reasons. As of December 2016, data on demographic, clinical, and ICD characteristics of 1,468 patients have been collected. Follow-up will continue up to 24 months after inclusion of the last patient. During follow-up, clinical and ICD data are collected based on the normal follow-up of these patients, assuming ICD interrogations take place every six months and clinical follow-up i

Immunopathogenesis and Immune Modulation of Venezuelan Equine Encephalitis Virus-Induced Disease in the Mouse

AbstractThe course of Venezuelan equine encephalitis (VEE) disease in immunodeficient and immunologically normal mice was compared to define the role of the immune system in this disease process. Immunocompetent mice infected with VEE exhibited a biphasic illness characterized by an early self-limiting lymphoid phase and a fatal CNS phase. The lymphoid phase of the illness was characterized by extensive viral replication within spleen, thymus, Peyer's patches, and lymph nodes, was accompanied by a high-titered serum viremia, and resolved with the production of VEE-specific IgM class antibody at 72 h postinfection (p.i.). Immunocompetent animals survived an average of 6.8 ± 1.2 days before succumbing to fulminant encephalitis. In contrast, SCID mice infected with VEE showed a persistent replication of virus throughout all organs tested beginning at 24 h p.i. VEE-infected SCID mice exhibited a severe spongiform encephalopathy with 100% mortality and an average survival time of 8.9 ± 0.9 days. These studies indicated that the characteristic organ tropism of VEE in the mouse is due in large part to an early anti-viral state, the establishment of which is dependent upon the presence of an intact immune system. Finally, the CNS pathology in a VEE-infected mouse had a significant immunologic component. However, in contrast to other neurovirulent alphaviruses, VEE was directly cytopathic for the cells of the CNS, even in the absence of an immune response