The MeerKAT Fornax Survey

We present the science case and observations plan of the MeerKAT Fornax Survey, an HI and radio continuum survey of the Fornax galaxy cluster to be carried out with the SKA precursor MeerKAT. Fornax is the second most massive cluster within 20 Mpc and the largest nearby cluster in the southern hemisphere. Its low X-ray luminosity makes it representative of the environment where most galaxies live and where substantial galaxy evolution takes place. Fornax's ongoing growth makes it an excellent laboratory for studying the assembly of clusters, the physics of gas accretion and stripping in galaxies falling in the cluster, and the connection between these processes and the neutral medium in the cosmic web. We will observe a region of 12 deg2 reaching a projected distance of 1.5 Mpc from the cluster centre. This will cover a wide range of environment density out to the outskirts of the cluster, where gas-rich in-falling groups are found. We will: study the HI morphology of resolved galaxies down to a column density of a few times 1e+19 cm−2 at a resolution of 1 kpc; measure the slope of the HI mass function down to M(HI) 5e+5 M(sun); and attempt to detect HI in the cosmic web reaching a column density of 1e+18 cm−2 at a resolution of 10 kpc

The MeerKAT Fornax Survey. I. Survey description and first evidence of ram pressure in the Fornax galaxy cluster

The MeerKAT Fornax Survey maps the distribution and kinematics of atomic neutral hydrogen gas (HI) in the nearby Fornax galaxy cluster using the MeerKAT telescope. The 12 deg^2 survey footprint covers the central region of the cluster out to ~ Rvir and stretches out to ~ 2 Rvir towards south west to include the NGC 1316 galaxy group. The HI column density sensitivity (3 sigma over 25 km/s) ranges from 5e+19/cm^2 at a resolution of ~ 10" (~ 1 kpc at the 20 Mpc distance of Fornax) down to ~ 1e+18/cm^2 at ~ 1' (~ 6 kpc), and slightly below this level at the lowest resolution of ~ 100" (~ 10 kpc). The HI mass sensitivity (3 sigma over 50 km/s) is 6e+5 Msun. The HI velocity resolution is 1.4 km/s. In this paper we describe the survey design and HI data processing, and we present a sample of six galaxies with long, one-sided, star-less HI tails (of which only one was previously known) radially oriented within the cluster and with measurable internal velocity gradients. We argue that the joint properties of the HI tails represent the first unambiguous evidence of ram pressure shaping the distribution of HI in the Fornax cluster. The disturbed optical morphology of all host galaxies supports the idea that the tails consist of HI initially pulled out of the galaxies' stellar body by tidal forces. Ram pressure was then able to further displace the weakly bound HI and give the tails their present direction, length and velocity gradient.Comment: Astronomy & Astrophysics, accepted. Data available at the MeerKAT Fornax Survey website https://sites.google.com/inaf.it/meerkatfornaxsurve

Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders

Postsynaptic density (PSD) proteins have been implicated in the pathophysiology of neurodevelopmental and psychiatric disorders. Here, we present detailed clinical and genetic data for 20 patients with likely gene-disrupting mutations in TANC2-whose protein product interacts with multiple PSD proteins. Pediatric patients with disruptive mutations present with autism, intellectual disability, and delayed language and motor development. In addition to a variable degree of epilepsy and facial dysmorphism, we observe a pattern of more complex psychiatric dysfunction or behavioral problems in adult probands or carrier parents. Although this observation requires replication to establish statistical significance, it also suggests that mutations in this gene are associated with a variety of neuropsychiatric disorders consistent with its postsynaptic function. We find that TANC2 is expressed broadly in the human developing brain, especially in excitatory neurons and glial cells, but shows a more restricted pattern in Drosophila glial cells where its disruption affects behavioral outcomes