24 research outputs found

    The burden of clostridium difficile infection in patients with liver cirrhosis

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    Clostridium Difficile Infection (CDI) has registered a dramatically increasing incidence in the general population over the past decades. Nowadays, Clostridium Difficile is the leading cause of hospital-acquired diarrhea in Europe and North America. Liver cirrhosis is the final stage of any chronic liver disease (CLD). The most common causes are chronic hepatitis C or B and viral co-infections, alcohol misuse, and nonalcoholic fatty liver disease (NAFLD). CLD and cirrhosis are listed among the ten leading causes of death in the US. Cirrhosis due to any etiology disrupts the homeostatic role of the liver in the body. Cirrhosis-associated immune dysfunction (CAID) leads to alterations in both inherited and acquired systemic and local liver immunity. CAID is caused by increased systemic inflammation and immunodeficiency and it is responsible for 30% of mortality rates all over the world. Clostridium Difficile infection frequently affects patients suffering from liver cirrhosis because of the high number of prolonged hospitalizations, regular use of antibiotics for the prevention or treatment of SBP, proton pump inhibitor (PPI) use, and an overall immunocompromised state. Clostridium Difficile is a Gram-positive bacterium responsible for the high morbidity and mortality rates in patients with cirrhosis, with an essential increase in a 30-day mortality

    Druid, event display for the linear collider

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    Druid is a dedicated event display designed for the future electron positron linear colliders. Druid takes standard linear collider data files and detector geometry description files as input, it can visualize both physics event and detector geometry. Many displaying options are provided by Druid, giving easy access to different information. As a versatile event display, Druid supports all the latest linear collider detector models, Silicon Detector and International Large Detector, as well as the calorimeter prototypes operated in the CALICE test beam experiments. It has been utilized in many studies such as the verification of detector geometry, analysis of the simulated full events and test beam data as well as reconstruction algorithm development and code debugging

    The burden of clostridium difficile infection in patients with liver cirrhosis

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    Clostridium Difficile Infection (CDI) has registered a dramatically increasing incidence in the general population over the past decades. Nowadays, Clostridium Difficile is the leading cause of hospital-acquired diarrhea in Europe and North America. Liver cirrhosis is the final stage of any chronic liver disease (CLD). The most common causes are chronic hepatitis C or B and viral co-infections, alcohol misuse, and nonalcoholic fatty liver disease (NAFLD). CLD and cirrhosis are listed among the ten leading causes of death in the US. Cirrhosis due to any etiology disrupts the homeostatic role of the liver in the body. Cirrhosis-associated immune dysfunction (CAID) leads to alterations in both inherited and acquired systemic and local liver immunity. CAID is caused by increased systemic inflammation and immunodeficiency and it is responsible for 30% of mortality rates all over the world. Clostridium Difficile infection frequently affects patients suffering from liver cirrhosis because of the high number of prolonged hospitalizations, regular use of antibiotics for the prevention or treatment of SBP, proton pump inhibitor (PPI) use, and an overall immunocompromised state. Clostridium Difficile is a Gram-positive bacterium responsible for the high morbidity and mortality rates in patients with cirrhosis, with an essential increase in a 30-day mortality

    The experience of Romanian physiotherapists in the management of postoperative rehabilitation of patients with total hip arthroplasty - content and criteria for completion of physiotherapy sessions

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    Background: Total hip arthroplasty (THA) is a procedure that removes damaged bone and car-tilage and replaces it with prosthetic components and is performed by orthopedics. Objective: management of post-operative rehabilitation of THA patients in terms of content and comple-tion criteria of physiotherapy sessions. The research aims to explore the experience of Romani-an physiotherapists about the content and completion criteria of physiotherapy sessions in-volved in the management of postoperative rehabilitation after THA. Methods: The method used in this study was a questionnaire-based survey, with 120 Romanian specialists in the field completing an online screening tool that contained, along with a socio-demographic question-naire, a series of questions about their professional experience. Results: One of the most im-portant results of the study is the identification of statistically significant associations between the completion criteria of physiotherapy sessions and three techniques included in the rehabil-itation program after THA: edema management, gait re-education exercises, and exercises to increase hip mobility. Conclusion: The the research revealed that the experience of Romanian specialists regarding postoperative rehabilitation after THA is concordant with the experience of specialists in the field, and can be used to develop and test an individualized therapeutic protocol and to design continuing professional training programs for physiotherapists in Romania

