43 research outputs found
Genetic variability and structure of jaguar (Panthera onca) in Mexican zoos
ArtículoGenealogical records of animals (studbook) are
created to avoid reproduction between closely related
individuals, which could cause inbreeding, particularly for
such endangered species as the Panthera onca (Linnaeus,
1758). Jaguar is the largest felid in the Americas and is
considered an important ecological key species. In Mexico,
wild jaguar populations have been significantly reduced in
recent decades, and population decline typically accompany decreases in genetic variation. There is no current
census of captive jaguars in Mexico, and zoos do not follow a standardized protocol in breeding programs based on
genetic studies. Here, we emphasise the importance of
maintaining an adequate level of genetic variation and
propose the implementation of standardised studbooks for
jaguars in Mexico, mainly to avoid inbreeding. In addition,
achieving the aims of studbook registration would provide
a population genetic characterisation that could serve as a
basis for ex situ conservation programmes
Diversity and distribution of mollusks along the Contas River in a tropical semiarid region (Caatinga), Northeastern Brazil
The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
An immunohistochemical study of the tonsils in pigs with acute African swine fever virus infection.
An immunohistochemical study of the tonsils was carried out to gain further insight in the pathogenesis of acute African swine fever (ASF). Twenty-one pigs were inoculated by intramuscular route with a highly virulent isolate of ASF virus and painlessly killed at 1-7dpi. Viral antigen was highly distributed in the tonsil from 3 to 4dpi and an increase in the number of monocyte-macrophages was very evident at the same days post inoculation. This phenomenon was observed together with an increase of the expression of proinflammatory cytokines (Tumour necrosis factor alpha and Interleukin-1 alpha) and the apoptosis of lymphocytes studied by the terminal deoxynucleotidyltransferase-mediated dUTP nick end labelling (TUNEL) technique and haemorrhages. With these results, we can conclude that the tonsil is suffering similar lesions than those observed in other lymphoid organs in acute African swine fever, even when the route of inoculation is the intramuscular and not oral-nasal
An immunohistochemical study of the tonsils in pigs with acute African swine fever virus infection.
An immunohistochemical study of the tonsils was carried out to gain further insight in the pathogenesis of acute African swine fever (ASF). Twenty-one pigs were inoculated by intramuscular route with a highly virulent isolate of ASF virus and painlessly killed at 1-7dpi. Viral antigen was highly distributed in the tonsil from 3 to 4dpi and an increase in the number of monocyte-macrophages was very evident at the same days post inoculation. This phenomenon was observed together with an increase of the expression of proinflammatory cytokines (Tumour necrosis factor alpha and Interleukin-1 alpha) and the apoptosis of lymphocytes studied by the terminal deoxynucleotidyltransferase-mediated dUTP nick end labelling (TUNEL) technique and haemorrhages. With these results, we can conclude that the tonsil is suffering similar lesions than those observed in other lymphoid organs in acute African swine fever, even when the route of inoculation is the intramuscular and not oral-nasal
AN APPLICATION OF THE IDEA MODEL IN THE ASSESSMENT OF CONTAINER TERMINALS EFFICIENCY WITH AN INTANGIBLE INPUT
Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin
Does teacher homework feedback matter to 6th graders' school engagement?: a mixed methods study
The effectiveness of homework on improving student academic achievement depends on several factors; for example, feedback provided by the teacher (i.e. grading) and student engagement are important moderators in this process. However, the relationships between the types of homework feedback commonly used by teachers and student school engagement have not yet been examined. Anchored in the Self-Determination Theory, this mixed methods sequential explanatory study investigated how five types of teacher homework feedback predict three dimensions of students' school engagement. The participants included 6th graders (N = 4288) and their mathematics teachers (N = 170). For this investigation, a quantitative phase was run, followed by a qualitative phase. The quantitative data were analyzed using multivariate multilevel regression models. The quantitative data showed positive relationships between five types of feedback and school engagement, albeit with different results at student and class levels. The findings showed small effect sizes. The qualitative data, based on a purposeful sampling, provided further insights regarding the low effect sizes that were found. Data were analyzed using thematic analysis. Four themes were identified as follows: homework at home and/or at the study center, perceived homework feedback types, school engagement, and school disaffection. Both data sets indicated directions to strengthen the benefits of homework feedback and to maximize students' learning. This research paper discusses practical implications as well as future research directions.This study was conducted at Psychology Research Centre (UID/PSI/01662/2013), University of Minho, and supported by the Portuguese Foundation for Science and Technology and the Portuguese Ministry of Science, Technology and Higher Education through national funds and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007653). The first author was supported by a PhD fellowship from the Portuguese Foundation for Science and Technology (FCT – SFRH/BD/95341/2013)