Spatial Attention and Spatial Short Term Memory in PSP and Parkinson’s Disease

Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorder characterised by deterioration in motor, oculomotor and cognitive function. A key clinical feature of PSP is the progressive paralysis of eye movements, most notably for vertical saccades. These oculomotor signs can be subtle, however, and PSP is often misdiagnosed as Parkinson’s disease (PD), in its early stages. Although some of the clinical features of PD and PSP overlap, they are distinct disorders with differing underlying pathological processes, responses to treatment and prognoses. One key difference lies in the effects the diseases have on cognition. The oculomotor system is tightly linked to cognitive processes such as spatial attention and spatial short-term memory (sSTM), and previous studies have suggested that PSP and PD experience different deficits in these domains. We therefore hypothesised that people with PSP (N = 15) would experience problems with attention (assessed with feature and conjunction visual search tasks) and sSTM (assessed with the Corsi blocks task) compared to people with PD (N = 16) and Age Matched Controls (N = 15). As predicted, feature and conjunction search were sgnificantly slower in the PSP group compared to the other groups, and this deficit was significantly worse for feature compared to conjunction search. The PD group did not differ from AMC on feature search but were significantly impaired on the conjunction search. The PSP group also had a pronounced vertical sSTM impairment that was not present in PD or AMC groups. It is argued that PSP is associated with specific impairment of visuospatial cognition which is caused by degeneration of the oculomotor structures that support exogenous spatial attention, consistent with oculomotor theories of spatial attention and memory

A submillimetre survey of the star-formation history of radio galaxies

We present the results of the first major systematic submillimetre survey of radio galaxies spanning the redshift range 1 < z < 5. The primary aim of this work is to elucidate the star-formation history of this sub-class of elliptical galaxies by tracing the cosmological evolution of dust mass. Using SCUBA on the JCMT we have obtained 850-micron photometry of 47 radio galaxies to a consistent rms depth of 1 mJy, and have detected dust emission in 14 cases. The radio galaxy targets have been selected from a series of low-frequency radio surveys of increasing depth (3CRR, 6CE, etc), in order to allow us to separate the effects of increasing redshift and increasing radio power on submillimetre luminosity. Although the dynamic range of our study is inevitably small, we find clear evidence that the typical submillimetre luminosity (and hence dust mass) of a powerful radio galaxy is a strongly increasing function of redshift; the detection rate rises from 15 per cent at z 2.5, and the average submillimetre luminosity rises as (1+z)^3 out to z~4. Moreover our extensive sample allows us to argue that this behaviour is not driven by underlying correlations with other radio galaxy properties such as radio power, radio spectral index, or radio source size/age. Although radio selection may introduce other more subtle biases, the redshift distribution of our detected objects is in fact consistent with the most recent estimates of the redshift distribution of comparably bright submillimetre sources discovered in blank field surveys. The evolution of submillimetre luminosity found here for radio galaxies may thus be representative of massive ellipticals in general.Comment: 31 pages - 10 figures in main text, 3 pages of figures in appendix. This revised version has been re-structured, but the analysis and conclusions have not changed. Accepted for publication in MNRA

The nature of the high boiler degradation products from irradiated Santowax OMP

Based on the 1st author's M.S. thesis, Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1965"MIT-334-11."Includes bibliographical references (pages 89-92)Contract no. AT(38-1)-334M.I.T. DSR Project no. 981

Binary evolution with LOFT

This is a White Paper in support of the mission concept of the Large Observatory for X-ray Timing (LOFT), proposed as a medium-sized ESA mission. We discuss the potential of LOFT for the study of very faint X-ray binaries, orbital period distribution of black hole X-ray binaries and neutron star spin up. For a summary, we refer to the paper.Comment: White Paper in Support of the Mission Concept of the Large Observatory for X-ray Timing. (v2 few typos corrected

Repeated, Delayed Torque Variations Following X-Ray Flux Enhancements in the Magnetar 1E 1048.1-5937

published_or_final_versio

The decontamination of radioactive ion exchange resins using neutral salts as elutriants

Includes bibliographical references (leaves 124-126

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron–oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T₂ MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging

Effects of climate-induced changes in isoprene emissions after the eruption of Mount Pinatubo

In the 1990s the rates of increase of greenhouse gas concentrations, most notably of methane, were observed to change, for reasons that have yet to be fully determined. This period included the eruption of Mt. Pinatubo and an El Nino warm event, both of which affect biogeochemical processes, by changes in temperature, precipitation and radiation. We examine the impact of these changes in climate on global isoprene emissions and the effect these climate dependent emissions have on the hydroxy radical, OH, the dominant sink for methane. We model a reduction of isoprene emissions in the early 1990s, with a maximum decrease of 40 Tg(C)/yr in late 1992 and early 1993, a change of 9%. This reduction is caused by the cooler, drier conditions following the eruption of Mt. Pinatubo. Isoprene emissions are reduced both directly, by changes in temperature and a soil moisture dependent suppression factor, and indirectly, through reductions in the total biomass. The reduction in isoprene emissions causes increases of tropospheric OH which lead to an increased sink for methane of up to 5 Tg(CH4)/year, comparable to estimated source changes over the time period studied. There remain many uncertainties in the emission and oxidation of isoprene which may affect the exact size of this effect, but its magnitude is large enough that it should remain important