A novel coordination network of Tb(III) with 2-hydroxy-trimesic acid showing very intense photoluminescence

Metals in Catalysis, Biomimetics & Inorganic Material

Distortion isomerism of Cu(II) chloride adducts with bis(2-benzimidazolyl)ethane. Synthesis, characterization, X-ray structures and spectroscopy of four different isomers

Metals in Catalysis, Biomimetics & Inorganic Material

Synthesis, crystal structure and spectroscopy of catena-poly-bis(azido-N1,N1)(2-Aminopyrimidine)Copper(II)

The compound [Cu(ampym)(l1,1-N3)2]n (ampym = 2-aminopyrimidine) has been synthesized and characterized by X-ray crystallography and infrared spectroscopy. In addition, Ligand Field and powder EPR measurements have been performed. The structure is solved in space group P21/c with a = 7.303(2), b = 19.716(4), c = 5.949(1) A˚ , b = 98.17(3), V = 847.9(3) A˚ 3 , Z = 2 with final R = 0.0382. The coordination geometry around the Cu(II) ion is distorted square pyramidal, with four nitrogen atoms of four bridging azido anions in the basal plane with Cu–N distances that range from 1.998(3) to 2.069(3) A˚ . The apical position is occupied by a nitrogen atom of the ampym molecule at a Cu–N distance of 2.169(3) A˚ . The trans-basal angles are 165.7(1) and 143.9(1). Weak hydrogen bonding is observed between the two amine hydrogen atoms and nitrogen of an azide anion and the pyrimidine-ring nitrogen atom of a neighbouring molecule (NN distances 3.174(5), 3.106(4) A˚ ). These last hydrogen bonds (N7N3) are forming so-called ‘‘WatsonCrick type’’ hydrogen bonds. In the infrared the vibrations of the coordinated azide anion are observed at 2,062, 1,273 and 655 cm-1 , while the Cu–N vibrations are observed at 370 and 224 cm-1 . Ligand-field and EPR spectra are uneventful and give spectral parameters expected in the range for such Cu(II) compounds. Magnetic susceptibility measurements reveal a weak antiferromagnetic interaction between the Cu(II) ions.Metals in Catalysis, Biomimetics & Inorganic Material

Cu(II) Compounds with Pyrimidine-Based Chelating Ligands, Bridged by a Flexible Alkyl Spacer: Synthesis, Characterisation and X-Ray Structures of Methoxide-Bridged Dinuclear-Based Species

Metals in Catalysis, Biomimetics & Inorganic Material

Red and Blue Compounds Formed from Copper(II) Bromide and the Ligand 7-Isobutyl-5-methyl-[1,2,4]triazolo [1,5-a]pyrimidine: Synthesis, Spectroscopy and Single-Crystal Structures

Metals in Catalysis, Biomimetics & Inorganic Material

Distortion Isomerism of Cu(II) Chloride Adducts with Bis(2-benzimidazolyl)ethane. Synthesis, Characterization, X-ray Structures and Spectroscopy of Four Different Isomers

Metals in Catalysis, Biomimetics & Inorganic Material

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

Background: Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two principal components derived from them. Methods: The study was conducted among participants from the Erasmus Rucphen Family Study (ERF), a Dutch family-based sample from the southwestern Netherlands. Variance components linkage analyses were performed using Merlin. Regions of interest (LOD > 1.9) were fine-mapped using microarray and exome sequence data. Results: We observed one significant LOD score for the second principal component on chromosome 15 (LOD score = 3.01) and 12 suggestive LOD scores. Several loci contained variants identified in GWAS for these traits; however, these did not explain the linkage peaks, nor did other common variants. Exome sequence data identified two associated variants after multiple testing corrections were applied. Conclusions: We did not find common SNPs explaining these linkage signals. Exome sequencing uncovered a relatively rare variant in MAPK3K11 on chromosome 11 (MAF = 0.01) that helped account for the suggestive linkage peak observed for the first principal component. Conditional analysis revealed a drop in LOD from 2.01 to 0.88 for MAP3K11, suggesting that this variant may partially explain the linkage signal at this chromosomal location. MAP3K11 is related to the JNK pathway and is a pro-apoptotic kinase that plays an important role in the induction of cardiomyocyte apoptosis in various pathologies, including LVH