99 research outputs found

    Phytochemical, Pharmacological And Pharmacokinetic Studies Of Phyllanthus Niruri Linn Lignans As Potential Antihyperuricemic Agents [QK861. V694 2008 f rb].

    Get PDF
    Ekstrak metanol dari daun Phyllanthus niruri L. menunjukkan aktiviti antihiperurisemik oral yang bergantungan dos di dalam tikus hiperurisemia yang diaruh dengan kalium oksonat dan asid urik. The methanol extract from the leaves of Phyllanthus niruri L. showed dose-dependent oral antihyperuricemic activity in potassium oxonate- and uric acid-induced hyperuricemic rats. Fractionation of the extract by resin chromatography gave a less polar fraction which exhibited the highest reduction of plasma uric acid

    Comparative Analysis of Lycorine in Wild Plant and Callus Culture Samples of Hymenocallis littoralis by HPLC-UV Method

    Get PDF
    The Hymenocallis littoralis, an ornamental and medicinal plant, had been traditionally used for wound healing. In the present study, an analytical method using HPLC with ultraviolet detection was developed for the quantification of lycorine in the extracts of different parts of wild plant and tissue culture samples of H. littoralis.The separationwas achieved using a reversed-phase column. The method was found to be accurate, repeatable, and sensitive for the quantification of minute amount of lycorine present in the samples. The highest lycorine content was found in the bulb extract (2.54 ± 0.0

    EFFICACY OF CLITORIA TERNATEA LEAF EXTRACT AGAINST EXPERIMENTAL ASPERGILLOSIS

    Get PDF
    Objective: To evaluate the efficacy of methanolic extract of Clitoria ternatea leaf in experimental murine systemic aspergillosis. Methods: The investigation of methanolic extract of C. ternatea leaf against experimental murine systemic aspergillosis was assessed by the survival rates, quantitative determination of fungal burden in spleen, kidney and lung organs, histopathological evaluation and serum galactomannan index. Results: Methanolic extract of C. ternatea and amphotericin B demonstrated survival benefits over control. All untreated animals died by day 14. Similarly, both treated groups had significant reductions (P< 0.05) in the fungal burden of lungs, kidneys and spleen. By day 28, there was a complete clearance of the fungi from these organs. A decline was also observed in serum galactomannan level of treated animals. Conclusion: The methanolic extract of C. ternatea was effective against aspergillosis in immunocompromised mice comparable to that of amphotericin. This study merits further clinical investigations of this extract as well as isolation and characterization of their bioactive antifungal chemical constituent(s)

    Nuclear magnetic resonance spectroscopy based metabolomics to identify novel biomarkers of alcohol-dependence

    Get PDF
    Alcohol misuse is a ravaging public health and social problem. Its harm can affect the drinkers and the whole society. Alcohol-dependence is a phase of alcohol misuse in which the drinker consumes excessive amounts of alcohol and has a continuous urge to consume alcohol. Current methods of alcohol dependence diagnoses are questionnaires and some biomarkers. However, both methods lack specificity and sensitivity. Metabolomics is a scientific field which deals with the identification and the quantification of the metabolites present in the metabolome using spectroscopic techniques such as nuclear magnetic resonance (NMR). Metabolomics helps to indicate the perturbation in the levels of metabolites in cells and tissues due to diseases or ingestion of any substances. NMR is one of the most widely used spectroscopic techniques in metabolomics because of its reproducibility and speed. Some recent metabolomics studies were conducted on alcohol consumption and alcohol misuse in animals and humans. However, few focused on identifying alcohol dependence novel biomarkers. A sensitive and specific technique such as NMR based metabolomics applied to find novel biomarkers in plasma and urine can be useful to diagnose alcohol-dependence

    (3E,5E)-3,5-Bis(naphthalen-1-yl­methyl­idene)piperidin-4-one

    Get PDF
    In the title compound, C27H21NO, the piperidine ring adopts a chair conformation. The mean plane through the piperidine ring makes dihedral angles of 49.27 (5) and 63.07 (5)° with the naphthalene ring systems. In the crystal, mol­ecules are linked into dimers via pairs of inter­molecular C—H⋯O inter­actions, generating ten-membered R 2 2(10) ring motifs. C—H⋯π inter­actions further stabilize the crystal structure

    (E)-2-(4-Methylbenzylidene)hydrazinecarboxamide

    Get PDF
    The title compound, C9H11N3O, was synthesized by the reaction of 4-methyl­benzaldehyde with semicarbazide. The mol­ecule adopts an E configuration about the central C=N double bond and the dihedral angle between the mean planes of the benzene ring and the carboxamide groups is 17.05 (9)°. The hydrazine N atoms are twisted slightly out of the plane of the carboxamide group [C—C—N—N torsion angle = 178.39 (14)°] and an intra­molecular N—H⋯N bond generates an S(5) ring. In the crystal, adjacent mol­ecules are connected via a pair of N—H⋯O hydrogen bonds, generating R 2 2(8) loops, resulting in supra­molecular [001] ribbons

    (3E,5E)-1-Acryloyl-3,5-bis­(2,4-dichloro­benzyl­idene)piperidin-4-one hemihydrate

    Get PDF
    The asymmetric unit of the title compound, C22H15Cl4NO2·0.5H2O, consists of a (3E,5E)-1-acryloyl-3,5-bis­(2,4-dichloro­benzyl­idene)piperidin-4-one mol­ecule and a half-mol­ecule of water (the O atom of the water mol­ecule lies on a twofold axis). The piperidin-4-one ring adopts an envelope conformation. The dihedral angle between the two terminal benzene rings is 8.84 (11)°. In the crystal, mol­ecules are connected by C—H⋯O hydrogen bonds forming supra­molecular chains along the c axis. Furthermore, adjacent chains are inter­connected by the water mol­ecules via O—H⋯O hydrogen bonds

    Metabolomic Analysis of Blood and Urine to identify Alcohol-Dependence Biomarkers

    Get PDF
    The clinical diagnosis of alcohol-dependence (AD) currently relies on AD assessment questionnairesand biomarkers such as Carbohydrate-DeficientTransferrin (CDT), Gamma Glutamyl Transferase (GGT) and Phosphatidylethanol (PEth). However, both methods of diagnosis lackspecificity and sensitivity. Metabolic fingerprinting using nuclear magnetic resonance spectroscopy (NMR)of plasma may give us a novel andaccurate method for the diagnosis of the disease. Our primary objective was to identify the metabolites/biomarkers that could discriminate between subjects diagnosed asAD, social drinkersnon-dependent and healthy control
    corecore