The Student Movement Volume 107 Issue 14: Week of Prayer, Wind Symphony, and Working at WAUS: Another Week at AU

HUMANS Andrews University Social Justice Club: Sara Santana, Interviewed by: Timmy Duado Honors Thesis Project: Alexander Hess, Interviewed by: Anna Pak Meet Reagan McCain of WAUS, Interviewed by: Nora Martin ARTS & ENTERTAINMENT Currently: MrBeast, Solana Campbell IN a World of Fascination: The Thematic Musicality of the AU Wind Symphony Concert, Bella Hamann Where Do I Find God - Part III, Anonymous NEWS Getting Unrealistic with Pastor Snell, Interviewed by: Gloria Oh New Recession Cracks Egg Economics Open, Andrew Francis What\u27s Happening in Peru?, Julia Randall IDEAS Facing the End of the World: What Apocalypse Stories Teach Us About Humanity, Isabella Koh I Knew You Were Trouble: On Ticketmaster\u27s Judiciary Hearing, Nora Martin Ron\u27s Gone Wrong: The Implications of the Stop W.O.K.E. Act, Bella Hamann PULSE Rutgers University Poet and Professor to Speak for Environmental Fridays, Desmond H. Murray Sex Education in the Adventist System, Zothile Sibanda Week of Prayer: Get Unrealistic, Amelia Stefanescu LAST WORD Knock Knock, Gio Leehttps://digitalcommons.andrews.edu/sm-107/1013/thumbnail.jp

Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review

Many organophosphorus (OP) based compounds are highly toxic and powerful inhibitors of cholinesterases that generate serious environmental and human health concerns. Organothiophosphates with a thiophosphoryl (P=S) functional group constitute a broad class of these widely used pesticides. They are related to the more reactive phosphoryl (P=O) organophosphates, which include very lethal nerve agents and chemical warfare agents, such as, VX, Soman and Sarin. Unfortunately, widespread and frequent commercial use of OP-based compounds in agricultural lands has resulted in their presence as residues in crops, livestock, and poultry products and also led to their migration into aquifers. Thus, the design of new sensors with improved analyte selectivity and sensitivity is of paramount importance in this area. Herein, we review recent advances in the development of fluorescent chemosensors for toxic OP pesticides and related compounds. We also discuss challenges and progress towards the design of future chemosensors with dual modes for signal transduction. © 2010 by the authors; licensee MPDI, Basel, Switzerland

Patient-Specific Prosthetic Fingers by Remote Collaboration - A Case Study

The concealment of amputation through prosthesis usage can shield an amputee from social stigma and help improve the emotional healing process especially at the early stages of hand or finger loss. However, the traditional techniques in prosthesis fabrication defy this as the patients need numerous visits to the clinics for measurements, fitting and follow-ups. This paper presents a method for constructing a prosthetic finger through online collaboration with the designer. The main input from the amputee comes from the Computer Tomography (CT) data in the region of the affected and the non-affected fingers. These data are sent over the internet and the prosthesis is constructed using visualization, computer-aided design and manufacturing tools. The finished product is then shipped to the patient. A case study with a single patient having an amputated ring finger at the proximal interphalangeal joint shows that the proposed method has a potential to address the patient's psychosocial concerns and minimize the exposure of the finger loss to the public.Comment: Open Access articl

The Student Movement Volume 107 Issue 3: Running Home: Andrews Alumni Return to Campus

HUMANS Meet Meryen Gonzalez, AUSA Religious VP, Interviewed by: Caryn Cruz Seasons of Change: Alumni Weekend 2022, Grace No Summer Mission Trip Interview with Nick Bishop, Interviewed by: Gloria Oh ARTS & ENTERTAINMENT Alumni Homecoming Gala, Wambui Karanja Currently..., Solana Campbell Hispanic Heritage Month : Highlighting the Beauty of Hispanic Crativity, Amelia Stefanescu Get Up and Go to Iceland, Jonathon Woolford-Hunt NEWS Alumni Take a Win at Saturday Night Game, Alannah Tjhatra Bradley Harvest Run Interview with Andrews Students, Interviewed by: Gloria Oh Hispanic Heritage Month-Mosaico: Colorism and Racism, Taznir Smalling, with additions by Terika Williams IDEAS Ezra Miller and The Flash , Marcel Mattox Greyhound Therapy and Forced Relocation, Valerie Akinyi The New Era of Standardized Testing, Abby Shim PULSE Andrews Celebrates the Opening of New Career Center, Reagan McCain Hispanic Heritage Month: How to Celebrate, Melissa Moore Tips for Relaxing on Campus, Wambui Karanja What Comes First is a Question, Part I, Desmond H. Murray LAST WORD Marvel\u27s Storytelling: Why We Need to Ask for Better, Alannah Tjhatrahttps://digitalcommons.andrews.edu/sm-107/1002/thumbnail.jp

The Student Movement Volume 107 Issue 12: Revisiting The Dream : Students Celebrate MLK Day

HUMANS Andrews Gaming Club, Interviewed by: Grace No Meet Gio Lee, Interviewed by: Nora Martin New Year, Happier Me, Gloria Oh ARTS & ENTERTAINMENT Art @ AU: Harrigan\u27s Gallery, Ysabelle Fernando Currently: The Way of Water, Solana Campbell Ode to 2022, Amelia Stefanescu Where Do I Find God - Part I, Anonymous NEWS Honoring Martin Luther King Jr.\u27s Legacy, Brendan Oh Is America Safe?: First Grader Shoots Teacher, Julia Randall A House Divided: Current Issues Within the School of Architecture and Interior Design, Student Movement Editorial Staff IDEAS Harry & Meghan: Unpacking Royal Pains, Gabriela Francisco A New Space for Creativity and Reaching Across Disciplinary Boundaries: The Inspiration Center, Peter Lyons, Anthony Bosman, Martin Hanna, Ryan Hayes, and Karin Thompson PULSE Our Food: Can They Cook It?, Melissa Moore Should We Have Bible Classes in the Core Curriculum?, Wambui Karanja What Comes First is a Question, Part II, Desmond H. Murray LAST WORD College in the Rearview Mirror, Scott Moncrieffhttps://digitalcommons.andrews.edu/sm-107/1011/thumbnail.jp

