26 research outputs found
Thermodynamics of SU(N) Yang-Mills theories in 2+1 dimensions II - The deconfined phase
We present a non-perturbative study of the equation of state in the
deconfined phase of Yang-Mills theories in D=2+1 dimensions. We introduce a
holographic model, based on the improved holographic QCD model, from which we
derive a non-trivial relation between the order of the deconfinement phase
transition and the behavior of the trace of the energy-momentum tensor as a
function of the temperature T. We compare the theoretical predictions of this
holographic model with a new set of high-precision numerical results from
lattice simulations of SU(N) theories with N=2, 3, 4, 5 and 6 colors. The
latter reveal that, similarly to the D=3+1 case, the bulk equilibrium
thermodynamic quantities (pressure, trace of the energy-momentum tensor, energy
density and entropy density) exhibit nearly perfect proportionality to the
number of gluons, and can be successfully compared with the holographic
predictions in a broad range of temperatures. Finally, we also show that, again
similarly to the D=3+1 case, the trace of the energy-momentum tensor appears to
be proportional to T^2 in a wide temperature range, starting from approximately
1.2 T_c, where T_c denotes the critical deconfinement temperature.Comment: 2+36 pages, 10 figures; v2: comments added, curves showing the
holographic predictions included in the plots of the pressure and energy and
entropy densities, typos corrected: version published in JHE
Umbilical cord blood DNA methylation in children who later develop type 1 diabetes
Aims/hypothesis: Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes.Methods: Reduced representation bisulphite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study. Children later diagnosed with type 1 diabetes and/or who tested positive for multiple islet autoantibodies (n = 43) were compared with control individuals (n = 79) who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis.Results: No differences in the umbilical cord blood methylation patterns were observed between the cases and controls at a false discovery rate Conclusions/interpretation: Based on our results, differences between children who progress to type 1 diabetes and those who remain healthy throughout childhood are not yet present in the perinatal DNA methylome. However, we cannot exclude the possibility that such differences would be found in a larger dataset.</p