A Case of Generalized Acanthosis Nigricans with Positive Lupus Erythematosus-Related Autoantibodies and Antimicrosomal Antibody: Autoimmune Acanthosis Nigricans?

Acanthosis nigricans (AN) is a hyperpigmented keratotic skin lesion known to be associated with malignant disease and endocrinopathy. We report a very rare case of generalized AN with Sjögren's syndrome- and systemic lupus erythematosus-like features but without type B insulin resistance. Neither internal malignancy nor other endocrinological disorders, including glucose intolerance, were detected during a 10-year clinical course with benign diffuse papillomatosis extending from the mucosa of the larynx to the esophagogastric junction. The case was complicated with chronic thyroiditis and interstitial pneumonia, which were not treated with any medication. AN skin lesions and mucosal papillomatosis regressed with oral cyclosporine A, accompanied by the lowering of autoantibody titers. This is the first report of generalized AN involving an area from the mucosa of the larynx to the esophagogastric junction accompanied by autoimmune manifestations which responded to systemic immunosuppressive therapy

Discrete Convex Functions on Graphs and Their Algorithmic Applications

The present article is an exposition of a theory of discrete convex functions on certain graph structures, developed by the author in recent years. This theory is a spin-off of discrete convex analysis by Murota, and is motivated by combinatorial dualities in multiflow problems and the complexity classification of facility location problems on graphs. We outline the theory and algorithmic applications in combinatorial optimization problems

Solving the Bethe-Salpeter Equation for Scalar Theories in Minkowski Space

The Bethe-Salpeter (BS) equation for scalar-scalar bound states in scalar theories without derivative coupling is formulated and solved in Minkowski space. This is achieved using the perturbation theory integral representation (PTIR), which allows these amplitudes to be expressed as integrals over weight functions and known singularity structures and hence allows us to convert the BS equation into an integral equation involving weight functions. We obtain numerical solutions using this formalism for a number of scattering kernels to illustrate the generality of the approach. It applies even when the na\"{\i}ve Wick rotation is invalid. As a check we verify, for example, that this method applied to the special case of the massive ladder exchange kernel reproduces the same results as are obtained by Wick rotation.Comment: 23 pages with 3 uuencoded, compressed Postscript figures. Entire manuscript available as a ps file at http://www.physics.adelaide.edu.au/theory/home.html . Also available at ftp://adelphi.adelaide.edu.au/pub/theory/ADP-94-24.T164.p

Do Prices Coordinate Markets?

Walrasian equilibrium prices can be said to coordinate markets: They support a welfare optimal allocation in which each buyer is buying bundle of goods that is individually most preferred. However, this clean story has two caveats. First, the prices alone are not sufficient to coordinate the market, and buyers may need to select among their most preferred bundles in a coordinated way to find a feasible allocation. Second, we don't in practice expect to encounter exact equilibrium prices tailored to the market, but instead only approximate prices, somehow encoding "distributional" information about the market. How well do prices work to coordinate markets when tie-breaking is not coordinated, and they encode only distributional information? We answer this question. First, we provide a genericity condition such that for buyers with Matroid Based Valuations, overdemand with respect to equilibrium prices is at most 1, independent of the supply of goods, even when tie-breaking is done in an uncoordinated fashion. Second, we provide learning-theoretic results that show that such prices are robust to changing the buyers in the market, so long as all buyers are sampled from the same (unknown) distribution

Perturbation theory of bound states and resonances where potentials and propagators have arbitrary energy dependence

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Sutherlandia frutescens: The meeting of science and traditional knowledge

Sutherlandia frutescens (L.) R.Br. (syn. Lessertia frutescens (L.) Goldblatt and J.C. Manning) is an indigenous medicinal plant extensively used in South Africa to treat a variety of health conditions. It is a fairly widespread, drought-resistant plant that grows in the Western, Eastern, and Northern Cape provinces and some areas of KwaZulu-Natal, varying in its chemical and genetic makeup across these geographic areas.1 Sutherlandia is widely used as a traditional medicine. Extensive scientific studies are being carried out on the safety, quality, and the efficacy of this medicinal plant to validate the traditional claims, elucidate the bioactive constituents, and conduct clinical trials. This has resulted in a unique situation in South Africa’s history, where traditional knowledge and science intersect to provide insight into this popular plant. This photoessay attempts to illustrate the interlinkage of science with the indigenous knowledge of traditional healers, the local knowledge of people who care for the sick, product development, and innovation agenda of the country as it relates to this plant.Web of Scienc

First detection of a Vssc allele V1016G conferring a high level of insecticide resistance in Aedes albopictus collected from Europe (Italy) and Asia (Vietnam), 2016. A new emerging threat to controlling arboviral diseases