The benefits of participatory methodologies to develop effective community dialogue in the context of a microbicide trial feasibility study in Mwanza, Tanzania

BACKGROUND: As part of a microbicide trial feasibility study among women at high-risk of HIV and sexually transmitted infections in Mwanza City, northern Tanzania we used participatory research tools to facilitate open dialogue and partnership between researchers and study participants. METHODS: A mobile community-based sexual & reproductive health service was established in ten city wards. Wards were divided into seventy-eight geographical clusters and representatives at cluster and ward level elected in a process facilitated by the projects Community Liaison Officer. A city-level Community Advisory Committee (CAC) with representatives from each ward was established. Workshops and community meetings at ward and city-level were conducted to explore project-related concerns using tools adapted from participatory learning and action techniques such as listing, scoring, ranking, chapatti diagrams and pair-wise matrices. RESULTS: Key issues identified included beliefs that blood specimens were being sold for witchcraft purposes; worries about specula not being clean; inadequacy of transport allowances; and delays in reporting laboratory test results to participants. To date, the project has responded by inviting members of the CAC to visit the laboratory to observe how blood and genital specimens are prepared; demonstrated the use of the autoclave to community representatives; raised reimbursement levels; introduced HIV rapid testing in the clinic; and streamlined laboratory reporting procedures. CONCLUSIONS: Participatory techniques were instrumental in promoting meaningful dialogue between the research team, study participants and community representatives in Mwanza, allowing researchers and community representatives to gain a shared understanding of project-related priority areas for intervention

The PHENIX Experiment at RHIC

The physics emphases of the PHENIX collaboration and the design and current status of the PHENIX detector are discussed. The plan of the collaboration for making the most effective use of the available luminosity in the first years of RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program available at http://www.rhic.bnl.gov/phenix

Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer

<p>Abstract</p> <p>Background</p> <p>Prostaglandin E₂(PGE₂) is the major product of Cyclooxygenase-2 (COX-2) in colorectal cancer (CRC). We aimed to assess PGE₂cell surface receptors (EP 1–4) to examine the mechanisms by which PGE₂regulates tumour progression.</p> <p>Methods</p> <p>Gene expression studies were performed by quantitative RT-PCR. Cell cycle was analysed by flow cytometry with cell proliferation quantified by BrdU incorporation measured by enzyme immunoassay. Immunohistochemistry was employed for expression studies on formalin fixed paraffin embedded tumour tissue.</p> <p>Results</p> <p>EP4 was the most abundant subtype of PGE₂receptor in HT-29 and HCA7 cells (which show COX-2 dependent PGE₂generation) and was consistently the most abundant transcript in human colorectal tumours (n = 8) by qRT-PCR (ANOVA, p = 0.01). G0/G1 cell cycle arrest was observed in HT-29 cells treated with SC-236 5 μM (selective COX-2 inhibitor) for 24 hours (p = 0.02), an effect abrogated by co-incubation with PGE₂(1 μM). G0/G1 arrest was also seen with a specific EP4 receptor antagonist (EP4A, L-161982) (p = 0.01). Treatment of HT-29 cells with either SC-236 or EP4A caused reduction in intracellular cAMP (ANOVA, p = 0.01). Early induction in p21^WAF1/CIP1expression (by qRT-PCR) was seen with EP4A treatment (mean fold increase 4.4, p = 0.04) while other genes remained unchanged. Similar induction in p21^WAF1/CIP1was also seen with PD153025 (1 μM), an EGFR tyrosine kinase inhibitor, suggesting EGFR transactivation by EP4 as a potential mechanism. Additive inhibition of HCA7 proliferation was observed with the combination of SC-236 and neutralising antibody to amphiregulin (AR), a soluble EGFR ligand. Concordance in COX-2 and AR localisation in human colorectal tumours was noted.</p> <p>Conclusion</p> <p>COX-2 regulates cell cycle transition via EP4 receptor and altered p21^WAF1/CIP1expression. EGFR pathways appear important. Specific targeting of the EP4 receptor or downstream targets may offer a safer alternative to COX-2 inhibition in the chemoprevention of CRC.</p

Characterisation of a Desmosterol Reductase Involved in Phytosterol Dealkylation in the Silkworm, Bombyx mori

Most species of invertebrate animals cannot synthesise sterols de novo and many that feed on plants dealkylate phytosterols (mostly C29 and C28) yielding cholesterol (C27). The final step of this dealkylation pathway involves desmosterol reductase (DHCR24)-catalysed reduction of desmosterol to cholesterol. We now report the molecular characterisation in the silkworm, Bombyx mori, of such a desmosterol reductase involved in production of cholesterol from phytosterol, rather than in de novo synthesis of cholesterol. Phylogenomic analysis of putative desmosterol reductases revealed the occurrence of various clades that allowed for the identification of a strong reductase candidate gene in Bombyx mori (BGIBMGA 005735). Following PCR-based cloning of the cDNA (1.6 kb) and its heterologous expression in Saccharomyces cerevisae, the recombinant protein catalysed reduction of desmosterol to cholesterol in an NADH- and FAD- dependent reaction