19 research outputs found
Potenciális királis farmakonok kromatográfiás kölcsönhatásainak vizsgálata királis állófázisokon : [absztrakt]
Investigation of enantioselective HPLC separations of fluorinated β3-phenylalanine derivatives
HPLC separations of N-Azole compounds in polar organic and normal phase mode utilizing amylose-based chiral stationary phases : [abstract]
Enantioselective separation of substituted amino acids utilizing cinchona alkaloid-based chiral stationary phases : [abstract]
Enantiomeric separation of newly synthesized amino, thio, and oxy derivatives of monoterpene lactones, amides, and ester applying polysaccharide-based chiral stationary phases in normal-phase mode
High-performance liquid chromatographic enantioseparation of azole analogs of monoterpene lactones and amides focusing on the separation characteristics of polysaccharide-based chiral stationary phases
Enantioselective high-performance liquid chromatographic separation of fluorinated Ăź- phenylalanine derivatives utilizing Cinchona alkaloid-based ion-exchanger chiral stationary phases : Enantioselective separation of fluorinated Ăź-phenylalanine derivatives
Algebrai logika; relativitáselmélet logikai struktúrájának vizsgálata = Algebraic logic; investigating the logical structure of relativity theory
Gödel, Einstein Ă©s Tarski hagyományait kĂvánjuk folytatni, elmĂ©lyĂtve a Gödel-Einstein egyĂĽttműködĂ©s eredmĂ©nyeit is, Ă©s folytatva Tarski tudományegyesĂtĂ©si programmját. Ismert, hogy a logika Ă©s a matematika modern megalapozása Gödel Ă©s Tarski ĂşttörĹ‘ munkásságára vezethetĹ‘ vissza. KevĂ©sbbĂ© ismert, hogy Gödel 1948-tĂłl majdnem Ă©lete vĂ©gĂ©ig Einsteinnel szorosan egyĂĽttműködve relativitáselmĂ©leten dolgozott, ahol ugyanolyan meghökkentĹ‘ Ăşj horizontokat tárt fel mint logikában, Ă©s hogy Gödel relativitáselmĂ©leti gondolatai folytatásakĂ©nt foghatĂł fel a forgĂł fekete lyukak mai elmĂ©lete. Ezen elĹ‘zmĂ©nyek folytatása a jelen projektum, mely Tarskival Ă©s munkatársaival valĂł szemĂ©lyes egyĂĽttműködĂ©s (pl. közös könyv) keretĂ©ben kezdĹ‘dött. Az alapgondolat a logika, algebra, geometria, tĂ©ridĹ‘elmĂ©let Ă©s relativitáselmĂ©let egysĂ©gben valĂł művelĂ©se. EredmĂ©nyeinkbĹ‘l egy pĂ©lda: Nagy, lassan forgĂł fekete lyukakrĂłl bizonyĂtottuk, hogy a belsejĂ©ben lĂ©trejövĹ‘ un. zárt idĹ‘szerű görbe (idĹ‘hurok) lĂ©trejöttĂ©re vonatkozĂł szokásos irodalmi magyarázatok tĂ©vesek. Nem az un. drag effect (mozgĂł anyag magával vonszolja a tĂ©ridĹ‘t) okozza a zárt görbĂ©ket, hanem egy egĂ©szen más jellegű hatás: a fĂ©nykĂşpok kinyĂlása a forgással ellentĂ©tes irányban. Az eredmĂ©ny a General Relativity and Gravitation cĂmű folyĂłiratban jelenik meg. | The reported project intends to continue traditions of Gödel, Einstein and Tarski continuing the spirit of the Gödel-Einstein collaboration and pursuing Tarski's programme for unifying science. Modern logic and meta-mathematics was created (basically) by Gödel and Tarski. It is less well known that beginning with 1948 Gödel spent much time with Einstein and worked on relativity theory. Of course, he remained a logician in spirit. Gödel obtained fundamental breakthroughs in relativity like his ones in logic and foundations. The theory of general relativistic spacetimes not admitting a global Time was initiated by Gödel, and came to full blossom during the renaissance of black hole physics during the last 25 years. The present project was originally started in personal cooperation with Tarski and his collaborators. The idea is to study logic, algebra, geometry, spacetime theory and relativity in a strong unity. A sample result of ours: We proved about big, slowly rotating black holes that the usual explanation in the literature of why such black holes contain a closed timelike curve (CTC) is flawed. Namely, it is not the gravitational frame dragging effect which creates CTCs, instead, there is a completely different kind of effect in action there: light cones open up in the direction opposite to that of the rotation of the source and this goes on to such an extreme extent that CTCs are created. Our paper on this appears in the journal General Relativity and Gravitation
Chiral high-performance liquid and supercritical fluid chromatographic enantioseparations of limonene-based bicyclic aminoalcohols and aminodiols on polysaccharide chiral stationary phases
Chirality is extremely important for the modern pharmaceutical industry since many drug compounds are chiral molecules whose stereoisomers usually possess various toxicological and pharmacological properties. One of the enantiomers (eutomer) have the desired pharmacological activity, while the other isomer (distomer) is inactive or in worst cases some undesirable effects or even toxic effect can also be produced. The investigated compounds were limonene-based bicyclic 1,3-aminoalcohols and 1,3,5- and 1,3,6-aminodiols. In recent years, these compounds have been intensively investigated due to their potential biological activity and their benefits in synthetic chemistry. Aminoalcohols and aminodiols are known to be outstanding building blocks for the synthesis of remarkable heterocyclic compounds. Aminodiol-based nucleoside analogs possess noteworthy antitumor or antiviral activity [1]. The synthesis of new, limonene-based chiral bicyclic 1,3- aminoalcohols and aminodiols from commercially available starting materials have recently been reported [2]. As a result of the pharmaceutical and biological activity of chiral 1,3-aminoalcohols and aminodiols, it is very important to have at hand enantioselective analytical methods for the identification and separation of these compounds. Enantioseparations of limonene-based bicyclic 1,3-aminoalcohols and 1,3,5- and 1,3,6-aminodiols were carried out with highperformance liquid chromatographic and supercritical fluid chromatographic (SFC) methods on commercial polysaccharide-based chiral stationary phases. The effects of the mobile phase composition, the nature and concentration of the alcohol additive, the temperature and the structures of the studied analytes on the separations were investigated in the normal phase and SFC mode. The elution sequence was determined in all cases. The separations of the stereoisomers of the investigated analytes were optimized in both chromatographic modes