Pliocene crustal shortening on the Tyrrhenian side of the northern Apennines: evidence from the Gavorrano antiform (southern Tuscany, Italy)

The northern Tyrrhenian Sea and the inner northern Apennines are classically regarded as a late Miocene–Pleistocene back-arc system developed as a consequence of slab rollback along active subduction zones. We present new geological and structural data on the Gavorrano antiform, a key sector of the inner northern Apennines. Lying close to the northern Tyrrhenian Sea, it provides clear evidence of Pliocene shortening deformation and magma emplacement. The orientation of 1 (N50°E–N80°E) derived by fault slip data inversion is consistent with a general ENE–WSW shortening direction. Furthermore, this ENE–WSW-trending orientation of 1 is compatible with the compressive deformation recorded in coeval sedimentary basins. On this basis we suggest that the inner northern Apennines were affected by crustal shortening during the Pliocene. This scenario matches well geophysical data suggesting that since the Late Messinian (6–5 Ma) subduction rollback and back-arc extension strongly decreased in the northern Tyrrhenian Sea, whereas they continued as active processes in the southern Tyrrhenian Sea

PACAP and VIP Mitigate Rotenone-Induced Inflammation in BV-2 Microglial Cells.

Rotenone is a commercial pesticide commonly used to model Parkinson's disease (PD) due to its ability to induce dopaminergic degeneration. Studies have confirmed that rotenone causes microglial activation, which seems to contribute to the toxic effects seen in rodent models. Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two structurally related neuropeptides that have robust neuroprotective and anti-inflammatory properties. However, their ability to regulate microglial activity in response to rotenone is not fully understood. Using rotenone as an inflammatory stimulus, we tested whether PACAP or VIP could mitigate microglial activation in BV2 microglial cells. Rotenone dose-dependently reduced cell viability and the percentage of apoptotic cells. It also increased the release of nitric oxide (NO) in culture media and the expression of microglial activation markers and pro-inflammatory markers, including CD11b, MMP-9 and IL-6, and heightened the endogenous levels of PACAP and its preferring receptor PAC1. Co-treatment with PACAP or VIP prevented rotenone-induced increase of NO, CD11b, MMP-9 and IL-6. These results indicate that both PACAP and VIP are able to prevent the pro-inflammatory effects of rotenone in BV2 cells, supporting the idea that these molecules can have therapeutic value in slowing down PD progression

Pliocene crustal shorthening on the Tyrrhenian side of the northern Apennones: evidence from the Gavorrano antiform (southern Tuscany, Italy)

The northern Tyrrhenian Sea and the inner northern Apennines are classically regarded as a late Miocene-Pleistocene back-arc system developed as a consequence of slab roll-back along active subduction zones. We present new geological and structural data on the Gavorrano antiform, a key sector of the inner northern Apennines. Lying close to the northern Tyrrhenian Sea, it provides clear evidence of Pliocene shortening deformation and magma emplacement. The orientation of σ1 (N50°E - N80°E) derived by fault slip data inversion is consistent with a general ENE –WSW shortening direction. Furthermore, this ENE-trending orientation of σ1 is compatible with the compressive deformation recorded in coeval sedimentary basins. On this basis we suggest that the inner northern Apennines were affected by crustal shortening during the Pliocene. This scenario matches well geophysical data suggesting that since the Late Messinian (6 – 5 Ma) subduction rollback and back-arc extension strongly decreased in the northern Tyrrhenian Sea, while they continued as active processes in the southern Tyrrhenian Sea

Expanded Endoscopic Approach for Anterior Skull Base Tumors: Experience of a Multidisciplinary Skull Base Team

Abstract: The aim of this study is to describe the experience of a multidisciplinary skull base team with transnasal endoscopic surgery for anterior cranial base tumors. A retrospective chart review was conducted on patients who underwent an exclusive expanded transnasal approach to the anterior skull base in the period from December 2014 to November 2015. Data on patient demographics, tumor characteristics, surgical information, imaging, and postoperative complications were collected and analyzed. From a total of 120 patients with skull base diseases managed by the skull base team, 36 were admitted to this study. The overall complication rate in this series was 16.7%, gross total resection was achieved in 32 cases (88.9%) and postoperative CSF leakage occurred in 5 cases (13.9%). Our preliminary results confirm that an exclusive endoscopic transnasal approach to the anterior cranial base

Physical activity levels and related energy expenditure during COVID-19 quarantine among the sicilian active population: A cross-sectional online survey study

