Safety performance of school buses in the State of Qatar

School buses and minibuses are one of the major modes of traveling for students in the state of Qatar. Many studies pointed to the fact that school buses travelling are safer for students than walking or car riding (Bolte, et al., 2000; Hinch, et al., 2002). For that reason, safety measures and performance of school buses in the State of Qatar should be studied and evaluated carefully and wisely. The project aims were done through merged qualitative and quantitative methods. Initially a safety checklist was constructed for school buses and a comprehensive schools map to evaluate of the current safety measures in school buses and to understand the conditions around the surrounding areas like the location of the bus stops and the availability of signage. Then, the second step focuses on conducting a survey for school bus drivers, school bus guides, students, and parents. Finally, the third steps compares between the school bus safety strategies followed in the State of Qatar and the strategies followed in other high income countries. The results of the field visits revealed many very important statistics for all surveys on the safety of school bus and the surrounding areas as well as the behavior of students and drivers. The results revealed that most of the parents are not happy with the safety while loading and unloading and with the safety procedures. In addition, 43% of school bus users didn't attend any training or workshops about the safety procedures in school bus. References: [1] Bolte, K. et al., 2000. Simulations of Large School Bus Crashes. [Online] Available at: http://papers.sae.org/2000-01-0469/ [Accessed 10 october 2014]. [2] Hinch, J. et al., 2002. School Bus Safety: Crashworthiness Research, Washington: National Highway Traffic Safety Administration.Qscienc

Validation of the Antiproliferative Effects of Organic Extracts from the Green Husk of Juglans regia L. on PC-3 Human Prostate Cancer Cells by Assessment of Apoptosis-Related Genes

With the increased use of plant-based cancer chemotherapy, exploring the antiproliferative effects of phytochemicals for anticancer drug design has gained considerable attention worldwide. This study was undertaken to investigate the effect of walnut green husk extracts on cell proliferation and to determine the possible molecular mechanism of extract-induced cell death by quantifying the expression of Bcl-2, Bax, caspases-3, and Tp53. PC-3 human prostate cancer cells. In this study, we found that green husk extracts suppressed proliferation and induced apoptosis in a dose- and time-dependent manner by modulating expression of apoptosis-related genes. This involved DNA fragmentation (determined by TUNEL assay) and significant changes in levels of mRNA and the expression of corresponding proteins. An increase in expressions of Bax, caspase-3, and tp53 genes and their corresponding proteins was detected using real-time PCR and western blot analysis in PC-3 cells treated with the green husk organic extracts. In contrast, Bcl2 expression was downregulated after exposure to the extracts. Our data suggest the presence of bioactive compound(s) in walnut green husks that are capable of killing prostate carcinoma cells by inducing apoptosis and that the husks are a candidate source of anticancer drugs

Identification of factors affecting the travel time reliability of public bus transportation - a case study along federal road F0050-route Kluang-A/Hitam-B/Pahat

Public transportation provides basic mobility services to various types of facility actions including those involving education, employment, medical care, and recreation. The general goal of this study was to develop a model with respect to travel time. Public bus transport which connects two cities, A/Hitam- B/Pahat), was selected to conduct this study. Factors such as departure delays, route length, delays at marked traffic light intersections, delays at bus stops, and bus speeds were collected using observation methods. SPSS is a methodological tool used for statistical analysis. The results of the analysis showed a strong positive correlation of ‘0.942’ between travel time and route length, a moderate positive correlation of ‘0.697’ between travel time and delay at marked traffic light intersections, a weak correlation of ‘0.272’ between travel and departure time. delay with a significance level of 0.05. The determination coefficient showed a great regression explanatory power with R2 = 0.954. and (P <0.001). SPSS is also used to examine the data and generate models

Unifying linguistic annotations and ontologies for the Arabic Quran

The WACL’2 Second Workshop on Arabic Corpus Linguistics was held in conjunction with the Corpus Linguistics 2013 conference. Following on from the successful first WACL in 2011, as well as the related LRE-REL event in 2012, WACL-2 again took place at Lancaster University. The aim of this series of workshops is to create a venue for exploring progress in the field of research into the Arabic language using corpora, from across the many areas of corpus linguistics and computational linguistics where the analysis of Arabic structure and usage is an active issue. The scope of the workshop encompasses both (a) the design, construction and annotation of Arabic corpora, and (b) the use of corpora in research on the Arabic language – in any relevant area, including (but not limited to!) lexis and lexicography, syntax, collocation, NLP systems and analysis tools, contrastive and historical studies, stylistics, and discourse analysis. All varieties of Arabic – including the different Colloquial Arabics as well as Classical/Qur’anic and Modern Standard forms of the language – are within the workshop's purview

