4 research outputs found
Assessment of Osteointegration of Cortoss (TM) in Cranioplasty: An Experimental Study in Rabbits
WOS: 000318549800016Objectives: Calvarial defects must be closed for either cosmetic reasons or for protection of the calvarial contents. We aimed to assess whether Cortoss (TM), a biocompatible synthetic cortical bone void filler, can provide satisfactory osteointegration in cranial defects. Methods: Twenty New Zealand white adult rabbits were divided into 4 groups: craniectomy (n = 6), cranioplasty (n = 6), sham (n = 6) and control (n = 2) groups. Treatment for each group was as follows: craniectomy group had calvarial defects that were left empty; the cranioplasty group the defects were reconstructed with Cortoss (TM); the sham group had only a skin incision and no defect; and in the control group no surgery was performed. All the animals were sacrificed 6 months after the procedures and the materials were examined histopathologically and radiologically in order to assess osteointegration of Cortoss (TM). Results: Radiological examination demonstrated almost complete apposition of the bone to Cortoss (TM) without any defect or sutures and the cosmetic outcomes were satisfactory. Radiological findings were supported by the histopathologic examinations which revealed that osteointegration had been completed without any fibrous band formation surrounding the Cortoss (TM) implant. Conclusion: Cortoss (TM) leads to significant osteointegration at 24 weeks in rabbit calvarial defects. The results of this in vivo study suggest that Cortoss (TM) may be considered a safe and effective material for the reconstruction of calvarial defects
Two cases of arachnoid cyst complicated by spontaneous intracystic hemorrhage
Arachnoid cysts are developmental anomalies which are usually
asymptomatic. Intracystic hemorrhage after trauma is a well known
complication; however, spontaneous intracystic hemorrhage is rare. This
report presents two rare cases of arachnoid cyst complicated by
spontaneous intracystic hemorrhage. The first patient was admitted
following transient loss of consciousness and speech disturbance, and a
subacute subdural hematoma at the left temporal region was diagnosed.
The second patient presented with severe headache of four days duration
and a subdural hematoma at the left temporoparietal region was
diagnosed. In both the patients, both on radiological examination and
during surgical intervention, hematomas were found to be intracystic
Kranioplastide Cortoss™'un Osteointegrasyonunun Değerlendirilmesi: Tavşanlarda Bir Deneysel Çalışma
Amaç: Kalvariyal defektler kozmetik nedenlerle veya kalvariyal içeriğin korunması amacıyla kapatılmalıdır. Bu çalışmada bir biyouyumlu sentetik kemik doldurucu olan Cortoss™'un kranial defektlerde yeterli osteointegrasyon sağlayıp sağlayamadığını incelemeyi amaçladık. Materyal ve Metod: Yirmi Yeni Zellanda beyaz erişkin tavşan 4 gruba ayrıldı: kraniektomi (n = 6), kranioplasti (n = 6), sham (n = 6) ve kontrol (n = 2) grupları. Kraniektomi grubunda kalvarial defekt oluşturulup kapatılmadı. Kranioplasti grubunda defektler Cortoss™ ile tamir edildi. Sham grubunda sadece cilt insizyonu yapıldı ve defekt oluşturulmadı. Kontrol grubuna ise cerrahi bir işlem uygulanmadı. Bütün hayvanlar cerrahi işlemden 6 ay sonra sakrifiye edildi ve materyaller Cortoss™'un osteointegrasyonunun değerlendirilmesi amacıyla histopatolojik ve radyolojik olarak incelendi. Bulgular: Radyolojik incelemelerde Cortoss™ ile kemik kaynaşmasının arada defekt kalmaksızın tam olduğu ve kozmetik sonuçların da yeterli olduğu görüldü. Radyolojik bulguları destekleyen şekilde Cortoss™ implantı etrafında herhangi bir fibröz bant olmaksızın tam osteointegrasyonu gösteren histopatolojik inceleme sonuçları elde edildi. Sonuç: Tavşan kalvarial defektlerinin tamirinde Cortoss™ 24. haftada belirgin osteointegrasyon sağlamaktadır. Bu in vivo çalışmanın sonuçları Cortoss™'un kalvarial defekt rekonstrüksyonunda kullanımının güvenli ve etkili olduğunu desteklemektedir.Objectives: Calvarial defects must be closed for either cosmetic reasons or for protection of the calvarial contents. We aimed to assess whether Cortoss™, a biocompatible synthetic cortical bone void filler, can provide satisfactory osteointegration in cranial defects. Methods: Twenty New Zealand white adult rabbits were divided into 4 groups: craniectomy (n = 6), cranioplasty (n = 6), sham (n = 6) and control (n = 2) groups. Treatment for each group was as follows: craniectomy group had calvarial defects that were left empty; the cranioplasty group the defects were reconstructed with Cortoss™; the sham group had only a skin incision and no defect; and in the control group no surgery was performed. All the animals were sacrificed 6 months after the procedures and the materials were examined histopathologically and radiologically in order to assess osteointegration of Cortoss™. Results: Radiological examination demonstrated almost complete apposition of the bone to Cortoss™ without any defect or sutures and the cosmetic outcomes were satisfactory. Radiological findings were supported by the histopathologic examinations which revealed that osteointegration had been completed without any fibrous band formation surrounding the Cortoss™ implant. Conclusion: Cortoss™ leads to significant osteointegration at 24 weeks in rabbit calvarial defects. The results of this in vivo study suggest that Cortoss™ may be considered a safe and effective material for the reconstruction of calvarial defects
Assessment of Osteointegration of Cortoss (TM) in Cranioplasty: An Experimental Study in Rabbits
Objectives: Calvarial defects must be closed for either cosmetic reasons or for protection of the calvarial contents. We aimed to assess whether Cortoss (TM), a biocompatible synthetic cortical bone void filler, can provide satisfactory osteointegration in cranial defects