450 research outputs found
Five new coexisting species of copepod crustaceans of the genus Spaniomolgus (Poecilostomatoida: Rhynchomolgidae), symbionts of the stony coral Stylophorapistillata (Scleractinia)
Spaniomolgus is a symbiotic genus of copepods of the poecilostomatoid family Rhynchomolgidae and is known to be associated with shallow-water reef-building hermatypic corals. Three species of this genus were previously found only in washings of Acropora and Stylophora in northern Madagascar. Four coral morphotypes of Stylophorapistillata (Pocilloporidae) were collected by SCUBA at 1 to 28 m depth in five sites in the Saudi Arabian Red Sea in 2013. Copepods found on these colonies were studied using light, confocal and scanning electron microscopy. Five new, and one known, species of the genus Spaniomolgus were discovered in washings and inside the galls of the hermatypic coral S.pistillata. The description of these new species (Spaniomolgusglobussp. n., S.stylophorussp. n., S.dentatussp. n., S.maculatussp. n., and S.acutussp. n.) and a key for the identification of all of its congeners is provided herein
Effective medium theory of elastic waves in random networks of rods
We formulate an effective medium (mean field) theory of a material consisting
of randomly distributed nodes connected by straight slender rods, hinged at the
nodes. Defining novel wavelength-dependent effective elastic moduli, we
calculate both the static moduli and the dispersion relations of ultrasonic
longitudinal and transverse elastic waves. At finite wave vector the waves
are dispersive, with phase and group velocities decreasing with increasing wave
vector. These results are directly applicable to networks with empty pore
space. They also describe the solid matrix in two-component (Biot) theories of
fluid-filled porous media. We suggest the possibility of low density materials
with higher ratios of stiffness and strength to density than those of foams,
aerogels or trabecular bone.Comment: 14 pp., 3 fig
Boolean Models of Bistable Biological Systems
This paper presents an algorithm for approximating certain types of dynamical
systems given by a system of ordinary delay differential equations by a Boolean
network model. Often Boolean models are much simpler to understand than complex
differential equations models. The motivation for this work comes from
mathematical systems biology. While Boolean mechanisms do not provide
information about exact concentration rates or time scales, they are often
sufficient to capture steady states and other key dynamics. Due to their
intuitive nature, such models are very appealing to researchers in the life
sciences. This paper is focused on dynamical systems that exhibit bistability
and are desc ribedby delay equations. It is shown that if a certain motif
including a feedback loop is present in the wiring diagram of the system, the
Boolean model captures the bistability of molecular switches. The method is
appl ied to two examples from biology, the lac operon and the phage lambda
lysis/lysogeny switch
Quantum state correction of relic gravitons from quantum gravity
The semiclassical approach to quantum gravity would yield the Schroedinger
formalism for the wave function of metric perturbations or gravitons plus
quantum gravity correcting terms in pure gravity; thus, in the inflationary
scenario, we should expect correcting effects to the relic graviton
(Zel'dovich) spectrum of the order (H/mPl)^2
Loop Quantum Cosmology, Boundary Proposals, and Inflation
Loop quantum cosmology of the closed isotropic model is studied with a
special emphasis on a comparison with traditional results obtained in the
Wheeler-DeWitt approach. This includes the relation of the dynamical initial
conditions with boundary conditions such as the no-boundary or the tunneling
proposal and a discussion of inflation from quantum cosmology.Comment: 20 pages, 6 figure
Dynamical Initial Conditions in Quantum Cosmology
Loop quantum cosmology is shown to provide both the dynamical law and initial
conditions for the wave function of a universe by one discrete evolution
equation. Accompanied by the condition that semiclassical behavior is obtained
at large volume, a unique wave function is predicted.Comment: 4 pages, 1 figur
Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology
Human embryonic stem cell (hESC) progenies hold great promise as surrogates for human primary cells, particularly if the latter are not available as in the case of cardiomyocytes. However, high content experimental platforms are lacking that allow the function of hESC-derived cardiomyocytes to be studied under relatively physiological and standardized conditions. Here we describe a simple and robust protocol for the generation of fibrin-based human engineered heart tissue (hEHT) in a 24-well format using an unselected population of differentiated human embryonic stem cells containing 30–40% α-actinin-positive cardiac myocytes. Human EHTs started to show coherent contractions 5–10 days after casting, reached regular (mean 0.5 Hz) and strong (mean 100 µN) contractions for up to 8 weeks. They displayed a dense network of longitudinally oriented, interconnected and cross-striated cardiomyocytes. Spontaneous hEHT contractions were analyzed by automated video-optical recording and showed chronotropic responses to calcium and the β-adrenergic agonist isoprenaline. The proarrhythmic compounds E-4031, quinidine, procainamide, cisapride, and sertindole exerted robust, concentration-dependent and reversible decreases in relaxation velocity and irregular beating at concentrations that recapitulate findings in hERG channel assays. In conclusion this study establishes hEHT as a simple in vitro model for heart research
Period-doubling bifurcation in strongly anisotropic Bianchi I quantum cosmology
We solve the Wheeler-DeWitt equation for the minisuperspace of a cosmological
model of Bianchi type I with a minimally coupled massive scalar field as
source by generalizing the calculation of Lukash and Schmidt [1]. Contrarily to
other approaches we allow strong anisotropy. Combining analytical and numerical
methods, we apply an adiabatic approximation for , and as new feature we
find a period-doubling bifurcation. This bifurcation takes place near the
cosmological quantum boundary, i.e., the boundary of the quasiclassical region
with oscillating -function where the WKB-approximation is good. The
numerical calculations suggest that such a notion of a ``cosmological quantum
boundary'' is well-defined, because sharply beyond that boundary, the
WKB-approximation is no more applicable at all. This result confirms the
adequateness of the introduction of a cosmological quantum boundary in quantum
cosmology.Comment: Latest update of the paper at
http://www.physik.fu-berlin.de/~mbach/publics.html#
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