    Scoliotic postural alignment in prepubertal children: somatoscopic analysis of anatomical landmarks and development of a working model to limit spinal changes

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    Background. The study aims to perform a somatoscopic analysis on a sample of 100 prepubertal children aged 10-14 years, girls and boys, who are diagnosed with scoliosis. Somatoscopic as-sessment is one of the most commonly used, therefore we thought that making a way of inter-preting the results could be useful to monitor postural attitude in children diagnosed with sco-liosis. Identifying the early onset of physical impairment in the spine with somatoscopy can be a key factor in maintaining optimal postural status. This approach may help in achieving a way of working that limits the negative effects of scoliosis on the subjects. Materials and methods. The selection of subjects is based on exclusion and inclusion criteria related to age, comorbidi-ties, therapeutic approach, and other criteria. Also, aspects that accompany the growth and de-velopment process of children in this prepubertal period and factors that may disturb this pro-cess are described in detail. Also in this context, we will present basic notions of body posture and etiopathogenesis of the onset of scoliotic deficiencies in children during this period of growth and development. Somatoscopic analysis is performed in the orthostatic position and is based on the identification of anatomical landmarks of the body concerning body posture. Re-sults. From the total analyzed scoliosis, n = 100, 74% are type „C” scoliosis and only 26% are type „S” and in terms of gender, 59% are girls and 41% boys; type „C1” (Cobb angle <100) scoliosis n = 60, with an angulation < 100 are 43.24% stabilized, therefore type „C1” scoliosis are more likely to be stabilized. „S”-type scoliosis with an angulation < 150 is only 3 cases repre-senting 11.53%, and those with an angulation from < 200 to < 400 are number 23 cases 88.64% which concludes that „S” type scoliosis is more aggressive and more difficult to manage. Con-clusions. Our study show that only 13% of the subjects had a regression of the angulation fol-lowing the kinetotherapy program, therefore the main objective remains to stabilize the scoli-osis attitude and limit the effects of this pathology. A regular assessment and somatotopic analysis resulting in a physiotherapy exercises program containing corrective postural postures and postural education is the most beneficial approach to stabilize the postural deficit

    Pion and proton showers in the CALICE scintillator-steel analogue hadron calorimeter

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    Showers produced by positive hadrons in the highly granular CALICE scintillator-steel analogue hadron calorimeter were studied. The experimental data were collected at CERN and FNAL for single particles with initial momenta from 10 to 80 GeV/c. The calorimeter response and resolution and spatial characteristics of shower development for proton- and pion-induced showers for test beam data and simulations using Geant4 version 9.6 are compared.Comment: 26 pages, 16 figures, JINST style, changes in the author list, typos corrected, new section added, figures regrouped. Accepted for publication in JINS

    Hadron shower decomposition in the highly granular CALICE analogue hadron calorimeter

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    The spatial development of hadronic showers in the CALICE scintillator-steel analogue hadron calorimeter is studied using test beam data collected at CERN and FNAL for single positive pions and protons with initial momenta in the range from 10 to 80 GeV/c. Both longitudinal and radial development of hadron showers are parametrised with two-component functions. The parametrisation is fit to test beam data and simulations using the QGSP_BERT and FTFP_BERT physics lists from Geant4 version 9.6. The parameters extracted from data and simulated samples are compared for the two types of hadrons. The response to pions and the ratio of the non-electromagnetic to the electromagnetic calorimeter response, h/e, are estimated using the extrapolation and decomposition of the longitudinal profiles.Comment: 38 pages, 19 figures, 5 tables; author list changed; submitted to JINS
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