The viability of Mercosur in the face of the Euro crisis

This research examines the successes and challenges of the European Union, especially in the face of the crisis of 2008 and 2009. Based on the current structures of the European Union and Mercosur, this paper looks to assess the viability of further integration of Mercosur using the evolution of the European Union as a model of reference. Analysis of key economic measures provides the framework for assessment, with a special focus on the asymmetries between member countries within Mercosur. Differences in debt-to-GDP ratios, regional trade levels, and exchange rate fluctuations are the primary indicators used to provide policy recommendations for the future of Mercosur. Based on high levels of inequality on the key measures considered within the paper, greater integration within Mercosur is encouraged, given improvement upon and adherence to guidelines originally set forth by the European Union

Development of Boys and Young Men of Color: Implications of Developmental Science for My Brother's Keeper Initiative

This report describes the My Brother's Keeper Initiative. The report summarizes ideas gleaned from developmental science that may be useful in efforts to reach five of the six initiative's goals: school readiness; third-grade literacy; high school and college graduation; and reduction of violence. The authors discuss features of the initiative designed to promote more positive outcomes and highlight the contributions that developmental science may make to each. Policy recommendations are provided and a discussion about how developmental science may contribute to national dialogue and policy formation

Scientific Research in Missouri

Scientific research projects, resources, and prospects of future research - economic stud

Human Therapies as a Successful Liaison between Chemistry and Biology

The development of novel therapies is arguably one of the most important roles of modern chemistry and biology. Here, we shed light on a particular class of human therapies in which synthetic chemical entities are attached to expressed biologicals (proteins) with the goal to enhance clinical activity. We focus our discussion on three key categories of these derivatized biologicals: proteins conjugated with biologically inert molecules, proteins conjugated with biologically active small molecules and peptides (e.g., antibody drug conjugates [ADCs]), and proteins conjugated with radio isotopes. Overall, it is apparent by the impact on clinical activity as well as the commercial success that chemical modification of recombinant proteins is becoming of increasing importance. Therefore, we argue that deeper understanding of the chemical reactions between large proteinaceous molecules and small molecule reagents will allow for more precise and elegant solutions to existing limitations in this field

Stone-Wales Transformation Paths in Fullerene C60

The mechanisms of formation of a metastable defect isomer of fullerene C60 due to the Stone-Wales transformation are theoretically studied. It is demonstrated that the paths of the "dynamic" Stone-Wales transformation at a high sufficient for overcoming potential barriers) temperature can differ from the two "adiabatic" transformation paths discussed in the literature. This behavior is due to the presence of a great near-flat segment of the potential-energy surface in the neighborhood of metastable states. Besides, the sequence of rupture and formation of interatomic bonds is other than that in the case of the adiabatictransformation.Comment: 10 pages, 6 figure

Parenting Practices in Diverse Family Structures: Examination of Adolescents’ Development and Adjustment

This article explored the implications of diverse family structures on adolescents’ adjustment, with an emphasis on whether and, if so, how diverse family structures influence and predict developmental outcomes. Family relationships within the family unit are a stronger predictor of adolescents’ development than the particular family structure. Transitions in families that result in notable reductions in effective parenting practices and economic well‐being will negatively affect youth, regardless of family structure. Family processes that promote optimal growth and development among youth in traditional two‐parent, heterosexual households work similarly for those growing up in nontraditional family structures. A conceptual model to advance this field of research is offered, and implications for research and policy are discussed

The Challenges of First-in-Human Stem Cell Clinical Trials: What Does This Mean for Ethics and Institutional Review Boards?

Stem cell-based clinical interventions are increasingly advancing through preclinical testing and approaching clinical trials. The complexity and diversity of these approaches, and the confusion created by unproven and untested stem cell-based "therapies," create a growing need for a more comprehensive review of these early-stage human trials to ensure they place the patients at minimal risk of adverse events but are also based on solid evidence of preclinical efficacy with a clear scientific rationale for that effect. To address this issue and supplement the independent review process, especially that of the ethics and institutional review boards who may not be experts in stem cell biology, the International Society for Stem Cell Research (ISSCR) has developed a set of practical questions to cover the major issues for which clear evidence-based answers need to be obtained before approving a stem cell-based trial

Instantaneous Normal Mode Analysis of Supercooled Water

We use the instantaneous normal mode approach to provide a description of the local curvature of the potential energy surface of a model for water. We focus on the region of the phase diagram in which the dynamics may be described by the mode-coupling theory. We find, surprisingly, that the diffusion constant depends mainly on the fraction of directions in configuration space connecting different local minima, supporting the conjecture that the dynamics are controlled by the geometric properties of configuration space. Furthermore, we find an unexpected relation between the number of basins accessed in equilibrium and the connectivity between them.Comment: 5 pages, 4 figure