HIV- 1 lentivirus tethering to the genome is associated with transcription factor binding sites found in genes that favour virus survival

Lentiviral vectors (LV) are attractive for permanent and effective gene therapy. However, integration into the host genome can cause insertional mutagenesis highlighting the importance of understanding of LV integration. Insertion site (IS) tethering is believed to involve cellular proteins such as PSIP1/LEDGF/p75, which binds to the virus pre-integration complexes (PICs) helping to target the virus genome. Transcription factors (TF) that bind both the vector LTR and host genome are also suspected influential to this. To determine the role of TF in the tethering process, we mapped predicted transcription factor binding sites (pTFBS) near to IS chosen by HIV-1 LV using a narrow 20 bp window in infected human induced pluripotent stem cells (iPSCs) and their hepatocyte-like cell (HLC) derivatives. We then aligned the pTFBS with these sequences found in the LTRs of native and self-inactivated LTRs. We found significant enrichment of these sequences for pTFBS essential to HIV-1 life cycle and virus survival. These same sites also appear in HIV-1 patient IS and in mice infected with HIV-1 based LV. This in silco data analysis suggests pTFBS present in the virus LTR and IS sites selected by HIV-1 LV are important to virus survival and propagation

Four Lessons in Versatility or How Query Languages Adapt to the Web

Exposing not only human-centered information, but machine-processable data on the Web is one of the commonalities of recent Web trends. It has enabled a new kind of applications and businesses where the data is used in ways not foreseen by the data providers. Yet this exposition has fractured the Web into islands of data, each in different Web formats: Some providers choose XML, others RDF, again others JSON or OWL, for their data, even in similar domains. This fracturing stifles innovation as application builders have to cope not only with one Web stack (e.g., XML technology) but with several ones, each of considerable complexity. With Xcerpt we have developed a rule- and pattern based query language that aims to give shield application builders from much of this complexity: In a single query language XML and RDF data can be accessed, processed, combined, and re-published. Though the need for combined access to XML and RDF data has been recognized in previous work (including the W3C’s GRDDL), our approach differs in four main aspects: (1) We provide a single language (rather than two separate or embedded languages), thus minimizing the conceptual overhead of dealing with disparate data formats. (2) Both the declarative (logic-based) and the operational semantics are unified in that they apply for querying XML and RDF in the same way. (3) We show that the resulting query language can be implemented reusing traditional database technology, if desirable. Nevertheless, we also give a unified evaluation approach based on interval labelings of graphs that is at least as fast as existing approaches for tree-shaped XML data, yet provides linear time and space querying also for many RDF graphs. We believe that Web query languages are the right tool for declarative data access in Web applications and that Xcerpt is a significant step towards a more convenient, yet highly efficient data access in a “Web of Data”

Is there a role for melatonin in fibromyalgia?

Fibromyalgia, characterised by persistent pain, fatigue, sleep disturbance and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis. Heterogeneity of clinical expression of fibromyalgia with a multifactorial aetiology has made the development of effective therapeutic strategies challenging. Physiological properties of the neurohormone melatonin appear related to the symptom profile exhibited by patients with fibromyalgia and thus disturbance of it’s production would be compatible with the pathophysiology. Altered levels of melatonin have been observed in patients with fibromyalgia which are associated with lower secretion during dark hours and higher secretion during daytime. However, inconsistencies of available clinical evidence limit conclusion of a relationship between levels of melatonin and symptom profiles in patients with fibromyalgia. Administration of melatonin to patients with fibromyalgia has demonstrated suppression of many symptoms and an improved quality of life consistent with benefit as a therapy for the management of this condition. Further studies with larger samples, however, are required to explore the potential role of melatonin in the pathophysiology of fibromyalgia and determine the optimal dosing regimen of melatonin for the management of fibromyalgia