A new perspective to determine the severity of cases with Crimean-Congo hemorrhagic fever

Background & objectives: We have established a severity grading score (SGS) system for predicting the fatalityin Crimean-Congo hemorrhagic fever (CCHF) for the first time.Methods: This SGS has been set up by using several variables which were assumed to be associated withmortality according to the literature and also were considered to have clinical importance.Results: In all, 237 patients who had symptoms of CCHF for 11 means high risk for mortality (67%)and six out of 9 patients in this group died (p = 0.001). The sensitivity, specificity, accuracy, positive predictivevalue, and negative predictive value for >11 points of SGS were 67, 100, 98, 100, and 98%, respectively.Conclusions: This scoring system may help the clinicians to decide which patient to refer to a tertiary stephospital which may also decrease the cost and improve the functionality of healthcare staff

Evidence of vascular endothelial damage in Crimean-Congo hemorrhagic fever

Background: Endothelial infection has an important role in the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF). In this study, we investigated the causes of vascular endothelial damage in patients with CCHF

Evidence of vascular endothelial damage in Crimean-Congo hemorrhagic fever

Background: Endothelial infection has an important role in the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF). In this study, we investigated the causes of vascular endothelial damage in patients with CCHF

Elevated chemokine levels during adult but not pediatric crimean-congo hemorrhagic fever

Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis. Clinical reports indicate the severity of CCHF is milder in children than adults. The chemokines are important chemo-attractant mediators of the host immune system. Objectives: The main aim of the study was to identify whether or not there were any differences in chemokine levels between the pediatric and adult patients and control groups, and whether there was any correlation with disease severity. Study design: The serum levels of select chemokines including chemokine (C-C) ligand 2 (CCL2), CCL3, CCL4, chemokine (C-X-C) ligand 8 (CXCL8), CXCL9, and granulocyte-colony stimulating factor (G-CSF) in 29 adult and 32 pediatric CCHF patients and in 35 healthy children and 40 healthy adult control groups were studied by flow cytometric bead immunoassay method. Results: Great variability was detected in the serum levels of the chemokines for both the adult and pediatric patients and controls. With the exception of G-CSF, the median serum levels of CCL2, CCL3, CCL4, CXCL8, and CXCL9 were found to be significantly higher in the adult patients compared to adult controls (2364.7 vs. 761. pg/ml; 714.1 vs. 75.2. pg/ml; 88.6 vs. 25.5. pg/ml; 217.9 vs. 18.3. pg/ml; 875 vs. 352.2. pg/ml, respectively, p<. 0.0001 for all comparisons). Among the chemokines the median CCL4 and G-CSF levels were significantly higher in the pediatric patients compared to pediatric controls (40.3 vs. 7.1. pg/ml, p<. 0.0001; 0.1 vs. 0.1. pg/ml, p= 0.049, respectively). Conclusion: The results of this study showed prominent chemokine raising in adult CCHF patients compared to children CCHF patients

Mortality predictors of Staphylococcus aureus bacteremia: a prospective multicenter study

Background: Staphylococcus aureus is one of the causes of both community and healthcare-associated bacteremia. The attributable mortality of S. aureus bacteremia (SAB) is still higher and predictors for mortality and clinical outcomes of this condition are need to be clarified. In this prospective observational study, we aimed to examine the predictive factors for mortality in patients with SAB in eight Turkish tertiary care hospitals