North by Northwest : Information literacy at Yukon College and Lakehead University

In Northern communities, isolation is a fact of life and common southern "realities" like high-speed internet, libraries (both public and academic) within driving distance and f2f instruction are not the norm. Due to these factors, online instruction is a core component in northern academic institutions and as such requires a little bit more preparation. As well, another key factor to consider is the diverse student population: First Nations, mature, part-time, first generation university students, and professionals upgrading their credentials. The diverse academic backgrounds of these students makes designing the standard library tutorial a challenge; one size does not fit all in the north. At the same time, this might be the only way that students interact with a librarian so the online environment becomes significant to these students' academic studies (and hopefully success). So how does an academic library with such a variety of students a) reach these students? b) design online tutorials targeting a variety of learning styles? and c) assess whether any of this is working? This session will show you how to take a generic one hour information literacy class and turn it into an online session that will meet the needs of a diverse student population. The presenters will discuss effective pedagogical approaches to online instruction, how to teach specific e-resources and finally how to ensure that the students are actually finding the Library's e-resources and using them effectively and efficiently. This presentation won't focus as much on software, although we will be discussing what we use, it's more about how to use the software to teach InfoLit online effectively. We will conclude with a discussion on how to beta-test your new online approach to Information Literacy Instruction before launching it live for the students. So, come to this session and see how two northern (Ontario and Yukon) librarians are devising new and alternative methods of reaching out to students via a variety of methods and assessing their efforts. How, in fact, we have to examine "every angle" such as mode of delivery, type of student, pedagogical theory, etc. to ensure that we are serving our diverse populations well and contributing to the retention and success of these students

Reconstructing Neogene surface uplift of the Alps: Integrating stable isotope paleoaltimetry and paleoclimate modelling

Paleoaltimetry - the reconstruction of the elevation of mountain ranges in the geological past - is key to understanding the geodynamic drivers of surface uplift. Simultaneously, surface uplift of Earth’s major mountain ranges redirected atmospheric flow and impacted climate globally. At a smaller scale, mountain building affects regional climate and biodiversity. Stable isotope paleoaltimetry is a powerful tool to quantify the past elevation of mountain ranges. It is based on the inverse relationship between the stable isotopic composition of meteoric waters and elevation, which is represented by the so-called isotopic lapse rate. However, variations in climatic parameters modify isotopic lapse rates and impact moisture transport over the continents and consequently affect paleoelevation reconstructions. Here, we show the results of a combined stable isotope paleoaltimetry and paleoclimate modeling approach in the European Alps. This approach allows for an improved and more realistic estimation of isotopic lapse rates, large-scale isotope-in-precipitation patterns over Europe and hence Alpine paleoaltimetry calculations. The European Alps are an ideal target for a combined paleoaltimetry - climate modeling approach, given that they are (a) one of the most-studied mountain ranges for which many geoscientific data are available, and (b) sufficiently small and oriented near-parallel to dominant atmospheric circulation patterns. The latter implies that no major global climatic changes are expected in response to Alpine surface uplift, as opposed to e.g. the Andes or the Tibet-Himalaya mountain ranges. Results from 4D-MB SPP phase 1 and 2 show that: (1) Changing the surface elevation of even a small orogen can complicate stable isotope paleoaltimetry by mixing the elevation and climate signal in a more complex way than commonly assumed. Climate models can help separate these signals and constrain surface uplift histories. (2) The Central Alps were already high during the Early and Middle Miocene, whereas the Eastern Alps were still at significantly lower elevations, thereby confirming that surface uplift propagated from west to east, as would be expected from oblique continent-continent collision. Together, the results highlight the importance and viability of this combined, interdisciplinary approach. Based on the results from 4D-MB SPP phase 1 and 2, we propose that future efforts to reconstruct surface uplift of mountain ranges follow this state-of-the-art approach, while keeping local limitations to proxy material availability and access to facilities in mind

