Travelling waves in a tissue interaction model for skin pattern formation

Tissue interaction plays a major role in many morphogenetic processes, particularly those associated with skin organ primordia. We examine travelling wave solutions in a tissue interaction model for skin pattern formation which is firmly based on the known biology. From a phase space analysis we conjecture the existence of travelling waves with specific wave speeds. Subsequently, analytical approximations to the wave profiles are derived using perturbation methods. We then show numerically that such travelling wave solutions do exist and that they are in good agreement with our analytical results. Finally, the biological implications of our analysis are discussed

Is there more than one thermal source?

BRAHMS has the ability to study relativistic heavy ion collisions over a wide range of pT and rapidity. This allows us to test whether thermal models can be generalized to describe the rapidity dependence of particle ratios. This appears to work with the baryo-chemical potential changing more rapidly than the temperature. Using fits to BRAHMS data for the 5% most central Au+Au collisions we are able to describe Xi and Omega ratios from other experiments. This paper is dedicated to Julia Thompson who worked to bring South African teachers into physics.Comment: 5 pages, 4 figures, proceedings for SQM04 conference, Cape Town South Afric

Sequential pattern formation in a model for skin morphogenesis

During morphogenesis regular patterns often develop behind a frontier of pattern formation which travels across the prospective tissue. Here the authors consider the propagating patterns exhibited in a two-dimensional domain by a tissue interaction mechanochemical model for skin pattern formation. It is shown that the model can exhibit travelling waves of complex spatial pattern formation. Two alternative mechanisms that can produce such sequential patterning are presented. In particular, it is demonstrated that the specification of a simple quasi-one-dimensional pattern is all that is required to determine a complex two-dimensional pattern. Finally, the model solutions are related to actual pattern propagation during chick feather primordia initiation

Network formation of tissue cells via preferential attraction to elongated structures

Vascular and non-vascular cells often form an interconnected network in vitro, similar to the early vascular bed of warm blooded embryos. Our time-lapse recordings show that the network forms by extending sprouts, i.e., multicellular linear segments. To explain the emergence of such structures, we propose a simple model of preferential attraction to stretched cells. Numerical simulations reveal that the model evolves into a quasi-stationary pattern containing linear segments, which interconnect above the critical volume fraction of 0.2. In the quasi-stationary state the generation of new branches offset the coarsening driven by surface tension. In agreement with empirical data, the characteristic size of the resulting polygonal pattern is density-independent within a wide range of volume fractions

Age Related Changes in Cerebrovascular Reactivity and Its Relationship to Global Brain Structure

ACKNOWLEDGMENTS This study was funded by Alzheimer’s Research UK (ARUK) and the Aberdeen Biomedical Imaging Centre, University of Aberdeen. GDW, ADM and CS are part of the SINASPE collaboration (Scottish Imaging Network - A Platform for Scientific Excellence www.SINAPSE.ac.uk). The authors thank Gordon Buchan, Baljit Jagpal, Nichola Crouch, Beverly Maclennan and Katrina Klaasen for their help with running the experiment and Dawn Younie and Teresa Morris for their help with recruitment and scheduling. We also thank the residents of Aberdeen and Aberdeenshire, and further afield, for their generous participation.Peer reviewedPublisher PD

Memory-Controlled Diffusion

Memory effects require for their incorporation into random-walk models an extension of the conventional equations. The linear Fokker-Planck equation for the probability density $p(\vec r, t)$ is generalized to include non-linear and non-local spatial-temporal memory effects. The realization of the memory kernels are restricted due the conservation of the basic quantity $p$. A general criteria is given for the existence of stationary solutions. In case the memory kernel depends on $p$ polynomially the transport is prevented. Owing to the delay effects a finite amount of particles remains localized and the further transport is terminated. For diffusion with non-linear memory effects we find an exact solution in the long-time limit. Although the mean square displacement shows diffusive behavior, higher order cumulants exhibits differences to diffusion and they depend on the memory strength

Macroscopic description of particle systems with non-local density-dependent diffusivity

In this paper we study macroscopic density equations in which the diffusion coefficient depends on a weighted spatial average of the density itself. We show that large differences (not present in the local density-dependence case) appear between the density equations that are derived from different representations of the Langevin equation describing a system of interacting Brownian particles. Linear stability analysis demonstrates that under some circumstances the density equation interpreted like Ito has pattern solutions, which never appear for the Hanggi-Klimontovich interpretation, which is the other one typically appearing in the context of nonlinear diffusion processes. We also introduce a discrete-time microscopic model of particles that confirms the results obtained at the macroscopic density level.Comment: 4 pages, 3 figure

