Viagem à Índia para prospecção de tecnologias sobre mamona e pinhão manso.

Viagem á Índia para prospecção de tecnologias sobre mamona e pinhão manso ; Introdução; Roteiro; Detalhamento; Sardar Krushinagar Dantiwada University; Pesquisas com mamona; Pesquisas com pinhão manso; Outras oleaginosas ; Indústria de extração de óleo de mamona ; Mercado de leilões para comercialização de produtos agrícolas ; Mini-usina de biodiesel de pinhão manso; 4º Seminário Internacional sobre semente e óleo de mamona e produtos de valor agregado ; Visita à Secretaria de Agricultura do Estado de Tamil Nadu ; Projeto MGR jatropha biodiesel ; Loco Works - Empresa operadora de ferrovias ; Exposição sobre a mini-usina de biodiesel da Empresa Loco Works ; Considerações finais; Pinhão manso ; Mamona.bitstream/CNPA/18319/1/DOC153.pd

Fractional bioheat equation

In this work we develop a new mathematical model for the Pennes’ bioheat equation assuming a fractional time derivative of single order. A numerical method for the solu- tion of such equations is proposed, and, the suitability of the new model for modelling real physical problems is studied and discussedCOMPETE, FEDER and Fundação para a Ciência e a Tecnologia (the Portuguese Foundation for Science and Technology (FCT)) through Projects UID/CTM/50025/2013, PTDC/EME- MFE/113988/2009 and EXPL/CTM-POL/1299/2013. M. Rebelo acknowledge financial funding by the Portuguese Foundation for Science and Technology through the project PEstOE/MAT/UI0297/2013 (Centro de Matemática e Aplicacões

Metodologia científica: aperfeiçoamento metodológico para digestão assistida via micro-ondas na análise mineral de feijoeiro comum (Phaseolus vulgaris L.).

O objetivo deste trabalho foi determinar a eficiência na recuperação de minerais por meio do método de digestão em micro-ondas adaptado e analisar se essa recuperação é confiável com o uso de menor volume de ácido nítrico, otimizando-se, desta forma, o método. Neste comunicado, são relatadas todas as etapas e procedimentos para a condução das análises, assim como, discutidos os resultados e o alcance dos principais objetivos do trabalho com base em análise estatística e cálculo do Z Score.bitstream/item/30834/1/comt196.pd

Are the Tails of Percolation Thresholds Gaussians ?

The probability distribution of percolation thresholds in finite lattices were first believed to follow a normal Gaussian behaviour. With increasing computer power and more efficient simulational techniques, this belief turned to a stretched exponential behaviour, instead. Here, based on a further improvement of Monte Carlo data, we show evidences that this question is not yet answered at all.Comment: 7 pages including 3 figure

Soil moisture on emergence and initial development of Bidens pilosa.

Some species are used as cover crops, so they can produce and release products from their secondary metabolism. When these products are released in the environment, they are exposed to direct or indirect influences. Thus, this trial aimed to evaluate the influence of soil moisture content in plant decomposition, possibly caused by allelochemicals release. The influence of soil field capacity was evaluated by the decomposition of black oats (Avena strigosa Schreb), turnip (Vicia villosa Roth) and hairy vetch (Raphanus sativus L.) residues, with 70 and 50% of water availability and the control. Pots (1.0 kg) were filled with sterilized and unsterilized soil, plus 30 g of plant residue, which remained in decomposition for four weeks before the experiment start. After that, five seeds of beggartick (Bidens pilosa L.) were sowed and seedling emergence was daily evaluated for 10 d. The emergence speed index and emergence speed were calculated. Five seedlings were transplanted at the 8th d and evaluated during 30 d, to obtain the initial development of plants, and to determine fresh and dry mass. Greatest growth inhibition of the weed tested occurred with 70% available water for plant emergence and with 50% for initial plant development

Coronary artery bypass surgery and longitudinal evaluation of the autonomic cardiovascular function

INTRODUCTION: Imbalance in autonomic cardiovascular function increases the risk for sudden death in patients with coronary artery disease (CAD), but the time course of the impact of coronary artery bypass grafting (CABG) on autonomic function has been little studied. Thus, the purpose of the present study was to determine the effects of the CABG on the cardiovascular autonomic function. METHODS: Patients undergoing CABG (n = 13) and two matched control groups (patients with CAD who refused surgical treatment [n = 9], and healthy volunteers [n = 9]) underwent a prospective longitudinal study consisting of autonomic evaluation before and after (3, 6, 15, 30, 60, and 90 days) surgery, including measurement of heart rate variability (HRV), respiratory sinus arrhythmia (RSA), and Valsalva maneuver. RESULTS: After CABG there was a decrease in, and a later recovery of, (1) the HRV in the time domain and in the frequency domain, (2) RSA, and (3) Valsalva maneuver. CONCLUSIONS: CABG caused an impairment, reversible after 60 days, of cardiovascular autonomic function, with a maximal decrease on about the sixth day after surgery

A flexible-docking approach for the design of novel cancer peptidomimetic drugs

Cancer is the second leading cause of death worldwide and the lack of alternative therapies has kept patients dependent on classic chemotherapy. The most occurring form of cancer amongst women is breast cancer and the triple negative cell subtype (TNBC) is responsible for a high metastatic and mortality rate, as it presents molecular and genetic shifts, lacks specific targeting and responds poorly to existing therapies. Recent studies have provided convincing evidence that the therapeutic outcome of chemotherapy may be affected by the expression and activity of receptor tyrosine kinases and their phosphatase pathways (MAPK/ERK, PI3/AKT, among others). These proteins are implicated in mechanisms of cell survival, drug resistance and Epithelial-Mesenchymal Transition (EMT), and are therefore key targets for TNBC cancer cell subtype. However, many inhibitors developed for these targets have not succeeded at a clinical level and present low solubility. As a result of the pronounced decline in productivity experienced by drug discovery efforts in the last years, novel approaches to the rational design of new drugs are now being pursued. A potential solution might be the use of natural or synthetic peptides and peptidomimetics targeting protein-protein interactions essential for signaling networks function. The combination of several bioinformatic approaches (docking, virtual screening, pharmacophore models, among others) allows the use of the vast amount of existing information on available compounds and protein-protein interactions in structural databases. In this study we designed a procedure for small peptidomimetics structure-based rational drug design capable of blocking the active sites of SNAiL1, a protein that has been suggested as a potent repressor of E-cadherin expression and consequently, as an inducer of EMT transition in TNBCs. A random library was created using a composite approach for drug-like compound identification from the PubChem and Development Therapeutics NCI/NIH compound databases, which combined structure-based virtual screening (known motifs of peptide structures within proteins and small molecules) and Z-score comparison. Docking studies were performed to map the polypeptides activity and stability: (1) point alteration studies using non-natural aminoacids for helical stability over a wider range (since linear peptides adopt many confirmations in aqueous solution) using Ramachandran plot dihedral angles estimation; (2) quantitative structure-activity relationships (QSAR) using radical modification chemical studies and (3) umbrella sampling for dissociations studies. The peptidomimetic SNAiL1 model created suggested at least two radical modifications for a strong inhibition