Hantaviral proteins: Structure, functions, and role in hantavirus infection

© 2015 Muyangwa, Martynova, Khaiboullina, Morzunov and Rizvanov. Hantaviruses are the members of the family Bunyaviridae that are naturally maintained in the populations of small mammals, mostly rodents. Most of these viruses can easily infect humans through contact with aerosols or dust generated by contaminated animal waste products. Depending on the particular Hantavirus involved, human infection could result in either hemorrhagic fever with renal syndrome or in Hantavirus cardiopulmonary syndrome. In the past few years, clinical cases of the Hantavirus caused diseases have been on the rise. Understanding structure of the Hantavirus genome and the functions of the key viral proteins are critical for the therapeutic agents' research. This paper gives a brief overview of the current knowledge on the structure and properties of the Hantavirus nucleoprotein and the glycoproteins

Transport diplomacy The politics of transport cooperation in the Southern african Development Coordination Conference

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Molecular activation mechanisms of antiviral response and intracellular transport of hantavirus N protein in vitro: an abstract of a thesis presented for the degree of doctor of philosophy: 03.01.04 – Biochemistry

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“俫人”族源浅探

我国“俫人”分布于黔桂滇三省(区)交接地带.解放三十多年来,一直未能确定其民族成份.近年来,虽引起一些专家学者的注意,然而见仁见智,看法不一.综观其研究动态,关键在于尚未对其族源问题进行过系统的探讨.笔者认为,探讨“俫人”族源,是件很有意义的事,它不仅仅是目前解决“俫人”族属问题的关键之一,而且还牵涉到汉藏语系各语族先民之间,及其与南亚语系孟高棉语族先民之间的历史关系.深入、系统地探讨这一课题,将对解决西南民族关系史中的一些疑难问题起一定的积极作用.然而,课题难度较大,非一两篇文章便可搞清,当循序分别讨论.本文为“俫”源初溯,旨在给“俫人”族属识别提供参考意见.概而言之,古今“俫人”的概念不同,今自报“俫人”的族源出自仡

Lentivirus Expression of Hantavirus Nucleocapsid Proteins

© 2016, Springer Science+Business Media New York.Hantaviruses are classified as category A pathogens due to the high mortality rate and potential for major health impact. Therefore, virus propagation is restricted to the Biological Safety Level-3 containment laboratory. In this work, we utilized the recombinant lentivirus delivery system which can be used in Biological Safety Level-2 containment. Recombinant lentiviruses were obtained using Gateway cloning technology. Lentiviruses containing S segment of Hantaan, Sin Nombre, Prospect Hill, or Andes viruses were used to transduce lung carcinoma epithelial type II cells (A549). Accumulation of hantavirus S segment RNA was detected using real-time PCR. Additionally, expression of hantavirus nucleocapsid protein was detected in cells transduced with lentiviruses coding for hantavirus S segment. Hantavirus N proteins were found localized in perinuclear region. Interestingly, localization of N protein was similar to that found in hantavirus infected cells. Therefore, we suggest that lentivirus delivery approach could be used to study the mechanisms of hantavirus pathogenesis in Biological Safety Level-2 containment

Hantaviral proteins: Structure, functions, and role in hantavirus infection

© 2015 Muyangwa, Martynova, Khaiboullina, Morzunov and Rizvanov. Hantaviruses are the members of the family Bunyaviridae that are naturally maintained in the populations of small mammals, mostly rodents. Most of these viruses can easily infect humans through contact with aerosols or dust generated by contaminated animal waste products. Depending on the particular Hantavirus involved, human infection could result in either hemorrhagic fever with renal syndrome or in Hantavirus cardiopulmonary syndrome. In the past few years, clinical cases of the Hantavirus caused diseases have been on the rise. Understanding structure of the Hantavirus genome and the functions of the key viral proteins are critical for the therapeutic agents' research. This paper gives a brief overview of the current knowledge on the structure and properties of the Hantavirus nucleoprotein and the glycoproteins