Book Review: History of the Supreme Court of the United States, Volume Ix: The Judiciary and Responsible Government 1910-1921. by Alexander M. Bickel and Benno C. Schmidt, Jr.

Book review: History of the Supreme Court of the United States, Volume IX: The Judiciary and Responsible Government 1910-1921. By Alexander M. Bickel and Benno C. Schmidt, Jr. New York: Macmillan. 1984. Pp. xiv, 1041. Reviewed by: Paul L. Murphy

Constitutional Scholarship: What Next?

Part of Symposium "Constitutional Scholarship: What Next?

Book Review: Justice at War. by Peter Irons.

Book review: Justice At War. By Peter Irons.\u27 New York: Oxford University Press. 1983. Pp. xiii, 407. Reviewed by Paul L. Murph

Book Review: History of the Supreme Court of the United States, Volume Ix: The Judiciary and Responsible Government 1910-1921. by Alexander M. Bickel and Benno C. Schmidt, Jr.

Book review: History of the Supreme Court of the United States, Volume IX: The Judiciary and Responsible Government 1910-1921. By Alexander M. Bickel and Benno C. Schmidt, Jr. New York: Macmillan. 1984. Pp. xiv, 1041. Reviewed by: Paul L. Murphy

Book Review: Justice at War. by Peter Irons.

Book review: Justice At War. By Peter Irons.\u27 New York: Oxford University Press. 1983. Pp. xiii, 407. Reviewed by Paul L. Murph

β-Secretases, Alzheimer\u27s Disease, and Down Syndrome

Individuals with Down Syndrome (DS), or trisomy 21, develop Alzheimer\u27s disease (AD) pathology by approximately 40 years of age. Chromosome 21 harbors several genes implicated in AD, including the amyloid precursor protein and one homologue of the β-site APP cleaving enzyme, BACE2. Processing of the amyloid precursor protein by β-secretase (BACE) is the rate-limiting step in the production of the pathogenic Aβ peptide. Increased amounts of APP in the DS brain result in increased amounts of Aβ and extracellular plaque formation beginning early in life. BACE dysregulation potentially represents an overlapping biological mechanism with sporadic AD and a common therapeutic target. As the lifespan for those with DS continues to increase, age-related concerns such as obesity, depression, and AD are of growing concern. The ability to prevent or delay the progression of neurodegenerative diseases will promote healthy aging and improve quality of life for those with DS

β-Secretases, Alzheimer's Disease, and Down Syndrome

Individuals with Down Syndrome (DS), or trisomy 21, develop Alzheimer's disease (AD) pathology by approximately 40 years of age. Chromosome 21 harbors several genes implicated in AD, including the amyloid precursor protein and one homologue of the β-site APP cleaving enzyme, BACE2. Processing of the amyloid precursor protein by β-secretase (BACE) is the rate-limiting step in the production of the pathogenic Aβ peptide. Increased amounts of APP in the DS brain result in increased amounts of Aβ and extracellular plaque formation beginning early in life. BACE dysregulation potentially represents an overlapping biological mechanism with sporadic AD and a common therapeutic target. As the lifespan for those with DS continues to increase, age-related concerns such as obesity, depression, and AD are of growing concern. The ability to prevent or delay the progression of neurodegenerative diseases will promote healthy aging and improve quality of life for those with DS