Keys to Unlock the Interlocks: Dealing with Interlocking Directorates

The use of interlocking directorates by American industrial and commercial corporations is widespread. Section 8 of the Clayton Act has been interpreted as prohibiting only interlocks between directly competing firms. There are other kinds of interlocks with substantial anticompetitive effects, however, that have essentially escaped any regulation under the antitrust laws. This article will examine whether the deleterious effects of unregulated interlocks should be a source of concern. It will conclude that these interlocks should not remain unregulated because they are presumptively anticompetitive, produce problems that section 8 was designed to address, and conflict with the basic goals of the antitrust laws. The article will then discuss presently available methods of reaching these interlocks, particularly the Justice Department\u27s attempts to read section 8 more broadly than it has traditionally been read and the Federal Trade Commission\u27s efforts to challenge interlocks through section 5 of the Federal Trade Commission Act. In addition, the article will examine proposed legislation that takes a stricter approach toward interlocks

Cure monitoring of a UV cured epoxy resin using a long period grating Mach- Zehnder interferometer

A cascaded long period grating Mach-Zehnder interferometer is used to monitor the change in refractive index of a UV cured epoxy resin over a cure cycle. Fourier techniques are used to calculate the phase shift and frequency spectral amplitude of the associated fringe pattern during the cure. The results are compared with the refractive index change during cure calculated using a Fresnel reflection based technique

Mitochondria as a therapeutic target for common pathologies.

Although the development of mitochondrial therapies has largely focused on diseases caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial proteins, it has been found that mitochondrial dysfunction also contributes to the pathology of many common disorders, including neurodegeneration, metabolic disease, heart failure, ischaemia-reperfusion injury and protozoal infections. Mitochondria therefore represent an important drug target for these highly prevalent diseases. Several strategies aimed at therapeutically restoring mitochondrial function are emerging, and a small number of agents have entered clinical trials. This Review discusses the opportunities and challenges faced for the further development of mitochondrial pharmacology for common pathologies

Using the Forest to See the Trees: Exploiting Context for Visual Object Detection and Localization

Recognizing objects in images is an active area of research in computer vision. In the last two decades, there has been much progress and there are already object recognition systems operating in commercial products. However, most of the algorithms for detecting objects perform an exhaustive search across all locations and scales in the image comparing local image regions with an object model. That approach ignores the semantic structure of scenes and tries to solve the recognition problem by brute force. In the real world, objects tend to covary with other objects, providing a rich collection of contextual associations. These contextual associations can be used to reduce the search space by looking only in places in which the object is expected to be; this also increases performance, by rejecting patterns that look like the target but appear in unlikely places. Most modeling attempts so far have defined the context of an object in terms of other previously recognized objects. The drawback of this approach is that inferring the context becomes as difficult as detecting each object. An alternative view of context relies on using the entire scene information holistically. This approach is algorithmically attractive since it dispenses with the need for a prior step of individual object recognition. In this paper, we use a probabilistic framework for encoding the relationships between context and object properties and we show how an integrated system provides improved performance. We view this as a significant step toward general purpose machine vision systems.United States. National Geospatial-Intelligence Agency (NEGI-1582-04-0004)United States. Army Research Office. Multidisciplinary University Research Initiative (Grant Number N00014-06-1-0734)National Science Foundation (U.S.). (Contract IIS-0413232)National Defense Science and Engineering Graduate Fellowshi

Designing Interprofessional Education Curriculum Using Multiple Conceptual Frameworks

With the full implementation of the Affordable Care Act and the impending physician and nursing shortage, health professional students will increasingly find themselves working together in teams to care for patients. Education at the undergraduate level is necessary for students to perform effectively in teams as practicing clinicians. We describe our approach to designing curriculum for health professional students, namely using educational conceptual frameworks such as Kotter’s 8-step Change Model, Kern’s 6-step approach to designing curriculum, and Miller’s pyramid. This approach is adaptable and transferable to other health professional schools to aid in interprofessional curriculum development

Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization

A new cyclic nitrone spin trap, [4-(3′,3′-dibutyl-2′-oxy-3′H-isoindol-5′-yloxy)butyl]triphenylphosphonium bromide (MitoSpin), bearing a lipophilic cation has been prepared by a route that involves a novel Parham-type lithiation–cyclization of an isocyanate to give the isoindolinone core. MitoSpin accumulates in a membrane potential dependent way in energized mitochondria and its oxidation could potentially be used in the study of oxidative stress resulting from reactive oxygen species generated in mitochondria

Solutions for certain classes of Riccati differential equation

We derive some analytic closed-form solutions for a class of Riccati equation y'(x)-\lambda_0(x)y(x)\pm y^2(x)=\pm s_0(x), where \lambda_0(x), s_0(x) are C^{\infty}-functions. We show that if \delta_n=\lambda_n s_{n-1}-\lambda_{n-1}s_n=0, where \lambda_{n}= \lambda_{n-1}^\prime+s_{n-1}+\lambda_0\lambda_{n-1} and s_{n}=s_{n-1}^\prime+s_0\lambda_{k-1}, n=1,2,..., then The Riccati equation has a solution given by y(x)=\mp s_{n-1}(x)/\lambda_{n-1}(x). Extension to the generalized Riccati equation y'(x)+P(x)y(x)+Q(x)y^2(x)=R(x) is also investigated.Comment: 10 page

Reactive oxygen species induce virus-independent MAVS-oligomerization in systemic lupus erythematosus

The increased expression of genes induced by type I interferon (IFN) is characteristic of viral infections and systemic lupus erythematosus (SLE). We showed that mitochondrial antiviral signaling (MAVS) protein, which normally forms a complex with retinoic acid gene I (RIG-I)–like helicases during viral infection, was activated by oxidative stress independently of RIG-I helicases. We found that chemically generated oxidative stress stimulated the formation of MAVS oligomers, which led to mitochondrial hyperpolarization and decreased adenosine triphosphate production and spare respiratory capacity, responses that were not observed in similarly treated cells lacking MAVS. Peripheral blood lymphocytes of SLE patients also showed spontaneous MAVS oligomerization that correlated with the increased secretion of type I IFN and mitochondrial oxidative stress. Furthermore, inhibition of mitochondrial reactive oxygen species (ROS) by the mitochondria-targeted antioxidant MitoQ prevented MAVS oligomerization and type I IFN production. ROS-dependent MAVS oligomerization and type I IFN production were reduced in cells expressing the MAVS-C79F variant, which occurs in 30% of sub-Saharan Africans and is linked with reduced type I IFN secretion and milder disease in SLE patients. Patients expressing the MAVS-C79F variant also had reduced amounts of oligomerized MAVS in their plasma compared to healthy controls. Together, our findings suggest that oxidative stress–induced MAVS oligomerization in SLE patients may contribute to the type I IFN signature that is characteristic of this syndrome

The Grizzly, September 2, 1988

Olin Foundation Grants 5.37 Million Gift • Richter Answers Pleas to Please • OSL Pounds Alcohol Policy • Akin and Pilgrim Promoted • Ursinus College Welcome the Fabulous Fourteen • Hemphill \u27Happening\u27 in History • UC Sports Celebrates Centennial Season • Football Captains Named • X-Country Running in High Gear • Highlighting Two Fantastic Freshmenhttps://digitalcommons.ursinus.edu/grizzlynews/1215/thumbnail.jp