Angular Momentum Transfer in the Binary X-ray Pulsar GX 1+4

We describe three presentations relating to the X-ray pulsar GX 1+4 at a workshop on magnetic fields and accretion at the Astrophysical Theory Centre, Australian National University on 1998, November 12-13. Optical and X-ray spectroscopy indicate that GX 1+4 is seen through a cloud of gravitationaly bound matter. We discuss an unstable negative feedback mechanism (originally proposed by Kotani et al, 1999), based on X-ray heating of this matter which controls the accretion rate when the source is in a low X-ray luminosity state. A deep minimum lasting ~6 hours occurred during observations with the RXTE satellite over 1996, July 19-21. The shape of the X-ray pulses changed remarkably from before to after the minimum. These changes may be related to the transition from neutron star spin-down to spin-up which occurred at about the same time. Smoothed particle hydrodynamic simulations of the effect of adding matter with opposite angular momentum to an existing disc, show that it is possible for a number of concentric rings with alternating senses of rotation to co-exist in a disc. This could provide an explanation for the step-like changes in Pdot which are observed in GX 1+4. Changes at the inner boundary of the disc occur at the same timescale as that imposed at the outer boundary. Reversals of material torque on the neutron star occur at a minimum in L_X.Comment: 10 pages, 5 figures; accepted for publication by PAS

Truncation effects in superdiffusive front propagation with L\'evy flights

A numerical and analytical study of the role of exponentially truncated L\'evy flights in the superdiffusive propagation of fronts in reaction-diffusion systems is presented. The study is based on a variation of the Fisher-Kolmogorov equation where the diffusion operator is replaced by a $\lambda$-truncated fractional derivative of order $\alpha$ where $1/\lambda$ is the characteristic truncation length scale. For $\lambda=0$ there is no truncation and fronts exhibit exponential acceleration and algebraic decaying tails. It is shown that for $\lambda \neq 0$ this phenomenology prevails in the intermediate asymptotic regime $(\chi t)^{1/\alpha} \ll x \ll 1/\lambda$ where $\chi$ is the diffusion constant. Outside the intermediate asymptotic regime, i.e. for $x > 1/\lambda$, the tail of the front exhibits the tempered decay $\phi \sim e^{-\lambda x}/x^{(1+\alpha)}$, the acceleration is transient, and the front velocity, $v_L$, approaches the terminal speed $v_* = (\gamma - \lambda^\alpha \chi)/\lambda$ as $t\to \infty$, where it is assumed that $\gamma > \lambda^\alpha \chi$ with $\gamma$ denoting the growth rate of the reaction kinetics. However, the convergence of this process is algebraic, $v_L \sim v_* - \alpha /(\lambda t)$, which is very slow compared to the exponential convergence observed in the diffusive (Gaussian) case. An over-truncated regime in which the characteristic truncation length scale is shorter than the length scale of the decay of the initial condition, $1/\nu$, is also identified. In this extreme regime, fronts exhibit exponential tails, $\phi \sim e^{-\nu x}$, and move at the constant velocity, $v=(\gamma - \lambda^\alpha \chi)/\nu$.Comment: Accepted for publication in Phys. Rev. E (Feb. 2009

Kaon Photoproduction and the Λ\Lambda Decay Parameter α−\alpha_-

The weak decay parameter $\alpha_-$ of the $\Lambda$ is an important quantity for the extraction of polarization observables in various experiments. Moreover, in combination with $\alpha_+$ from $\bar\Lambda$ decay it provides a measure for matter-antimatter asymmetry. The weak decay parameter also affects the decay parameters of the $\Xi$ and $\Omega$ baryons and, in general, any quantity in which the polarization of the $\Lambda$ is relevant. The recently reported value by the BESIII collaboration of $0.750(9)(4)$ is significantly larger than the previous PDG value of $0.642(13)$ that had been accepted and used for over 40 years. In this work we make an independent estimate of $\alpha_-$, using an extensive set of polarization data measured in kaon photoproduction in the baryon resonance region and constraints set by spin algebra. The obtained value is 0.721(6)(5). The result is corroborated by multiple statistical tests as well as a modern phenomenological model, showing that our new value yields the best description of the data in question. Our analysis supports the new BESIII finding that $\alpha_-$ is significantly larger than the previous PDG value. Any experimental quantity relying on the value of $\alpha_-$ should therefore be re-considered.Comment: 6 pages, 1 figure