Berkecz Róbert

Ilisz István

Lindner Wolfgang

Németi Gábor

Ozsvár Dániel

Péter Antal

English

University of Szeged

29th International Symposium on Analytical and Environmental Problems  42  ENANTIOSELECTIVE SEPARATION OF SUBSTITUTED AMINO ACIDS UTILIZING CINCHONA ALKALOID-BASED CHIRAL STATIONARY PHASES  Gábor Németi*1, Dániel Ozsvár1, Róbert Berkecz1, Antal Péter1, Wolfgang Lindner2, István Ilisz1  1Institute of Pharmaceutical Analysis, University of Szeged, H-6720 Szeged, Somogyi u. 4, Hungary 2Department of Analytical Chemistry, University of Vienna, Währingerstrasse 38, 1090 Vienna, Austria e-mail: nemeti.gabor@szte.hu  Applying chiral stationary phases is a highly favored choice for enantioseparation purposes due to its versatility both in analytical and preparative scales. Among others, Cinchona alkaloid-based ion-exchanger type chiral stationary phases are particularly noteworthy in the case of enantioseparation of amino acids and their derivatives.  The changes in the chromatographic parameters were investigated by varying of the methanol and acetonitrile content of the bulk solvent, the nature of the acid and base additives, and the temperature of the stationary phase. The stoichiometric displacement model was used to study ionic interactions by varying the concentration of the additives. Evaluation of structure-retention relationships was done on the basis of the effects of the various structures of the applied analytes and the elution order of their stereoisomers utilizing different selectors as stationary phases.  Acknowledgments The study was supported by the ÚNKP-23-3-SZTE-191 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. This work was also supported by the National Research, Development and Innovation Office-NKFIA through project K137607. Project no. TKP2021-EGA-32 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme.  

Enantioselective separation of substituted amino acids utilizing cinchona alkaloid-based chiral stationary phases : [abstract]

http://acta.bibl.u-szeged.hu/82355/1/proceedings_of_isaep_2023_042.pdf

Enantioselective separation of substituted amino acids utilizing cinchona alkaloid-based chiral stationary phases : [abstract]

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