Idiopathic Recurrent Stupor, Still an Unsolved Issue

We report a case of unexplained recurrent stupor for which, given the current knowledge and the lack of easily available diagnostic tools, we were unable to reach a definite diagnosis. In the patient the syndrome was associated with an ominous prognosis. Worldwide accepted and easily available proceeding method is needed to manage patients with recurrent stupor for which a toxic origin may be suppose

Restless legs syndrome and periodic limb movements after ischemic stroke in the right lenticulostriate region

We report the first instance of restless legs syndrome (RLS) associated with periodic limb movements (PLM) and disruption of sleep architecture occurring in a patient following ischemic infarction in the right lenticulostriate region. Recently, a role for the basal ganglia-brainstem system in the control of motor behaviors and in the regulation of awake-sleep states has been proposed. The purported roles of these structures may be relevant in explaining the occurrence of the RLS in our patient. The discrete brain localization observed in this patient may be a clue to a better understanding of the pathophysiology of RLS and PLM. (C) 2007 Elsevier Ltd. All rights reserved

Cerebellar tremor with anti-GAD antibodies

Glutamic acid decarboxylase (GAD) catalyzes the conversion of glutamic acid to gamma-aminobutyric acid (GABA). Autoantibodies directed against GAD (anti-GAD-Ab) have been described in a few patients with progressive cerebellar ataxia, however, the occurrence of a definite cerebellar tremor has not been documented