Background: During the coronavirus disease 2019 (COVID-19) pandemic, the Italian government has adopted containment measures to control the virus's spread, including limitations to the practice of physical activity (PA). The aim of this study was to estimate the levels of PA, expressed as energy expenditure (MET-minute/week), among the physically active Sicilian population before and during the last seven days of the COVID-19 quarantine. Furthermore, the relation between this parameter and specific demographic and anthropometric variables was analyzed. Methods: 802 Sicilian physically active participants (mean age: 32.27 ± 12.81 years; BMI: 23.44 ± 3.33 kg/m2) were included in the study and grouped based on gender, age and BMI. An adapted version of the International Physical Activity Questionnaire-short form (IPAQ-SF) was administered to the participants through an online survey. The Wilcoxon signed-rank test and the Kruskal-Wallis rank-sum test were used for statistical analyses. Results: As expected, we observed a significant decrease of the total weekly energy expenditure during the COVID-19 quarantine (p < 0.001). A significant variation in the MET-min/wk in the before quarantine condition (p = 0.046) and in the difference between before and during quarantine (p = 0.009) was found for males and females. The male group decreased the PA level more than the female one. Moreover, a significant difference in the MET-min/wk was found among groups distributions of BMI (p < 0.001, during quarantine) and of age (p < 0.001, both before and during quarantine). In particular, the highest and the lowest levels of PA were reported by the young and the elderly, respectively, both before and during quarantine. Finally, the overweight group showed the lowest level of PA during quarantine. Conclusion: Based on our outcomes, we can determine that the current quarantine has negatively affected the practice of PA, with greater impacts among males and overweight subjects. In regards to different age groups, the young, young adults and adults were more affected than senior adults and the elderly

Tackling dipeptidyl peptidase IV in neurological disorders

© 2018, Medknow Publications. All rights reserved. Dipeptidyl peptidase IV (DPP-IV) is a serine protease best known for its role in inactivating glucagon-like peptide-1 (GLP-1), pituitary adenylate cyclase-activating polypeptide (PACAP) and glucose-dependent insulinotropic peptide (GIP), three stimulators of pancreatic insulin secretion with beneficial effects on glucose disposal. Owing to the relationship between DPP-IV and these peptides, inhibition of DPP-IV enzyme activity is considered as an attractive treatment option for diabetic patients. Nonetheless, increasing studies support the idea that DPP-IV might also be involved in the development of neurological disorders with a neuroinflammatory component, potentially through its non-incretin activities on immune cells. In this review article, we aim at highlighting recent literature describing the therapeutic value of DPP-IV inhibitors for the treatment of such neurological conditions. Finally, we will illustrate some of the promising results obtained using berberine, a plant extract with potent inhibitory activity on DPP-IV

Geology of the Northern Apennines nappe stack on eastern Elba (Italy): new insights on the Neogene orogenic evolution of the Northern Tyrrhenian Sea

We document the tectonic and metamorphic evolution of thrust nappes of the eastern island of Elba. The area exposes a natural cross section of the Northern Apennines hinterland, from the metamorphic basement units to the overlying continent- and ocean-derived nappes. We integrated mapping, analysis of structures and microstructures, and the interpretation of drill core logs with lithostratigraphic, metamorphic, and geochronological constraints, producing a novel geological map of eastern Elba (1:5’000 scale). We show that the area experienced polyphase Oligocene–Pliocene contractional tectonics marked by in-sequence and out-of-sequence thrusting accompanied by folding and overprinted by faulting in the Pliocene. Magmatism occurred during contraction with post-magmatic thrusting ultimately coupling HP-LT and LP-HT units. Drill core logs allow for the first time the reconstruction of the N-dipping character of the Zuccale Fault, which represents the youngest (late Miocene–early Pliocene) large-scale structure in the area

A correlation between intestinal microbiota dysbiosis and osteoarthritis

© 2019 Osteoarthritis (OA) is a degenerative disease of the articular cartilage, resulting in pain and total joint disability. Recent studies focused on the role of the metabolic syndrome in inducing or worsening joint damage suggest that chronic low-grade systemic inflammation may represent a possible linking factor. This finding supports the concept of a new phenotype of OA, a metabolic OA. The gut microbiome is fundamental for human physiology and immune system development, among the other important functions. Manipulation of the gut microbiome is considered an important topic for the individual health in different medical fields such as medical biology, nutrition, sports, preventive and rehabilitative medicine. Since intestinal microbiota dysbiosis is strongly associated with the pathogenesis of several metabolic and inflammatory diseases, it is conceivable that also the pathogenesis of OA might be related to it. However, the mechanisms and the contribution of intestinal microbiota metabolites in OA pathogenesis are still not clear. The aim of this narrative review is to review recent literature concerning the possible contribution of dysbiosis to OA onset and to discuss the importance of gut microbiome homeostasis maintenance for optimal general health preservation