Tapering Enhanced Stimulated Superradiant Oscillator

In this paper, we present a new kind of high power and high efficiency free-electron laser oscillator based on the application of the tapering enhanced stimulated superradiant amplification (TESSA) scheme. The main characteristic of the TESSA scheme is a high intensity seed pulse which provides high gradient beam deceleration and efficient energy extraction. In the oscillator configuration, the TESSA undulator is driven by a high repetition rate electron beam and embedded in an optical cavity. A beam-splitter is used for outcoupling a fraction of the amplified power and recirculate the remainder as the intense seed for the next electron beam pulse. The mirrors in the oscillator cavity refocus the seed at the undulator entrance and monochromatize the radiation. In this paper we discuss the optimization of the system for a technologically relevant example at 1 $\mu$m using a 1~MHz repetition rate electron linac starting with an externally injected igniter pulse.Comment: 24 pages, 13 figure

Power consumption evaluation of circuit-switched versus packet-switched optical backbone networks

While telecommunication networks have historically been dominated by a circuit-switched paradigm, the last decades have seen a clear trend towards packet-switched networks. In this paper we evaluate how both paradigms perform in optical backbone networks from a power consumption point of view, and whether the general agreement of circuit switching being more power-efficient holds. We consider artificially generated topologies of various sizes, mesh degrees and not yet previously explored in this context transport linerates. We cross-validate our findings with a number of realistic topologies. Our results show that, as a generalization, packet switching can become preferable when the traffic demands are lower than half the transport linerate. We find that an increase in the network node count does not consistently increase the energy savings of circuit switching over packet switching, but is heavily influenced by the mesh degree and (to a minor extent) by the average link length

PACAP and VIP Mitigate Rotenone-Induced Inflammation in BV-2 Microglial Cells.

Rotenone is a commercial pesticide commonly used to model Parkinson's disease (PD) due to its ability to induce dopaminergic degeneration. Studies have confirmed that rotenone causes microglial activation, which seems to contribute to the toxic effects seen in rodent models. Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two structurally related neuropeptides that have robust neuroprotective and anti-inflammatory properties. However, their ability to regulate microglial activity in response to rotenone is not fully understood. Using rotenone as an inflammatory stimulus, we tested whether PACAP or VIP could mitigate microglial activation in BV2 microglial cells. Rotenone dose-dependently reduced cell viability and the percentage of apoptotic cells. It also increased the release of nitric oxide (NO) in culture media and the expression of microglial activation markers and pro-inflammatory markers, including CD11b, MMP-9 and IL-6, and heightened the endogenous levels of PACAP and its preferring receptor PAC1. Co-treatment with PACAP or VIP prevented rotenone-induced increase of NO, CD11b, MMP-9 and IL-6. These results indicate that both PACAP and VIP are able to prevent the pro-inflammatory effects of rotenone in BV2 cells, supporting the idea that these molecules can have therapeutic value in slowing down PD progression

Progress on the hybrid gun project at UCLA

UCLA/INFN-LNF/Univ. Rome has been developing the hybrid gun which has an RF gun and a short linac for velocity bunching in one structure. After the cavity was manufactured at INFN-LNF in 2012, tests of the gun was carried out at UCLA. The field in the standing wave part was 20 % smaller than the simulation but the phase advance was fine. The cavity was commissioned successfully up to 13 MW. The beam test was performed at 11.5 MW and demonstrated the bunch compression

A correlation between intestinal microbiota dysbiosis and osteoarthritis

© 2019 Osteoarthritis (OA) is a degenerative disease of the articular cartilage, resulting in pain and total joint disability. Recent studies focused on the role of the metabolic syndrome in inducing or worsening joint damage suggest that chronic low-grade systemic inflammation may represent a possible linking factor. This finding supports the concept of a new phenotype of OA, a metabolic OA. The gut microbiome is fundamental for human physiology and immune system development, among the other important functions. Manipulation of the gut microbiome is considered an important topic for the individual health in different medical fields such as medical biology, nutrition, sports, preventive and rehabilitative medicine. Since intestinal microbiota dysbiosis is strongly associated with the pathogenesis of several metabolic and inflammatory diseases, it is conceivable that also the pathogenesis of OA might be related to it. However, the mechanisms and the contribution of intestinal microbiota metabolites in OA pathogenesis are still not clear. The aim of this narrative review is to review recent literature concerning the possible contribution of dysbiosis to OA onset and to discuss the importance of gut microbiome homeostasis maintenance for optimal general health preservation