Potential Immune Biomarkers in Diagnosis and Clinical Management for Systemic Lupus Erythematosus

Background: There is still no reliable, specific biomarker for precision diagnosis and clinical monitoring of systemic lupus erythematosus. The aim of this study was to investigate the importance of the determination of immunofenotypic profiles (T, B lymphocytes and NK cells) and serum cytokine concentrations (IL-17 and IFN-alpha) as potential biomarkers for this disease. Methods: The study included 55 patients with SLE and 25 healthy controls. The proportion of T, B, NK cells were assessed in peripheral blood using flow cytometric assays while the serum cytokine concentration (IL-17 and IFNalpha) was determined by ELISA test. Results: ROC curve analysis showed good accuracy to distinguish between patients and healthy individuals for activated T cells (AUC=0.798; p<0.001), Treg (AUC= 0.651; p=0.036), and memory B cells (AUC=0.285; p=0.002). We found statistically significant difference (p=0.036) in the levels of serum IL-17 between patients with SLE (IL-17=49.27 pg/mL) and controls (IL-17= 28.64 pg/mL). Conclusions: Significant increase in the relative number of Treg lymphocytes, and decrease in memory B cells, as well as decrease level of IL-17, in SLE patients may be implicated in the pathogenesis of the disease. These parameters, as biomarkers, could distinguish SLE patients and no-SLE patients. Monitoring subpopulations of immune cells in peripheral blood using flow cytometry provides insight into abnormal T and B cell function in SLE. Progress in understanding the immunity at SLE, results in concrete benefits for the SLE patients, which include new clinical management and therapeutic strategies

Trade unions and the amendment of the labour code in Romania

Employment relations, as well as issues of social and labour-market reforms or the social dialogue, have been extensively treated by various researches interested in the East and Central European region. In this context, much attention has been paid to the changing roles of trade unions, the problem of re-making ancient structures perverted by their more or less collaboration with the Communist parties from the region and the emergence of new structures in search for legitimisation, the difficulties of trade unionism in articulating and representing interests, an aspect that is directly related to their organisational problems, the relations with the governmental authorities and with the employers' organisations in the tripartite framework, as well as the nature of the tripartism in reuniting social partners and state. This article focuses on national organised labour in Romania in relation to the 2005 Labour Code amendment. This specific level of national interest representation is privileged in order to highlight the peculiarities of recognised representative labour organisations in the post-Communist period. The main assumption is that trade unions are facing a particular policy interest with a shift from fragmentation and unstable co-operation to a ‘common position’. Thus this contribution assesses the determinants defining labour's collaboration while shedding light on state – trade union relations. © 2006 Taylor & Francis.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

The politics of economic adjustment in a liberal market economy : the social compensation hypothesis revisited

Irish Research Council for the Humanities and Social Science