Cooperation on Competition: The Multistate Tax Commission and State Corporate Tax Uniformity

This report explores how interstate uniformity of state corporate income taxes has varied over time, the role played by the MTC, and how likely it is that uniformity will be achieved. FRC Report 11

Protostrongylid nematodes in caribou (Rangifer tarandus caribou) and moose (Alces alces) of Newfoundland

Two species of protostrongylid nematodes with dorsal-spined, first-stage larvae, are present in caribou and moose of Newfoundland. Elaphostrongyius rangiferi Mitskevich, 1958, a parasite introduced from Scandinavia, causes periodic epizootics of a severe neurological disease in caribou. Sick animals exhibiting signs of cerebrospinal elaphostrongylosis (CSE) were particularly noticeable in central Newfoundland each winter between 1981 and 1985. Those collected for examinarion were mostly male calves. The disease again became prominent in caribou on the Avalon Peninsula in the winters of 1996 and 1997; it may have spread to that isolated part of the province as recently as 1990. E. rangiferi was also found in moose but no cases of neurologic disease have been reported in this host. Parelapbostrongylus andersoni Prestwood, 1972, was found in caribou, both in central Newfoundland and on the Avalon Peninsula. Moose may also be infected. Of 1407 terrestrial gastropod intermediate hosts examined, 9 (0.6%) contained infective, third-stage, protostrongylid larvae resembling those of E. rangiferi and P. andersoni which are indistinguishable. The small dark slug, Deroceras laeve, dominated gastropod collections and was the only species infected

Comparative Effectiveness of Step-up Therapies in Children with Asthma Prescribed Inhaled Corticosteroids : A Historical Cohort Study

This work was supported by the Respiratory Effectiveness Group. Acknowledgments We thank the Respiratory Effectiveness Group for funding this work, Annie Burden for assistance with statistics, and Simon Van Rysewyk and Lisa Law for assistance with medical writing.Peer reviewedPostprin

Inferring the eccentricity distribution

Standard maximum-likelihood estimators for binary-star and exoplanet eccentricities are biased high, in the sense that the estimated eccentricity tends to be larger than the true eccentricity. As with most non-trivial observables, a simple histogram of estimated eccentricities is not a good estimate of the true eccentricity distribution. Here we develop and test a hierarchical probabilistic method for performing the relevant meta-analysis, that is, inferring the true eccentricity distribution, taking as input the likelihood functions for the individual-star eccentricities, or samplings of the posterior probability distributions for the eccentricities (under a given, uninformative prior). The method is a simple implementation of a hierarchical Bayesian model; it can also be seen as a kind of heteroscedastic deconvolution. It can be applied to any quantity measured with finite precision--other orbital parameters, or indeed any astronomical measurements of any kind, including magnitudes, parallaxes, or photometric redshifts--so long as the measurements have been communicated as a likelihood function or a posterior sampling.Comment: Ap

Spontaneous γH2AX Foci in Human Solid Tumor-Derived Cell Lines in Relation to p21WAF1 and WIP1 Expression.

Phosphorylation of H2AX on Ser139 (γH2AX) after exposure to ionizing radiation produces nuclear foci that are detectable by immunofluorescence microscopy. These so-called γH2AX foci have been adopted as quantitative markers for DNA double-strand breaks. High numbers of spontaneous γH2AX foci have also been reported for some human solid tumor-derived cell lines, but the molecular mechanism(s) for this response remains elusive. Here we show that cancer cells (e.g., HCT116; MCF7) that constitutively express detectable levels of p21WAF1 (p21) exhibit low numbers of γH2AX foci (<3/nucleus), whereas p21 knockout cells (HCT116p21-/-) and constitutively low p21-expressing cells (e.g., MDA-MB-231) exhibit high numbers of foci (e.g., >50/nucleus), and that these foci are not associated with apoptosis. The majority (>95%) of cells within HCT116p21-/- and MDA-MB-231 cultures contain high levels of phosphorylated p53, which is localized in the nucleus. We further show an inverse relationship between γH2AX foci and nuclear accumulation of WIP1, an oncogenic phosphatase. Our studies suggest that: (i) p21 deficiency might provide a selective pressure for the emergence of apoptosis-resistant progeny exhibiting genomic instability, manifested as spontaneous γH2AX foci coupled with phosphorylation and nuclear accumulation of p53; and (ii) p21 might contribute to positive regulation of WIP1, resulting in dephosphorylation of γH2AX

