The effect of a foul release coating on propeller performance

With the imminent ban on the application of coatings of TBT self-polishing co-polymers in January 2003 and their eventual prohibition in 2008 a great deal of research is being conducted into the performance of the possible alternatives. As part of the ongoing work investigating the hydrodynamic performance of foul release systems, being carried out at the University of Newcastle upon Tyne, a study into the possible benefits of their use on propellers has been conducted. The benefits that this method of propeller protection offers are potential fuel savings from increased propulsive efficiency as well as lower maintenance costs and a cleaner environment. Initially a literature review exploring the effect of propeller surface conditions on ship performance and previous work on propeller coatings for merchant ships was conducted. Theoretical calculations on the possible gains were then explored for a merchant ship propeller type using a propeller lifting surface analysis program. These showed that the significant losses in efficiency caused by blade roughening can be avoided by the application of a foul release coating with a surface finish equivalent to a new or well polished propeller

In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system

A new bespoke semi-continuous parallel column supercritical fluid chromatography unit has been developed that solves the problem of effective separation of continuous, multicomponent reaction mixtures.The authors gratefully acknowledge financial support from the Woolf Fisher Trust (DEF), EPSRC (SVL, RM; grant codes EP/K009494/1, EP/K039520/1 and EP/M004120/1) and ECH2020 (DEF, SVL; Future & Emerging Technologies (FET), “OneFlow”, sponsor reference 737266)

Persistent oseltamivir-resistant pandemic influenza A/H1N1 infection in an adult with cystic fibrosis.

The authors report the case of a 25-year-old patient with cystic fibrosis (CF) who developed pandemic influenza A/H1N1 during a visit to the USA in August 2010. The patient has severe CF lung disease and takes maintenance oral corticosteroids. The influenza virus was positive for the H275Y oseltamivir-resistance mutation despite the patient never having received oseltamivir. The patient has remained sputum-positive for over 4 months despite inhaled zanamivir therapy. This is the first reported case of transmission of oseltamivir-resistant H1N1 influenza to a patient with CF. The frequency of prolonged sputum carriage of pandemic influenza and transmission of oseltamivir-resistant strains are unknown on a population level. However, if our observations are replicated in other CF patients, they are potentially of considerable importance to clinical and infection-control practices in this patient group

Investigations into the manzamine alkaloid biosynthetic hypothesis

The biomimetic synthesis of a pentacyclic alkaloid (keramaphidin B, 1), an intermediate in the biogenetic pathway to the manzamine alkaloids, has been achieved. Compound 1 was formed by an intramolecular Diels-Alder reaction of macrocycle 2 in buffer followed by reduction with NaBH4. This reaction provides the first direct experimental evidence for the authors' biosynthetic hypothesis