Introduction Aedes albopictus (Skuse) is an important vector of arboviral diseases, including dengue, chikungunya and Zika virus disease. Monitoring insecticide resistance and mechanisms by which the mosquito develops resistance is crucial to minimise disease transmission. Aim To determine insecticide resistance status and mechanisms in Ae. albopictus from different geographical regions. Methods We sampled 33 populations of Ae. albopictus from Asia, Europe and South America, and tested these for susceptibility to permethrin, a pyrethroid insecticide. In resistant populations, the target site for pyrethroids, a voltage-sensitive sodium channel (Vssc) was genotyped. Three resistant sub-strains, each harbouring a resistance allele homozygously, were established and susceptibilities to three different pyrethroids (with and without a cytochrome P450 inhibitor) were assayed. Results Most populations of Ae. albopictus tested were highly susceptible to permethrin but a few from Italy and Vietnam (4/33), exhibited high-level resistance. Genotyping studies detected a knockdown resistance (kdr) allele V1016G in Vssc for the first time in Ae. albopictus. Two previously reported kdr alleles, F1534C and F1534S, were also detected. The bioassays indicated that the strain homozygous for the V1016G allele showed much greater levels of pyrethroid resistance than other strains harbouring F1534C or F1534S. Conclusion The V1016G allele was detected in bothAsian and Italian Ae. albopictus populations, thus a spread of this allele beyond Italy in Europe cannot be ruled out. This study emphasises the necessity to frequently and regularly monitor the V1016G allele in Ae. albopictus, particularly where this mosquito species is the main vector of arboviruses

Determination of V_cb from exclusive decays in a relativistic quark model

In the framework of a relativistic covariant Bethe-Salpeter model for the quark-antiquark system we present a renewed determination of the Cabbibo-Kobayashi-Maskawa matrix element $|V_{cb}|$. Complementing an earlier analysis applied to the whole decay spectrum for $B\to D^* e\nu$ we now also employ the ``zero-recoil method'' that uses the end point of the decay spectrum ($\omega=1$) and is suited for heavy-to-heavy transitions. The averaged experimental value extracted from the data at zero recoil, $|V_{cb}|{\cal F}(\omega=1)=0.0343\pm0.0015$, then leads to $|V_{cb}|=0.0360\pm 0.0016$. This value is somewhat larger than the one that uses the whole decay spectrum for the model analysis. We also contrast this result to a nonrelativistic model and to recent experiments on the $B\to D e\nu$ semileptonic decay.Comment: 7 pages, 4 figures, RevTe

Staffing decisions for heterogeneous workers with turnover

In this paper we consider a firm that employs heterogeneous workers to meet demand for its product or service. Workers differ in their skills, speed, and/or quality, and they randomly leave, or turn over. Each period the firm must decide how many workers of each type to hire or fire in order to meet randomly changing demand forecasts at minimal expense. When the number of workers of each type can by continuously varied, the operational cost is jointly convex in the number of workers of each type, hiring and firing costs are linear, and a random fraction of workers of each type leave in each period, the optimal policy has a simple hire- up-to/fire-down-to structure. However, under the more realistic assumption that the number of workers of each type is discrete, the optimal policy is much more difficult to characterize, and depends on the particular notion of discrete convexity used for the cost function. We explore several different notions of discrete convexity and their impact on structural results for the optimal policy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45844/1/186_2005_Article_33.pd

Reduction of anxiety-like and depression-like behaviors in rats after one month of drinking Aronia melanocarpa berry juice

The treatment of mood and anxiety disorders by nutraceuticals is gaining growing awareness. Berries of Aronia melanocarpa (Black chokeberry) and their extracts, exceptionally abundant in diverse phenolic compounds, have become famous for the highest in vitro antioxidant activity among fruits and notable health benefits (e.g. anti-diabetic, anti-inflammatory, cardioprotective). This study was designed to investigate the behavioral effects of month-long unlimited consumption of Aronia master juice (AJ) and/or juice reconstruct without polyphenols (RJ), in young male rats. AJ was initially evaluated for its content of phenolic compounds by spectrophotometric assays and HPLC-DAD. Rats that were supplied with three various water concentrations of AJ and RJ, respectively: 20% + 0% (ARO group), 5% + 15% (RAJ) and 0 + 20% (PLC), were compared with those which consumed only water (CTL). Daily drinking of AJ solution was significantly elevated from the second or third week onward, which was most expressed in the ARO group. Only this group displayed behavioral variations, manifested by certain hyperactivity in open field tests and prominent reductions of anxiety-like behaviors in the elevated plus maze. The ARO rats also expressed an alleviation of depression-like behavior in forced swimming tests. These findings demonstrate the beneficial behavioral effects of the one-month-long free drinking of phenolic-rich AJ in rats ( gt 20 ml per kg b. mass daily) that may be recognized as stimulating, anxiolytic-like and antidepressant-like. The in vitro assays suggested that MAO-A/MAO-B inhibitions by the phenolic compounds of AJ might be the possible in vivo mechanisms for such behavioral actions