Linear models for control of cavity flow oscillations

Models for understanding and controlling oscillations in the flow past a rectangular cavity are developed. These models may be used to guide control designs, to understand performance limits of feedback, and to interpret experimental results. Traditionally, cavity oscillations are assumed to be self-sustained: no external disturbances are necessary to maintain the oscillations, and amplitudes are limited by nonlinearities. We present experimental data which suggests that in some regimes, the oscillations may not be self-sustained, but lightly damped: oscillations are sustained by external forcing, such as boundary-layer turbulence. In these regimes, linear models suffice to describe the behaviour, and the final amplitude of oscillations depends on the characteristics of the external disturbances. These linear models are particularly appropriate for describing cavities in which feedback has been used for noise suppression, as the oscillations are small and nonlinearities are less likely to be important. It is shown that increasing the gain too much in such feedback control experiments can lead to a peak-splitting phenomenon, which is explained by the linear models. Fundamental performance limits indicate that peak splitting is likely to occur for narrow-bandwidth actuators and controllers

Direct constraints on the dark matter self-interaction cross-section from the merging galaxy cluster 1E0657-56

We compare new maps of the hot gas, dark matter, and galaxies for 1E0657-56, a cluster with a rare, high-velocity merger occurring nearly in the plane of the sky. The X-ray observations reveal a bullet-like gas subcluster just exiting the collision site. A prominent bow shock gives an estimate of the subcluster velocity, 4500 km/s, which lies mostly in the plane of the sky. The optical image shows that the gas lags behind the subcluster galaxies. The weak-lensing mass map reveals a dark matter clump lying ahead of the collisional gas bullet, but coincident with the effectively collisionless galaxies. From these observations, one can directly estimate the cross-section of the dark matter self-interaction. That the dark matter is not fluid-like is seen directly in the X-ray -- lensing mass overlay; more quantitative limits can be derived from three simple independent arguments. The most sensitive constraint, sigma/m<1 cm^2/g, comes from the consistency of the subcluster mass-to-light ratio with the main cluster (and universal) value, which rules out a significant mass loss due to dark matter particle collisions. This limit excludes most of the 0.5-5 cm^2/g interval proposed to explain the flat mass profiles in galaxies. Our result is only an order-of-magnitude estimate which involves a number of simplifying, but always conservative, assumptions; stronger constraints may be derived using hydrodynamic simulations of this cluster.Comment: Text clarified; some numbers changed slightly for consistency with final version of the accompanying lensing paper. 6 pages, uses emulateapj. ApJ in pres

InfiniTAM v3: A Framework for Large-Scale 3D Reconstruction with Loop Closure

Volumetric models have become a popular representation for 3D scenes in recent years. One breakthrough leading to their popularity was KinectFusion, which focuses on 3D reconstruction using RGB-D sensors. However, monocular SLAM has since also been tackled with very similar approaches. Representing the reconstruction volumetrically as a TSDF leads to most of the simplicity and efficiency that can be achieved with GPU implementations of these systems. However, this representation is memory-intensive and limits applicability to small-scale reconstructions. Several avenues have been explored to overcome this. With the aim of summarizing them and providing for a fast, flexible 3D reconstruction pipeline, we propose a new, unifying framework called InfiniTAM. The idea is that steps like camera tracking, scene representation and integration of new data can easily be replaced and adapted to the user's needs. This report describes the technical implementation details of InfiniTAM v3, the third version of our InfiniTAM system. We have added various new features, as well as making numerous enhancements to the low-level code that significantly improve our camera tracking performance. The new features that we expect to be of most interest are (i) a robust camera tracking module; (ii) an implementation of Glocker et al.'s keyframe-based random ferns camera relocaliser; (iii) a novel approach to globally-consistent TSDF-based reconstruction, based on dividing the scene into rigid submaps and optimising the relative poses between them; and (iv) an implementation of Keller et al.'s surfel-based reconstruction approach.Comment: This article largely supersedes arxiv:1410.0925 (it describes version 3 of the InfiniTAM framework