Justice and Natural Resources: Concepts, Strategies, and Applications

This digital resource contains only an abstract, cover image and table of contents information from the published book. Print copy of book is available in the University of Colorado\u27s Wise Law Library: http://128.138.161.92/record=b257401 Contents: PART ONE : FRAMEWORKS: Beyond traditional environmental justice / David H. Getches, David N. Pellow -- Assessing claims of environmental justice : conceptual frameworks / Gary C. Bryner -- Water, poverty, equity, and justice in Colorado : a pragmatic approach / James l. Wescoat Jr., Sarah Halvorson, Lisa Headington, Jill Replogle -- International environmental protection : human rights and North-South divide / Tseming Yang -- PART TWO : CONCEPTS: The coincidental order of environmental injustice / Jeff Romm -- Environmental justice in an era of devolved collaboration / Sheila Foster -- Tribal sovereignty and environmental justice / Sarah Krakoff -- PART THREE : STRATEGIES AND APPLICATIONS: Expanding civil rights protections in contested terrain : using Title VI of the Civil Rights Act of 1964 / Luke W. Cole -- Forest management and environmental justice in northern New Mexico / Henry H. Carey -- NEPA in Indian Country : compliance requirement to decision-making tool / Dean B. Suagee -- A framework to assess environmental justice concerns for proposed federal projects / Jan Buhrmann -- Protecting natural resources and the issue of environmental justice / Barry E. Hill, Nicholas Targ -- Mineral development : protecting the land and communities / Kathryn M. Mutz -- CONCLUSION: Hoping against history : environmental justice in the twenty-first century / Patricia Nelson Limerickhttps://scholar.law.colorado.edu/books_reports_studies/1133/thumbnail.jp

Anxiety disorders and age-related changes in physiology

Background Anxiety disorders are leading contributors to the global disease burden, highly prevalent across the lifespan and associated with substantially increased morbidity and early mortality. Aims The aim of this study was to examine age-related changes across a wide range of physiological measures in middle-aged and older adults with a lifetime history of anxiety disorders compared with healthy controls. Method The UK Biobank study recruited >500 000 adults, aged 37-73, between 2006 and 2010. We used generalised additive models to estimate non-linear associations between age and hand-grip strength, cardiovascular function, body composition, lung function and heel bone mineral density in a case group and in a control group. Results The main data-set included 332 078 adults (mean age 56.37 years; 52.65% women). In both genders, individuals with anxiety disorders had a lower hand-grip strength and lower blood pressure, whereas their pulse rate and body composition measures were higher than in the healthy control group. Case-control group differences were larger when considering individuals with chronic and/or severe anxiety disorders, and differences in body composition were modulated by depression comorbidity status. Differences in age-related physiological changes between females in the anxiety disorder case group and healthy controls were most evident for blood pressure, pulse rate and body composition, whereas this was the case in males for hand-grip strength, blood pressure and body composition. Most differences in physiological measures between the case and control groups decreased with increasing age. Conclusions Findings in individuals with a lifetime history of anxiety disorders differed from a healthy control group across multiple physiological measures, with some evidence of case-control group differences by age. The differences observed varied by chronicity/severity and depression comorbidity

El Malpais Area: National Monument, National Conservation Area and the West Malpais and Cebolla Wilderness Areas

53 p. : ill., mapshttps://scholar.law.colorado.edu/books_reports_studies/1016/thumbnail.jp

El Malpais Area: National Monument, National Conservation Area and the West Malpais and Cebolla Wilderness Areas

53 p. : ill., mapshttps://scholar.law.colorado.edu/books_reports_studies/1016/thumbnail.jp

Snake River Birds of Prey National Conservation Area Case Study

34, A-5, B-2 p. : ill., maphttps://scholar.law.colorado.edu/books_reports_studies/1023/thumbnail.jp

Potent Adjuvanticity of a Pure TLR7-Agonistic Imidazoquinoline Dendrimer

Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunity and can be exploited as powerful vaccine adjuvants for eliciting both primary and anamnestic immune responses. TLR7 agonists are highly immunostimulatory without inducing dominant proinflammatory cytokine responses. We synthesized a dendrimeric molecule bearing six units of a potent TLR7/TLR8 dual-agonistic imidazoquinoline to explore if multimerization of TLR7/8 would result in altered activity profiles. A complete loss of TLR8-stimulatory activity with selective retention of the TLR7-agonistic activity was observed in the dendrimer. This was reflected by a complete absence of TLR8-driven proinflammatory cytokine and interferon (IFN)-γ induction in human PBMCs, with preservation of TLR7-driven IFN-α induction. The dendrimer was found to be superior to the imidazoquinoline monomer in inducing high titers of high-affinity antibodies to bovine α-lactalbumin. Additionally, epitope mapping experiments showed that the dendrimer induced immunoreactivity to more contiguous peptide epitopes along the amino acid sequence of the model antigen.This work was supported by National Institutes of Health/National Institute of Allergy and Infectious Diseases contract HHSN272200900033C